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| Catalog No. | Inhibitor Name | HDAC | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | HDAC10 | HDAC11 | HD1 | HD2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10979 | Vorinostat | **** | |||||||||||||
| A10611 | Entinostat | ** | * | ||||||||||||
| A10518 | Panobinostat | **** | |||||||||||||
| A10947 | Trichostatin A | **** | |||||||||||||
| A10586 | Mocetinostat | ** | ** | * | * | ||||||||||
| A10122 | Belinostat | *** | |||||||||||||
| A11920 | Romidepsin | *** | *** | ||||||||||||
| A10560 | MC1568 | * | |||||||||||||
| A11042 | Tubastatin A HCl | * | *** | ||||||||||||
| A10488 | Givinostat | **** | **** | ||||||||||||
| A10516 | Dacinostat | *** | |||||||||||||
| A10246 | CUDC-101 | **** | **** | *** | **** | *** | *** | **** | ** | ** | ** | *** | |||
| A10830 | Pracinostat | *** | ** | *** | *** | *** | * | ** | ** | ** | *** | ** | |||
| A11152 | PCI-34051 | * | * | **** | * | ||||||||||
| A10337 | Droxinostat | * | * | * | |||||||||||
| A10700 | Abexinostat | **** | *** | **** | *** | ** | *** | ||||||||
| A13218 | RGFP966 | ** | |||||||||||||
| A11037 | AR-42 | *** | |||||||||||||
| A11940 | Ricolinostat | ** | *** | *** | * | * | **** | * | ** | ||||||
| A11964 | Tacedinaline | * | * | * | ** | ||||||||||
| A11153 | CUDC-907 | **** | **** | **** | ** | * | *** | ** | ** | **** | **** | ||||
| A11355 | M344 | ** | |||||||||||||
| A10954 | Tubacin | **** | |||||||||||||
| A13139 | RG2833 | *** | **** | ||||||||||||
| A12556 | Resminostat | *** | *** | ** | |||||||||||
| A15489 | BRD73954 | * | *** | ** | |||||||||||
| A11361 | BG45 | * | * | ** | |||||||||||
| A14354 | 4SC-202 | * | * | * | |||||||||||
| A16431 | CAY10603 | ** | **** | ||||||||||||
| A14341 | LMK-235 | *** | **** | ||||||||||||
| A14032 | Nexturastat A | **** | |||||||||||||
| A14128 | TMP269 | ** | ** | *** | *** | ||||||||||
| A14197 | HPOB | * | * | * | *** | * | * | ||||||||
| A12722 | Scriptaid | ||||||||||||||
| A12616 | Tasquinimod | ||||||||||||||
| A11042 | Tubastatin A | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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MS-275 (Entinostat)
Catalog No. A10611 HDAC inhibitorMS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More -
Trichostatin-A (TSA)
Catalog No. A10947 HDAC InhibitorTrichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More -
Belinostat (PXD101)
Catalog No. A10122 HDAC inhibitorBelinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Learn More -
LBH589 (Panobinostat)
Catalog No. A10518 HDAC InhibitorLBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM. Learn More -
MC1568
Catalog No. A10560 HDAC InhibitorMC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis. Learn More -
CUDC-101
Catalog No. A10246 HDAC inhibitorCUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2. Learn More -
MGCD0103 (Mocetinostat)
Catalog No. A10586 HDAC InhibitorMGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11. Learn More -
Vorinostat (SAHA)
Catalog No. A10979 HDAC inhibitorVorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Learn More -
ITF2357 (Givinostat)
Catalog No. A10488 HDAC inhibitorITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Learn More -
Droxinostat
Catalog No. A10337 HDAC inhibitorDroxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively. Learn More -
AR-42 (HDAC-42)
Catalog No. A11037 HDAC inhibitorAR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Learn More -
PCI-24781 (Abexinostat)
Catalog No. A10700 HDAC InhibitorPCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor. Learn More -
Tubastatin A HCl
Catalog No. A11042 HDAC6 inhibitorTubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Learn More -
SB939 ( Pracinostat )
Catalog No. A10830 HDAC inhibitorSB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay. Learn More -
JNJ-26481585 (Quisinostat)
Catalog No. A10492 HDAC inhibitorJNJ-26481585 (Quisinostat) is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L). Learn More -
Pyroxamide (NSC 696085)
