Catalog No.Inhibitor Name TopoisomeraseTopo ITopo IITopo IVOther
A10939Topotecan HCl
A10465Idarubicin HCl
Multicellular spheroids
A10194Daunorubicin HCl
A11999Betulinic acid
HIV-1,Aminopeptidase N
A10345Epirubicin HCl
A10596Mitoxantrone HCl
A10609Moxifloxacin HCl
A10479Irinotecan HCl Trihydrate

1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Pixantrone

    Catalog No. A13022
    Topoisomerase II inhibitor
    Pixantrone is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Learn More
  2. TAS 103 2HCl

    Catalog No. A14141
    topoisomerase I/II inhibitor
    TAS 103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models Learn More
  3. Voreloxin

    Catalog No. A14158
    Topoisomerase II inhibitor
    Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication Learn More
  4. Ametantrone

    Catalog No. A12569
    topoisomerase II inhibitor
    Ametantrone (AM) is a synthetic 9,10-anthracenedione bearing two (hydroxyethylamino)ethylamino residues at positions 1 and 4 along with other anthraquinones and anthracyclines. Learn More
  5. SN 38

    Catalog No. A12011
    DNA topoisomerase Inhibitor
    SN 38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor). Learn More
  6. Beta-Lapachone

    Catalog No. A13059
    DNA topoisomerase II inhibitor
    Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Learn More
  7. Ofloxacin (DL8280)

    Catalog No. A10666
    Topoisomerase inhibitor
    Ofloxacin is a synthetic broad-spectrum antimicrobial agent. Learn More
  8. Gatifloxacin

    Catalog No. A10419
    DNA gyrase/topoisomerase IV inhibitor
    Gatifloxacin is a fluoroquinolone antibiotic which inhibits bacterial DNA gyrase (IC50 = 0.109 ng/ml) and topoisomerase IV (IC50 = 13.8 ng/ml). Learn More
  9. Gimatecan

    Catalog No. A12856
    topoisomerase I inhibitor
    Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Learn More
  10. Amrubicin

    Catalog No. A12663
    Topoisomerase II inhibitor
    Amrubicin is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic. Learn More
  11. Flumequine

    Catalog No. A11861
    Topoisomerase II inhibitor
    Flumequine is a synthetic chemotherapeutic antibiotic which affecting mammalian chromosome and DNA unwinding at the level of gyrase/topoisomerases. Learn More
  12. Doxorubicin

    Catalog No. A14403
    Topoisomerase II inhibitor
    Doxorubicin is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. Learn More
  13. Nemorubicin

    Catalog No. A14363
    Topoisomerase II inhibitor
    Nemorubicin is an anticancer drug with IC50 value of 0.08 uM. It is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives. It works primarily through topoisomerase I inhibition. Learn More
  14. Ellipticine

    Catalog No. A13780
    DNA topoisomerase II inhibitor
    Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Learn More
  15. Clinafloxacin

    Catalog No. A16458
    DNA gyrase and topoisomerase IV inhibitor
    Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. Learn More
  16. Levofloxacin hydrate

    Catalog No. A16167
    topoisomerase II IV inhibitor
    Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Learn More
  17. Teniposide

    Catalog No. A10907
    Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Learn More
  18. SW044248

    Catalog No. A15837
    TOP1 inhibitor‎
    SW044248 is a novel noncanonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells. Learn More
  19. Clorobiocin

    Catalog No. A15467
    DNA Gyrase Inhibitor
    Clorobiocin is an aminocoumarin. Learn More
  20. Voreloxin Hydrochloride

    Catalog No. A15280
    Topoisomerase inhibitor
    Voreloxin Hcl is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II. Learn More
  21. ABT 492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro: Learn More
  22. BNS-22

    Catalog No. A13443
    Topo II inhibitor
    BNS-22 is a potent small molecule inhibitor of Topo II (IC50 2.8 M and 0.42 M for Topo II alpha and Topo II beta, respectively). Learn More
  23. NK314

    Catalog No. A13993
    Topoisomerase II inhibitor
    NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. Learn More
  24. CKD602

