c-Kit

Inhibitory Selectivity
Catalog No.Inhibitor Name c-KitOther
A10290Dasatinib
***
Abl,Src
A10468Imatinib Mesylate
**
PDGFR,v-Abl
A10996Cabozantinib
***
VEGFR2/KDR,c-Met,VEGFR3/FLT4
A10103Axitinib
****
VEGFR1/FLT1,VEGFR2/Flk1,VEGFR2/KDR
A10699Pazopanib HCl
*
VEGFR1,VEGFR2,VEGFR3
A11411Dovitinib
****
FLT3,FGFR1,VEGFR3/FLT4
A10967Vatalanib 2HCl
*
VEGFR2/KDR,VEGFR1/FLT1,VEGFR2/Flk1
A10558Masitinib
*
Lyn B,PDGFRα,PDGFRβ
A10101Tivozanib
**
VEGFR2,VEGFR3,EphB2
A10610Amuvatinib
***
PDGFRα (V561D),FLT3 (D835Y)
A10608Motesanib Diphosphate
***
VEGFR1,VEGFR2,VEGFR2/Flk1
A10679OSI-930
**
FLT1,KDR,CSF-1R
A10502Ki8751
**
VEGFR2,PDGFRα,FGFR2
A10903Telatinib
****
VEGFR3,VEGFR2,PDGFRα
A11518Pazopanib
*
VEGFR1,VEGFR2,VEGFR3
A10198Dovitinib Dilactic Acid
****
FLT3,FGFR1,VEGFR3/FLT4
A16320Dasatinib Monohydrate
***
Abl ,Src
A14156AZD2932
***
PDGFRβ,Flt3,VEGFR-2
A10880Sunitinib Malate
FLT3,PDGFRβ,VEGFR2
A15062DCC-2618
***
PDGFRα, PDGFRβ
A15519PLX647
***
Fms
A15520Pexidartinib (PLX3397)
***
CSF-1R, Flt-3

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A15003

AST 487

RET kinase inhibitor
AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
A10103 SALE

Axitinib

VEGFR inhibitor
Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
A14156

AZD 2932

mutil-targeted protein tyrosine kinase inhibitor
AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.
A10290 SALE

Dasatinib (BMS-354825)

Abl-Src inhibitor
Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.
A16320

Dasatinib Monohydrate

-
Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM, respectively.
A15062

DCC-2618

C-Kit/PDGFR inhibitor
DCC-2618 is a small molecule inhibitor of c-Kit and PDGFR with IC50s of 6 nM/30 nM/13 nM for c-Kit/PDGFRα/PDGFRβ respectively.
A11411 SALE

Dovitinib (TKI-258)

RTK inhibitor
Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
A10198 SALE

Dovitinib Dilactic acid (TKI258 Dilactic acid)

RTK inhibitor
Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
A16258

Flumatinib

multi-kinase inhibitor
Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRbeta and c-Kit respectively.
A13530

Flumatinib mesylate

c-Abl/c-Kit/PDGRFβ inhibitor
Flumatinib mesylate can reduce the expression of C-MYC, HIF-1 a and VEGF in U266 cell line in a time- and dose-dependent manners, so flumatinib mesylate may become a new drug for MM therapy.
A10259 SALE

Imatinib (Gleevec)

PDGFR inhibitor
Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor.
A10468 SALE

Imatinib Mesylate

Bcr-Abl inhibitor
Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
A11472 SALE

Ki 20227

M-CSFR, CSF1R inhibitor
Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R).
A10502 SALE

Ki8751

VEGFR-2 inhibitor
Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.
A10558 SALE

Masitinib ( AB1010)

c-Kit inhibitor
Masitinib (AB1010) is a protein tyrosine kinase inhibitor.
A15152

Masitinib mesylate

KIT/PDGFR inhibitor
Masitinib mesylate is a novel inhibitor for Kit and PDGFR??/?? with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms.
A10608

Motesanib Diphosphate (AMG-706)

VEGFR inhibitor
Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.
A10610

MP470 (MP-470, Amuvatinib)

RTK inhibitor
MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor.
A15182

N-Desethyl Sunitinib

VEGFR/PDGFRβ/KIT inhibitor
N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFR?? and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR?? and KIT respectively).
A10679 SALE

OSI-930

c-Kit/VEGFR Inhibitor
OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.
A11518 SALE

Pazopanib (GW-786034)

VEGFR inhibitor
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
A10699 SALE

Pazopanib HCl (GW786034)

VEGFR/PDGFR/FGFR inhibitor
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
A15520 SALE

Pexidartinib (PLX3397)

CSF1/Kit/FLT3 inhibitor
Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
A15519

PLX647

FMS/KIT inhibitor
PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively.
A10250 SALE

Regorafenib (BAY 73-4506)

VEGFR inhibitor
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.

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