Raf

Target
  1. VEGFR2 (1)
Actions
  1. Inhibitor (23)


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Catalog No. Product Name Product Information
A11063

AZ628

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
A14122

B-Raf-inhibitor 1

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively
A13119

Balamapimod (MKI-833)

N/A
A11333

BRAF inhibitor

0
A15040

CEP-32496 hydrochloride

CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM, respectively.
A15058

Dabigatran ethyl ester

Dabigatran ethyl ester, which is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity.
A11381

Dabrafenib (GSK2118436A)

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
A15059

Dabrafenib Mesylate

Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively.
A12891

Diazepinomicin

Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity.
A10420

GDC-0879

GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM).
A11436

GW 5074

GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor
A16022

HG6-64-1

HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738.
A15843

KM 11060

KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity
A12578

Kobe2602

Kobe2602 is an analog of Kobe0065. Both compounds exhibit inhibitory activity toward H-Ras?GTP-c-Raf-1 binding both in vivo and in vitro.
A13525

L-779450

L-779450 is a raf kinase inhibitor, a potential treatment for neurotraumatic diseases.
A13226

LGX 818 (Encorafenib)

LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.
A11211

ML 786 dihydrochloride

ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively).
A11240

MLN2480 (BIIB-024)

MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials.
A10661

NVP-BHG712

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
A12739

PF-04880594

PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells.
A10002

PLX-4720

PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.
A10739

PLX4032 (Vemurafenib)

PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
A15855

PLX7904

PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
A10773

RAF265 (CHIR-265)

RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.
A10774

Raf265 derivative

Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM.

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