HDAC

Catalog No.Inhibitor Name HDAC HDAC1 HDAC2 HDAC3 HDAC4HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2
A10979Vorinostat
****
A10611Entinostat
**
*
A10518Panobinostat
****
A10947Trichostatin A
****
A10586Mocetinostat
**
**
*
*
A10122Belinostat
***
A11920Romidepsin
***
***
A10560MC1568
*
A11042Tubastatin A HCl
*
***
A10488Givinostat
****
****
A10516Dacinostat
***
A10246CUDC-101
****
****
***
****
***
***
****
**
**
**
***
A10830Pracinostat
***
**
***
***
***
*
**
**
**
***
**
A11152PCI-34051
*
*
****
*
A10337Droxinostat
*
*
*
A10700Abexinostat
****
***
****
***
**
***
A13218RGFP966
**
A11037AR-42
***
A11940Ricolinostat
**
***
***
*
*
****
*
**
A11964Tacedinaline
*
*
*
**
A11153CUDC-907
****
****
****
**
*
***
**
**
****
****
A11355M344
**
A10954Tubacin
****
A13139RG2833
***
****
A12556Resminostat
***
***
**
A15489BRD73954
*
***
**
A11361BG45
*
*
**
A143544SC-202
*
*
*
A16431CAY10603
**
****
A14341LMK-235
***
****
A14032Nexturastat A
****
A14128TMP269
**
**
***
***
A14197HPOB
*
*
*
***
*
*
A12722Scriptaid
A12616Tasquinimod
A11042Tubastatin A
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. ACY-241

    Catalog No. A12758
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    HDAC6 inhibitor
    ACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More
  2. LAQ824 (NVP-LAQ824, Dacinostat)

    Catalog No. A10516
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    HDAC Inhibitor
    LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Learn More
  3. ACY-1215 (Rocilinostat)

    Catalog No. A11940
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    HDAC6 inhibitor
    ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Learn More
  4. CI994 (Tacedinaline)

    Catalog No. A11964
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    HDAC Inhibitor
    CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells. Learn More
  5. Romidepsin (FK228 ,Depsipeptide)

    Catalog No. A11920
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    HDAC inhibitor
    Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively. Learn More
  6. Apicidin

    Catalog No. A12745
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    HDAC inhibitor
    Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity. Learn More
  7. RGFP966

    Catalog No. A13218
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    HDAC3 inhibitor
    RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. Learn More
  8. BRD9757

    Catalog No. A12911
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    HDAC6 inhibitor
    BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. Learn More
  9. Resminostat

    Catalog No. A12556
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    HDAC inhibitor
    Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. Learn More
  10. Scriptaid

    Catalog No. A12722
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    HDAC inhibitor
    Scriptaid is an HDAC inhibitor (histone deacetylase). Learn More
  11. TMP 269

    Catalog No. A14128
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    HDAC inhibitor
    TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Learn More
  12. RG2833 (RGFP109)

    Catalog No. A13139
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    HDAC inhibitor
    RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. Learn More
  13. BRD73954

    Catalog No. A15489
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    HDAC inhibitor
    BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively). Learn More
  14. Resminostat hydrochloride

    Catalog No. A15220
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    HDAC inhibitor
    Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More
  15. KD 5170

    Catalog No. A15354
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    HDAC inhibitor
    KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More
  16. NCH 51

    Catalog No. A15355
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    HDAC Inhibitor
    NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM. Learn More
  17. NSC 3852

    Catalog No. A15356
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    HDAC Inhibitor
    NSC 3852 is an HDAC (histone deacetylase) inhibitor. Learn More
  18. Tubacin

    Catalog No. A10954
    HDAC6 inhibitor
    Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. Learn More
  19. Parthenolide ((-)-Parthenolide)

    Catalog No. A10698
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    Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Learn More
  20. CUDC-907 (Fimepinostat)

    Catalog No. A11153
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    PI3K/HDAC inhibitor
    CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses. Learn More
  21. Trichostatin-A (TSA)

    Catalog No. A10947
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    HDAC Inhibitor
    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More
  22. Belinostat (PXD101)

    Catalog No. A10122
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    HDAC inhibitor
    Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Learn More
  23. LBH589 (Panobinostat)

    Catalog No. A10518
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    HDAC Inhibitor
    LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM. Learn More
  24. MC1568

    Catalog No. A10560
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    HDAC Inhibitor
    MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis. Learn More
  25. CUDC-101

    Catalog No. A10246
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    HDAC inhibitor
    CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2. Learn More
  26. MGCD0103 (Mocetinostat)

    Catalog No. A10586
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    HDAC Inhibitor
    MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11. Learn More
  27. MS-275 (Entinostat)

    Catalog No. A10611
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    HDAC inhibitor
    MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More
  28. Vorinostat (SAHA)

    Catalog No. A10979
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    HDAC inhibitor
    Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Learn More
  29. ITF2357 (Givinostat)

    Catalog No. A10488
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    HDAC inhibitor
    ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Learn More
  30. SB939 ( Pracinostat )

    Catalog No. A10830
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    HDAC inhibitor
    SB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay. Learn More
  31. Tubastatin A HCl

    Catalog No. A11042
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    HDAC6 inhibitor
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Learn More
  32. JNJ-26481585 (Quisinostat)

    Catalog No. A10492
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    HDAC inhibitor
    JNJ-26481585 (Quisinostat) is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L). Learn More
  33. Pyroxamide (NSC 696085)

    Catalog No. A10764
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    HDAC Inhibitor
    Pyroxamide (NSC 696085) is a potent inhibitor of affinity-purified HDAC1 and causes the accumulation of acetylated core histones in MEL cells cultured with the agent. Learn More
  34. PCI-34051

    Catalog No. A11152
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    HDAC inhibitor
    PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms. Learn More
  35. PCI-24781 (Abexinostat)

    Catalog No. A10700
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    HDAC Inhibitor
    PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor. Learn More
  36. AR-42 (HDAC-42)

    Catalog No. A11037
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    HDAC inhibitor
    AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Learn More
  37. Droxinostat

    Catalog No. A10337
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    HDAC inhibitor
    Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively. Learn More
  38. Tinostamustine (EDO-S101)

    Catalog No. A18342
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    HDAC inhibitor
    EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. Learn More
  39. HDAC8-IN-1

    Catalog No. A17091
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    HDAC8 inhibitor
    HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. Learn More
  40. SR-4370

    Catalog No. A16899
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    HDAC inhibitor
    SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. Learn More
  41. CHDI-390576

    Catalog No. A18899
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    HDAC inhibitor
    CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. Learn More
  42. SW-100

    Catalog No. A18947
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    HDAC6 inhibitor
    SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. Learn More
  43. SKLB-23bb

    Catalog No. A18339
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    HDAC6 inhibitor
    SKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. Learn More
  44. Valproic acid

    Catalog No. A17323
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    HDAC inhibitor
    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Learn More
  45. Tucidinostat (Chidamide)

    Catalog No. A17861
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    HDAC inhibitor
    Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. Learn More
  46. CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More
  47. AES-135

    Catalog No. A19087
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    HDAC inhibitor
    AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity. Learn More
  48. MPT0E028

    Catalog No. A18982
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    HDAC inhibitor
    MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Learn More
  49. SS-208

    Catalog No. A18952
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    HDAC6 inhibitor
    SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma. Learn More
  50. Ac-Lys-AMC

    Catalog No. A18461
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    fluorescent substrate for HDAC
    Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs. Learn More

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