Raf

Target
  1. VEGFR2 (1)
Actions
  1. Inhibitor (28)


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Catalog No. Product Name Application Product Information
A11063

AZ628

Raf inhibitor
AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
A14122

B-Raf-inhibitor 1

B-Raf inhibitor
B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively
A13119

Balamapimod (MKI-833)

Ras/Raf/MEK inhibitor
N/A
A11333

BRAF inhibitor

-
0
A15040

CEP-32496 hydrochloride

Raf Inhibitor
CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM, respectively.
A15058

Dabigatran ethyl ester

Raf inhibitor
Dabigatran ethyl ester, which is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity.
A11381

Dabrafenib (GSK2118436A)

Raf inhibitor
Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
A15059

Dabrafenib Mesylate

Raf inhibitor
Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively.
A12891

Diazepinomicin

RAS/RAF/MAPK inhibitor
Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity.
A10420

GDC-0879

B-Raf inhibitor
GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM).
A11436

GW 5074

Raf Inhibitor
GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor
A16022

HG6-64-1

B-Raf inhibitor
HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738.
A15843

KM 11060

F508del-CFTR trafficking corrector
KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity
A12578

Kobe2602

-
Kobe2602 is an analog of Kobe0065. Both compounds exhibit inhibitory activity toward H-Ras?GTP-c-Raf-1 binding both in vivo and in vitro.
A13525

L-779450

Raf inhibitor
L-779450 is a raf kinase inhibitor, a potential treatment for neurotraumatic diseases.
A13226

LGX 818 (Encorafenib)

RAF inhibitor
LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.
A11211

ML 786 dihydrochloride

Raf inhibitor
ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively).
A11240

MLN2480 (BIIB-024)

pan-Raf inhibitor
MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials.
A10661

NVP-BHG712

EphB4 inhibitor
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
A12739

PF-04880594

RAF inhibitor
PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells.
A10002

PLX-4720

Raf inhibitor
PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.
A10739

PLX4032 (Vemurafenib)

Raf inhibitor
PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
A15855

PLX7904

Raf inhibitor
PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
A10773

RAF265 (CHIR-265)

RAF/VEGFR Inhibitor
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.
A10774

Raf265 derivative

RAF/VEGFR Inhibitor
Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM.

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