Catalog No. A10764 HDAC InhibitorPyroxamide (NSC 696085) is a potent inhibitor of affinity-purified HDAC1 and causes the accumulation of acetylated core histones in MEL cells cultured with the agent. Learn More -
PCI-34051
Catalog No. A11152 HDAC inhibitorPCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms. Learn More -
CUDC-907 (Fimepinostat)
Catalog No. A11153 PI3K/HDAC inhibitorCUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses. Learn More -
Parthenolide ((-)-Parthenolide)
Catalog No. A10698 Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Learn More -
Tubacin
Catalog No. A10954 HDAC6 inhibitorTubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. Learn More -
LAQ824 (NVP-LAQ824, Dacinostat)
Catalog No. A10516 HDAC InhibitorLAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Learn More -
ACY-1215 (Rocilinostat)
Catalog No. A11940 HDAC6 inhibitorACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Learn More -
CI994 (Tacedinaline)
Catalog No. A11964 HDAC InhibitorCI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells. Learn More -
Romidepsin (FK228 ,Depsipeptide)
Catalog No. A11920 HDAC inhibitorRomidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively. Learn More -
Apicidin
Catalog No. A12745 HDAC inhibitorApicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity. Learn More -
RGFP966
Catalog No. A13218 HDAC3 inhibitorRGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. Learn More -
BRD9757
Catalog No. A12911 HDAC6 inhibitorBRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. Learn More -
Resminostat
Catalog No. A12556 HDAC inhibitorResminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. Learn More -
Scriptaid
Catalog No. A12722 -
TMP 269
Catalog No. A14128 HDAC inhibitorTMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Learn More -
RG2833 (RGFP109)
Catalog No. A13139 HDAC inhibitorRG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. Learn More -
BRD73954
Catalog No. A15489 HDAC inhibitorBRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively). Learn More -
Resminostat hydrochloride
Catalog No. A15220 HDAC inhibitorResminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More -
KD 5170
Catalog No. A15354 HDAC inhibitorKD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More -
NCH 51
Catalog No. A15355 HDAC InhibitorNCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM. Learn More -
NSC 3852
Catalog No. A15356 -
R306465
Catalog No. A15437 HDAC inhibitorR306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. Learn More -
Citarinostat (ACY-241)
Catalog No. A12758 HDAC6 inhibitorACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More -
ACY-738
Catalog No. A15934 HDAC6 inhibitorACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. Learn More -
CRA-026440
Catalog No. A12179 -
Valproic acid sodium salt
Catalog No. A10855 HDAC inhibitorValproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Learn More -
JAK/HDAC-IN-1
Catalog No. A13362 JAK2/HDAC dual inhibitorJAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. Learn More -
Sodium phenylbutyrate
Catalog No. A16714 HDAC/ER stress inhibitorSodium phenylbutyrate is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Learn More -
Tubastatin A
Catalog No. A16770 HDAC6 inhibitorTubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Learn More -
CG-200745
Catalog No. A20939 HDAC inhibitorCG-200745 is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Learn More -
Givinostat
Catalog No. A21126 HDAC inhibitorGivinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More -
HDAC-IN-7
Catalog No. A21252 HDAC1/2/3/10 inhibitorHDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. Learn More -
Givinostat hydrochloride
Catalog No. A21487 HDAC inhibitorGivinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More -
Belinostat
Catalog No. A21772 HDAC inhibitorBelinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. Learn More -
Sulforaphane
Catalog No. A21984 HDAC inhibitorSulforaphane activates Nrf2 and inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling. Sulforaphane has shown anti-cancer and anti-inflammatory activities. Learn More
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