Total item
Cart Subtotal
$0.00 Topoisomerase
| Catalog No. | Inhibitor Name | Topoisomerase | Topo I | Topo II | Topo IV | Other |
|---|---|---|---|---|---|---|
| A10174 | Camptothecin | ** | ||||
| A10939 | Topotecan HCl | **** | ||||
| A10465 | Idarubicin HCl | *** | Multicellular spheroids | |||
| A10194 | Daunorubicin HCl | *** | ||||
| A11999 | Betulinic acid | ** | HIV-1,Aminopeptidase N | |||
| A11861 | Flumequine | * | ||||
| A14403 | Doxorubicin | |||||
| A10373 | Etoposide | |||||
| A10478 | Irinotecan | |||||
| A10345 | Epirubicin HCl | |||||
| A10596 | Mitoxantrone HCl | |||||
| A10609 | Moxifloxacin HCl | |||||
| A10479 | Irinotecan HCl Trihydrate | |||||
| A12011 | SN-38 | |||||
| A10071 | Amonafide | |||||
| A10907 | Teniposide | |||||
| A10419 | Gatifloxacin | |||||
| A10426 | Genistein | EGFR | ||||
| A10595 | Mitoxantrone | |||||
| A10735 | Pirarubicin | |||||
| A10041 | Adriamycin | |||||
| A10557 | Marbofloxacin | |||||
| A10666 | Ofloxacin | |||||
| A10740 | Podophyllotoxin | |||||
| A12663 | Amrubicin | |||||
| A13059 | Beta-Lapachone | IDO1 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
-
GENZ-644282
Catalog No. A13206 topoisomerase 1 inhibitorGenz-644282 is a non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Learn More -
Karenitecin
Catalog No. A21156 topoisomerase I inhibitorKarenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity. Learn More -
Namitecan
Catalog No. A21146 topoisomerase I inhibitorNamitecan is a potent topoisomerase I inhibitor, with antitumor property. Learn More -
Gepotidacin
Catalog No. A21086 topoisomerase II inhibitorGepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. Learn More -
Pirarubicin Hydrochloride
Catalog No. A18037 topoisomerase II inhibitorPirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. Learn More -
9-amino-CPT
Catalog No. A12540 Topoisomerase I inhibitor9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity. Learn More -
MAC glucuronide phenol-linked SN-38
Catalog No. A18403 DNA topoisomerase I inhibitorMAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. Learn More -
CL2A-SN-38
Catalog No. A18392 DNA Topoisomerase I inhibitorCL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. Learn More -
Epirubicin
Catalog No. A12409 Topoisomerase inhibitorEpirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin’s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II). Learn More -
Amsacrine hydrochloride
Catalog No. A17707 topoisomerase II inhibitorAmsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. Learn More -
Beta-Lapachone
Catalog No. A13059 DNA topoisomerase II inhibitorBeta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Learn More -
SN 38
Catalog No. A12011 DNA topoisomerase InhibitorSN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor). Learn More -
(-)-Epigallocatechin gallate
Catalog No. A10005 Antioxidant, antiangiogenic, antitumor agent(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea. Learn More -
Doxorubicin
Catalog No. A14403 Topoisomerase II inhibitorDoxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. Learn More -
Ellipticine
Catalog No. A13780 DNA topoisomerase II inhibitorEllipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Learn More -
NK314
Catalog No. A13993 Topoisomerase II inhibitorNK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. Learn More -
ABT 492 meglumine (Delafloxacin meglumine)
Catalog No. A15064 ABT 492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro: Learn More -
Irinotecan
Catalog No. A10478 Topoisomerase I inhibitorIrinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. Learn More -
TAS-103
Catalog No. A21954 DNA topoisomerase I/II inhibitorTAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. Learn More -
Amonafide (AS1413)
Catalog No. A10071 Topoisomerase inhibitorAmonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.
