Catalog No.Inhibitor Name FLT3Other
c-Kit (D816H),PDGFRα (V561D)
Abl (T315I),Abl,FGFR1
A10198Dovitinib Dilactic Acid
JAK2 (V617F),JAK2,TYK2
A12427TCS 359
A10352ENMD-2076 L-(*)-Tartaric acid
A14025AMG 925
Mer,Aurora B,RET
A11962TG-02 (SB1317)
A14411Gilteritinib (ASP2215)
A15003AST 487
Ret, c-Kit, KDR, c-Abl
A15520Pexidartinib (PLX3397)
Kit, CSF-1R

1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

29 Item(s)

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  1. AC220 (Quizartinib)

    Catalog No. A10027
    FLT3 inhibitor
    AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. Learn More
  2. TG-02 (SB1317)

    Catalog No. A11962
    FLT3 inhibitor
    TG-02 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Learn More
  3. G-749

    Catalog No. A14214
    FLT3 inhibitor
    G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y). Learn More
  4. Gilteritinib (ASP2215)

    Catalog No. A14411
    FLT3/Axl inhibitor
    Gilteritinib is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. Learn More
  5. AMG-925

    Catalog No. A14025
    Dual FLT3/CDK4 inhibitor
    AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More
  6. AST 487

    Catalog No. A15003
    RET kinase inhibitor
    AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret. Learn More
  7. Pexidartinib (PLX3397)

    Catalog No. A15520
    CSF1/Kit/FLT3 inhibitor
    Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Learn More
  8. SU5614

    Catalog No. A15548
    FLT3 inhibitor
    SU5614 is a potent and selective FLT3 inhibitor. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. Learn More
  9. UNC-2025

    Catalog No. A15904
    Dual MER/FLT3 inhibitor
    UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3. Learn More
  10. AC710 Mesylate

    Catalog No. A16246
    FLT3/KIT/PDGFRα/PDGFRβ inhibitor
    AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. Learn More
  11. BPR1J-097

    Catalog No. A16248
    FLT3 inhibitor
    BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities. Learn More
  12. FLT3-IN-1

    Catalog No. A16249
    FLT3 inhibitor
    FLT3-IN-1 is a novel potent and selective Flt3 inhibitor with IC50 of 10 nM; against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM. Learn More
  13. FLT3-IN-2

    Catalog No. A16250
    FLT3 inhibitor
    FLT3-IN-2 is potent FLT3 inhibitor. Learn More
  14. AZD 2932

    Catalog No. A14156
    mutil-targeted protein tyrosine kinase inhibitor
    AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. Learn More
  15. Pacritinib (SB1518)

    Catalog No. A12694
    JAK2/FLT3 inhibitor
    Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis. Learn More
  16. TCS 359

    Catalog No. A12427
    FLT3 inhibitor
    TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Learn More
  17. VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  18. R406 besylate

    Catalog No. A10769
    Syk Inhibitor
    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More
  19. Dovitinib (TKI-258)

    Catalog No. A11411
    RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  20. MP470 (MP-470, Amuvatinib)

    Catalog No. A10610
    RTK inhibitor
    MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor. Learn More
  21. Tandutinib (MLN518)

    Catalog No. A10887
    FLT3 Inhibitor
    Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis. Learn More
  22. ENMD-2076

    Catalog No. A10352
    Aurora A / FLT3 Inhibitor
    ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2. Learn More
  23. KW-2449

    Catalog No. A10508
    FLT3/FGFR/Bcr-Abl/Aurora Inhibitor
    KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. Learn More
  24. TG101209

    Catalog No. A11180
    JAK2 inhibitor

    TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

    Learn More
  25. RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  26. MK-2461

    Catalog No. A11753
    c-Met Inhibitor
    MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Learn More
  27. Go 6976

    Catalog No. A12419
    PKC inhibitor
    Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. Learn More
  28. R406 (Tamatinib)

    Catalog No. A10770
    Syk Inhibitor
    R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling. Learn More
  29. SB1317 (TG02)

    Catalog No. A13454
    CDK/JAK2/FLT3 inhibitor
    SB1317 is a potent inhibitor of Cyclin dependent kinases (CDKs), FMS-like tyrosine kinase-3 (FLT3) and Janus kinase 2 (JAK2) with IC50 values of 13nM, 56nM and 73nM for CDK2, JAK2 and FLT3, respectively. Learn More

29 Item(s)

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