    Catalog No. A13656
    Topoisomerase I inhibitor
    CKD-602 is a topoisomerase I inhibitor. Learn More
  25. Pirarubicin

    Catalog No. A10735
    Topoisomerase II inhibitor
    Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II (topoisomerase II) and supressing DNA replication Learn More
  26. Mitoxantrone Hydrochloride

    Catalog No. A10596
    Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Learn More
  27. Exatecan mesylate

    Catalog No. A11231
    Topoisomerase I inhibitor
    Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. Learn More
  28. Topoisomerase inhibitor

    Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

    Learn More
  29. Amonafide (AS1413)

    Catalog No. A10071
    Topoisomerase inhibitor

    Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

    Learn More
  30. Adriamycin

    Catalog No. A10041
    topoisomerase II inhibitor

    Adriamycin is an anthracycline antibiotic, it works by intercalating DNA, while most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.

    Learn More
  31. ABT-492 (Delafloxacin)

    Catalog No. A10023
    Fluoroquinolone antibiotic
    ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens. Learn More
  32. Topoisomerase inhibitor
    Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of topoisomerase 1 involved in cellular DNA replication and transcription. Learn More
  33. Topotecan HCl (Hycamtin)

    Catalog No. A10939
    DNA topoisomerase I inhibitor
    Topotecan HCl (Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. Learn More
  34. Marbofloxacin

    Catalog No. A10557
    Topoisomerase inhibitor
    Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group and acts by inhibiting bacterial DNA replication. Learn More
  35. Moxifloxacin HCl

    Catalog No. A10609
    Topoisomerase inhibitor
    Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Learn More
  36. Norfloxacin (Norxacin)

    Catalog No. A10652
    Topoisomerase inhibitor
    Norfloxacin(Norxacin) is a broad-spectrum antibiotic. Learn More
  37. Camptothecin

    Catalog No. A10174
    Topoisomerase I inhibitor
    Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). Learn More
  38. Epirubicin HCl

    Catalog No. A10345
    Topoisomerase II inhibitor
    Epirubicin is a cell-permeable anthracycline antitumor antibiotic. It is a stereoisomer(4′-epi-isomer) of doxorubicin that exhibits reduced cardiotoxicity. It is used to inhibit topoisomerase II and DNA helicase activity. Learn More
  39. Etoposide (VP-16)

    Catalog No. A10373
    Topoisomerase II inhibitor
    Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell. Learn More
  40. Podophyllotoxin

    Catalog No. A10740
    Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin. Learn More
  41. Betulinic acid

    Catalog No. A11999
    Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties. Learn More
  42. (S)-10-Hydroxycamptothecin

    Catalog No. A11997
    (S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis. Learn More
  43. Pefloxacin mesylate

    Catalog No. A11902
    Pefloxacin mesylate is a synthetic chemotherapeutic agent and an antibacterial agent with IC5N/A of 6.7 nM. Learn More
  44. Sarafloxacin HCl

    Catalog No. A11659
    Topoisomerase inhibitor
    Sarafloxacin hydrochloride is a fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Learn More
  45. Balofloxacin

    Catalog No. A11658
    Topoisomerase inhibitor
    Balofloxacin is a quinolone antibiotic. The bactericidal action of Balofloxacin results from interference with the enqyme DNA gyrase which is needed for the synthesis of bacterial DNA. Balofloxacin is efficacious against Gram-negative bacteria. It also has enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae. Learn More
  46. Mitoxantrone

    Catalog No. A10595
    Mitoxantrone is a synthetic antineoplastic anthracenedione (IC50 = 0.42 mM). Learn More
  47. Irinotecan

    Catalog No. A10478
    Topoisomerase I inhibitor
    Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. Learn More
  48. Idarubicin HCl

    Catalog No. A10465
    Topoisomerase inhibitor
    Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin. Learn More
  49. Genistin (Genistoside)

    Catalog No. A10426
    Genistin is an isoflavone found in a number of dietary plants like soy and kudzu. It was shown to stimulate estrogen-dependent breast cancer cell growth in vivo. Learn More
  50. Antioxidant, antiangiogenic, antitumor agent
    (-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea. Learn More

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