HSP

Catalog No.Inhibitor Name HSP70HSP90HSP90αHSP90βHSP105Other
A10010Tanespimycin
***
A10659Luminespib
***
***
***
A10011Alvespimycin HCl
*
A11402Ganetespib
***
A10143BIIB021
****
A11062Onalespib
***
A11025Geldanamycin
*
p185
A10660NVP-BEP800
*
*
A11189SNX-2112
**
**
**
A11074PF-04929113
**
HER2
A11195KW-2478
****
A11251XL888
**
A13351VER155008
*
A13817VER-50589
***
***
A14282CH5138303
****
****
A13812VER-49009
**
**
A14292NMS-E973
***
A11130PU-H71
*
A12850HSP990
****
****
****
A14389KNK437
A11131MPC-3100
*
A11269IPI-504 (Retaspimycin HCl)
A11272IPI-493
**
A12388MKT 077
A12648CUDC-305 (DEBIO-0932 )
A16050Macbecin I
A16053TRC 051384
A16056EC 144
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. 17-AAG (KOS953)

    Catalog No. A10010
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    HSP90 inhibitor
    17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90. Learn More
  2. MKT 077

    Catalog No. A12388
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    HSP70 Inhibitor
    Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Learn More
  3. VER-50589

    Catalog No. A13817
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    Hsp90 inhibitor
    VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM. Learn More
  4. VER 155008

    Catalog No. A13351
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    HSP 70 inhibitor
    VER 155008 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). Learn More
  5. Geranylgeranylacetone

    Catalog No. A13667
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    Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Learn More
  6. VER-49009

    Catalog No. A13812
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    Hsp90 inhibitor
    VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. Learn More
  7. CH5138303

    Catalog No. A14282
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    HSP90 inhibitor
    CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. Learn More
  8. NMS-E973

    Catalog No. A14292
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    HSP90 inhibitor
    NMS-E973 is a potent and selective Hsp90 inhibitor. Learn More
  9. Alvespimycin

    Catalog No. A14990
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    Hsp90 inhibitor
    Alvespimycin is a selective Hsp90 inhibitor with a GI50 of 53 nM. Learn More
  10. PU-WS13

    Catalog No. A14129
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    Grp94 Inhibitor
    PU-WS13 is a potent, Grp94-specific Hsp90 inhibitor of the purine scaffold class. PU-WS13 is a cell-permeable inhibitor of Grp94 with EC50 of 220 nM. Learn More
  11. Macbecin I

    Catalog No. A16050
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    HSP90 inhibitor
    Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity with IC50 value of μM by binding to the ATP-binding site. Learn More
  12. Rocaglamide

    Catalog No. A12765
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    Heat shock reporter
    Rocaglamide is the first cyclopenta[b]benzofuran derivative (flavagline), isolated from Aglaia elliptifolia in 1982 by King and colleagues based on its antileukemic activity. Learn More
  13. KNK437

    Catalog No. A14389
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    pan-HSP inhibitor
    KNK437, dose-dependently inhibited the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells. Learn More
  14. Gedunin

    Catalog No. A16034
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    HSP90 inhibitor
    Gedunin, a naturally occurring Hsp90 inhibitor, is tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica). Learn More
  15. TRC 051384

    Catalog No. A16053
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    HSP70 inducer
    TRC 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (HSP70) [1]. Induction of HSP70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia. Learn More
  16. EC 144

    Catalog No. A16056
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    HSP90 inhibitor
    EC 144 is a potent inhibitor of the heat shock protein 90 and was found to be effective in tumor growth suppression. Learn More
  17. KRIBB11

    Catalog No. A16347
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    HSF inhibitor
    KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor, with IC50 of 1.2 μM. Learn More
  18. HSP-990

    Catalog No. A12850
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    HSP90 Inhibitor
    HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Learn More
  19. IPI-493

    Catalog No. A11272
    HSP90 inhibitor
    IPI-493 is a potent and orally bioavailable HSP90 inhibitor with Ki of 21 nM. Learn More
  20. CUDC-305 (DEBIO-0932 )

    Catalog No. A12648
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    HSP90 inhibitor
    Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Learn More
  21. AUY922 (Luminespib, NVP-AUY922)

    Catalog No. A10659
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    HSP90 Inhibitor
    AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM. Learn More
  22. NVP-BEP800

    Catalog No. A10660
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    HSP90 Inhibitor
    NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH2-terminal ATP-binding pocket of Hsp90. Learn More
  23. BIIB021

    Catalog No. A10143
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    HSP90 inhibitor
    BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival. Learn More
  24. Onalespib (AT13387)

    Catalog No. A11062
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    HSP90 Inhibitor
    AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Learn More
  25. Geldanamycin

    Catalog No. A11025
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    Hsp90 inhibitor
    Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity. Learn More
  26. PF-04929113 (SNX-5422)

    Catalog No. A11074
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    Hsp90 inhibitor
    PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor. Learn More
  27. Ganetespib (STA-9090)

    Catalog No. A11402
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    Hsp90 inhibitor
    Ganetespib is a potent, synthetic, small molecule inhibitor of Hsp90, a chaperone protein that is essential to the function of certain other proteins that drive the growth, proliferation, and survival of many different types of cancer. Learn More
  28. 17-DMAG HCl (Alvespimycin)

    Catalog No. A10011
    Hsp90 inhibitor
    17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG. Learn More
  29. SNX-2112

    Catalog No. A11189
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    Hsp90 inhibitor

    SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

    Learn More
  30. KW-2478

    Catalog No. A11195
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    HSP90 inhibitor

    KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.

    Learn More
  31. MPC-3100

    Catalog No. A11131
    Hsp90 inhibitor
    MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Learn More
  32. PU-H71

    Catalog No. A11130
    Hsp90 Inhibitor
    PU-H71 is a potent Hsp90 inhibitor (IC50 = 50 nM). Learn More
  33. Elesclomol (STA-4783)

    Catalog No. A10343
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    Elesclomol induces oxidative stress by provoking a buildup of reactive oxygen species within cancer cells. Learn More
  34. IPI-504 (Retaspimycin HCl)

    Catalog No. A11269
    Hsp90 inhibitor
    IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Learn More
  35. Radicicol

    Catalog No. A11768
    Hsp90/SRC/COX-2 Inhibitor
    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2 Learn More
  36. XL-888

    Catalog No. A11251
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    HSP90 Inhibitor
    XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Learn More
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    TRC051384

    Catalog No. A17159
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    Hsp70 inducer
    TRC051384 is an inducer of heat shock protein Hsp70. Learn More

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