ALK

Catalog No.Inhibitor Name ALKOther
A10712Crizotinib
*
c-Met
A10662TAE684
**
A11134Alectinib
**
INSR,KDR
A13238Ceritinib
****
Insulin Receptor,IGF-1R,STK22D
A11948AP26113
***
FER,ROS/ROS1,FLT3
A11175GSK1838705A
***
Insulin Receptor,IGF-1R,RSK1
A13065AZD3463
***
A11773ASP3026
*
A14207PF-06463922
****
LTK (TYK1),FER,FES (FPS)
A15801Entrectinib
TrkC,TrkB,TrkA
A13450Brigatinib (AP26113)
****
FLT3,IGF1R,EGFR(C797S/del19)
A13744CEP-28122
****
A15511KRCA-0008
***
Ack1
A15543CEP-37440
**
FAK
A16267HG-14-10-04
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. PF-2341066 (Crizotinib)

    Catalog No. A10712
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    ALK/ c-Met inhibitor
    PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Learn More
  2. ALK inhibitor 1

    Catalog No. A14987
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    ALK inhibitor
    ALK inhibitor 1 is a novel and selective inhibitor for the ALK kinase. Learn More
  3. ALK inhibitor 2

    Catalog No. A14988
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    ALK inhibitor
    ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase. Learn More
  4. CEP-37440

    Catalog No. A15543
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    FAK/ALK inhibitor
    CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). Learn More
  5. KRCA-0008

    Catalog No. A15511
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    ACK1/ALK inhibitor
    KRCA-0008 is a potent and selective ALK/Ack1 inhibitor with IC50 of 12 nM/4 nM for ALK and Ack1 respectively; displays drug-like properties without hERG liability. Learn More
  6. Entrectinib

    Catalog No. A15801
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    TRK, ROS1, ALK inhibitor
    Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. Learn More
  7. Brigatinib (AP26113)

    Catalog No. A13450
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    ALK Inhibitor
    Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy. Learn More
  8. LDN-214117

    Catalog No. A16096
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    ALK2 inhibitor
    LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. Learn More
  9. R-268712

    Catalog No. A16207
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    ALK5 inhibitor
    R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM. Learn More
  10. Crizotinib hydrochloride

    Catalog No. A16245
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    c-Met/NPM-ALK inhibitor
    Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Learn More
  11. HG-14-10-04

    Catalog No. A16267
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    ALK inhibitor
    HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM. Learn More
  12. WY-135

    Catalog No. A20071
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    ALK/ ROS1 dual inhibitor
    WY-135 is an ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor. Learn More
  13. Duocarmycin GA

    Catalog No. A18546
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    DNA alkylating agent
    Duocarmycin GA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-drug resistant cell lines. Learn More
  14. ALK2-IN-2

    Catalog No. A13604
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    Alk2 inhibitor
    ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3. Learn More
  15. Alectinib Hydrochloride

    Catalog No. A18000
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    ALK inhibitor
    Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Learn More
  16. Belizatinib

    Catalog No. A20919
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    ALK/TRKA/TRKB/TRKC inhibitor
    Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7?nM for wild-type recombinant ALK kinase. Learn More
  17. Ensartinib hydrochloride

    Catalog No. A21719
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    ALK/MET inhibitor
    Ensartinib hydrochloride (X-396 hydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. Learn More
  18. LDK378 (Ceritinib) dihydrochloride

    Catalog No. A15142
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    ALK inhibitor
    LDK378 dihydrochloride is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Learn More
  19. A 77-01

    Catalog No. A14436
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    ALK5 inhibitor
    A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. Learn More
  20. TAE684

    Catalog No. A10662
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    ALK Inhibitor
    TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant). Learn More
  21. SB-505124

    Catalog No. A11157
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    ALK5 inhibitor
    SB-505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Learn More
  22. GSK1838705A

    Catalog No. A11175
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    IGF-1R Inhibitor

    GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

    Learn More
  23. LDN193189

    Catalog No. A11205
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    ALK inhibitor
    LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation. Learn More
  24. SB 525334

    Catalog No. A10827
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    ALK Inhibitor
    SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells Learn More
  25. CH5424802

    Catalog No. A11134
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    ALK Inhibitor
    CH5424802 is a potent, selective, and orally available ALK inhibitor with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK. Learn More
  26. ASP3026

    Catalog No. A11773
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    ALK inhibitor
    ASP3026 is a novel and selective inhibitor for the ALK kinase. ASP3026 potently inhibited ALK kinase activity and was more selective than crizotinib in a Tyr-kinase panel. Learn More
  27. ALK-IN-1 (Brigatinib analog, AP26113 analog)

    Catalog No. A11948
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    ALK inhibitor
    AP26113 is an orally-available, potent, and selective inhibitor of ALK with a potency of 0.62 nM against wild-type and activity against a wide range of mutants, including the crizotinib-resistant L1196M line. In a panel of EML4-ALK or NPM-ALK-positive cell lines, AP26113 has IC50 values of 4-31 nM. [1][2] AP26113 is effective against sensitive and resistant H3122 cells, reducing cell growth, suppressing ALK phosphorylation, and inducing apoptosis. In Ba/F3 cells expressing native or mutant EML4-ALK, AP26113 was active at IC50s of 10 and 24 nM, respectively. [3] Learn More
  28. A 83-01

    Catalog No. A12358
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    TGF-β/ALK5 inhibitor
    A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7 Learn More
  29. WZ4003

    Catalog No. A14312
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    NUAK kinase inhibitor
    WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 Learn More
  30. PF-06463922

    Catalog No. A14207
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    ALK inhibitor
    PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. Learn More
  31. EW-7197

    Catalog No. A14213
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    ALK4/ALK5 inhibitor
    EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively Learn More
  32. CEP-28122

    Catalog No. A13744
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    ALK inhibitor
    CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Learn More
  33. AZD3463

    Catalog No. A13065
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    ALK/IGF1R inhibitor
    AZD-3463 is a ALK/IGF1R inhibitor. Learn More
  34. LDK-378

    Catalog No. A13238
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    ALK Inhibitor
    LDK378 is a highly selective, orally bioavailable and ATP-competitive small molecule inhibitor of ALK (Anaplastic Lymphoma Kinase), a receptor tyrosine kinase considered to be an important lung cancer drug target. Learn More
  35. DMH-1

    Catalog No. A12820
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    ALK2 inhibitor
    DMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Learn More
  36. X-376

    Catalog No. A20971
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    ALK inhibitor
    X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0.61 nM). X-376 is a less potent inhibitor of MET (IC50=0.69 nM). X-376 displays potent anti-tumor activity. Learn More
  37. ALK-IN-6

    Catalog No. A18457
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    ALK inhibitor
    ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively. Learn More

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