Bcr-Abl

Catalog No.Inhibitor Name Bcr-AblAblOther
A10290Dasatinib
****
****
Src,c-Kit (D816V),c-Kit (wt)
A10468Imatinib Mesylate
*
c-Kit,PDGFR
A10108Saracatinib
**
c-Src,LCK,EGFR (L861Q)
A10080Ponatinib
****
****
PDGFRα,VEGFR2,FGFR1
A10644Nilotinib
**
A10715Danusertib
**
**
Aurora A,TrkA,RET
A10095AT9283
***
JAK3,JAK2,Aurora B
A10988Degrasyn
*
DUB
A10119Bafetinib
***
***
Lyn
A10508KW-2449
**
***
FLT3 (D835Y),FLT3,FGFR1
A10661NVP-BHG712
*
EphB4,C-Raf,c-Src
A11200Rebastinib
***
FLT3,KDR,Tie-2
A15849GZD824 Dimesylate
****
****
A11439GNF-2
*
A15887GNF-7
***
*
A13029Radotinib
**
A16320Dasatinib Monohydrate
****
****
Src,c-Kit (D816V),c-Kit (wt)
A13237GNF-5
*
A13120PD173955
***
Src
A11379DPH
A13530Flumatinib mesylate
****
PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GZD824 Dimesylate

    Catalog No. A15849
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    Bcr-Abl Inhibitor
    GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. Learn More
  2. Saracatinib (AZD0530)

    Catalog No. A10108
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    Src/Abl inhibitor
    Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Learn More
  3. ON 146040

    Catalog No. A16266
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    dual PI3K and BCR-ABL inhibitor
    ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM. Learn More
  4. Lyn-IN-1

    Catalog No. A16265
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    dual Bcr-Abl/Lyn inhibitor
    Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor, extracted from patent WO2014169128A1. Learn More
  5. Flumatinib mesylate

    Catalog No. A13530
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    c-Abl/c-Kit/PDGRFβ inhibitor
    Flumatinib mesylate can reduce the expression of C-MYC, HIF-1 a and VEGF in U266 cell line in a time- and dose-dependent manners, so flumatinib mesylate may become a new drug for MM therapy. Learn More
  6. GNF-7

    Catalog No. A15887
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    Bcr-Abl inhibitor
    GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively. Learn More
  7. DPH

    Catalog No. A11379
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    c-ABL activitor
    DPH is a c-ABL activitor. Learn More
  8. Dasatinib (BMS-354825)

    Catalog No. A10290
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    Abl-Src inhibitor
    Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2. Learn More
  9. Nilotinib monohydrochloride monohydrate

    Catalog No. A15186
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    Bcr-Abl inhibitor
    Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM. Learn More
  10. NRC-AN-019

    Catalog No. A13562
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    Bcr-Abl inhibitor
    NRC-AN-019 is an orally administered tyrosine kinase inhibitor (TKI) of the Bcr-Abl protein-tyrosine kinase. NRC-AN-019 is more effective in inhibiting angiogenic potential and proliferation of both MDAMB231 and HTB20/BT474 cells. Learn More
  11. AST 487

    Catalog No. A15003
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    RET kinase inhibitor
    AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret. Learn More
  12. Radotinib (IY-5511)

    Catalog No. A13029
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    Bcr-Abl tyrosine inhibitor‎
    Radotinib is a novel and selective Bcl-Abl tyrosine kinase inhibitor Learn More
  13. Imatinib (Gleevec)

    Catalog No. A10259
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    PDGFR inhibitor
    Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. Learn More
  14. Flumatinib

    Catalog No. A16258
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    multi-kinase inhibitor
    Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRbeta and c-Kit respectively. Learn More
  15. GZD824

    Catalog No. A16264
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    Bcr-Abl inhibitor
    GZD824 is a novel orally bioavailable inhibitor against a broad spectrum of Bcr-Abl mutants including T315I. Learn More
  16. GNF-5

    Catalog No. A13237
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    Bcr-Abl inhibitor
    GNF-5 is a selective allosteric inhibitor of BCR-ABL. Learn More
  17. PD173955

    Catalog No. A13120
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    Bcr-Abl inhibitor
    PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Learn More
  18. XL-228

    Catalog No. A13069
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    IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
    XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More
  19. AT9283

    Catalog No. A10095
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    Aurora/JAK inhibitor
    AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation. Learn More
  20. AP24534 (Ponatinib)

    Catalog No. A10080
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    BCR-ABL inhibitor
    AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor. Learn More
  21. WP1130 (Degrasyn)

    Catalog No. A10988
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    DUB/Bcr/ABL Inhibitor
    WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. Learn More
  22. Danusertib (PHA-739358)

    Catalog No. A10715
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    Aurora inhibitor
    Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More
  23. Bafetinib (INNO-406)

    Catalog No. A10119
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    Bcr-Abl inhibitor
    Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia. Learn More
  24. KW-2449

    Catalog No. A10508
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    FLT3/FGFR/Bcr-Abl/Aurora Inhibitor
    KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. Learn More
  25. Imatinib Mesylate

    Catalog No. A10468
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    Bcr-Abl inhibitor
    Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway. Learn More
  26. NVP-BHG712

    Catalog No. A10661
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    EphB4 inhibitor
    NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Learn More
  27. DCC-2036 (Rebastinib)

    Catalog No. A11200
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    Bcr-Abl inhibitor

    DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

    Learn More
  28. PP121

    Catalog No. A11207
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    PI3K Inhibitor
    PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More
  29. Nilotinib (AMN-107)

    Catalog No. A10644
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    Bcr-Abl inhibitor
    Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM. Learn More
  30. GNF 2

    Catalog No. A11439
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    Bcr-Abl inhibitor
    GNF 2 is a Bcr-abl inhibitor that inhibits proliferation and induces apoptosis in Bcr-abl-expressing cells. Learn More
  31. Dasatinib Monohydrate

    Catalog No. A16320
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    Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively. Learn More

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