Learn More -
Daunorubicin
Catalog No. A21903 topoisomerase II inhibitorDaunorubicin (Daunomycin; RP 13057; Rubidomycin) is a topoisomerase II inhibitor with potent antineoplastic activities. Learn More -
Daun02
Catalog No. A21818 prodrug of the topoisomerase inhibitor DaunorubicinDaun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. Learn More -
Moxifloxacin HCl
Catalog No. A10609 Topoisomerase inhibitorMoxifloxacin is a quinolone/fluoroquinolone antibiotic. Learn More -
Dxd
Catalog No. A21517 DNA topoisomerase I inhibitorDxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Learn More -
Exatecan Mesylate
Catalog No. A21515 DNA topoisomerase I inhibitorExatecan Mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. Learn More -
Edotecarin
Catalog No. A21233 Topoisomerase I inhibitorEdotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM. Learn More -
Etoposide (VP-16)
Catalog No. A10373 Topoisomerase II inhibitorEtoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell. Learn More -
Genistin (Genistoside)
Catalog No. A10426 Genistin is an isoflavone found in a number of dietary plants like soy and kudzu. It was shown to stimulate estrogen-dependent breast cancer cell growth in vivo. Learn More -
Idarubicin HCl
Catalog No. A10465 Topoisomerase inhibitorIdarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin. Learn More -
Clorobiocin
Catalog No. A15467 -
SW044248
Catalog No. A15837 TOP1 inhibitorSW044248 is a novel noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells. Learn More -
Rubitecan
Catalog No. A22040 topoisomerase I inhibitorRubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. Learn More -
Teniposide
Catalog No. A10907 Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Learn More -
Dexrazoxane
Catalog No. A17714 topoisomerase IIα inhibitorDexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. Learn More -
Zoliflodacin
Catalog No. A22032 DNA gyrase/topoisomerase inhibitorZoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Learn More -
Intoplicine
Catalog No. A20104 DNA topoisomerase I/II inhibitorIntoplicine is a DNA topoisomerase I and II inhibitor. Learn More -
Levofloxacin hydrate
Catalog No. A16167 topoisomerase II IV inhibitorLevofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Learn More -
Clinafloxacin
Catalog No. A16458 DNA gyrase and topoisomerase IV inhibitorClinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. Learn More -
Indotecan
Catalog No. A20979 Top1 inhibitorIndotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Learn More -
Pixantrone
Catalog No. A13022 Topoisomerase II inhibitorPixantrone is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Learn More -
Topotecan
Catalog No. A16815 Topoisomerase inhibitorTopotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. Learn More -
CL2-SN-38
Catalog No. A18945 DNA topoisomerase I inhibitorCL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. Learn More -
MAC glucuronide α-hydroxy lactone-linked SN-38
Catalog No. A18407 Topoisomerase I inhibitorMAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. Learn More -
Top1 inhibitor 1
Catalog No. A13304 human topoisomerase I (Top1) inhibitorTop1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM. Learn More -
TAS 103 2HCl
Catalog No. A14141 topoisomerase I/II inhibitorTAS 103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models Learn More -
(S)-10-Hydroxycamptothecin
Catalog No. A11997 Topoisomerase(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis. Learn More -
Norfloxacin (Norxacin)
Catalog No. A10652 Topoisomerase inhibitorNorfloxacin(Norxacin) is a broad-spectrum antibiotic. Learn More -
Marbofloxacin
Catalog No. A10557 Topoisomerase inhibitorMarbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group and acts by inhibiting bacterial DNA replication. Learn More -
Topotecan HCl (Hycamtin)
Catalog No. A10939 DNA topoisomerase I inhibitorTopotecan HCl (Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. Learn More -
Irinotecan HCl Trihydrate (Campto)
Catalog No. A10479 Topoisomerase inhibitorIrinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of topoisomerase 1 involved in cellular DNA replication and transcription. Learn More
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.