HDAC

Catalog No.Inhibitor Name HDAC HDAC1 HDAC2 HDAC3 HDAC4HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2
A10979Vorinostat
****
A10611Entinostat
**
*
A10518Panobinostat
****
A10947Trichostatin A
****
A10586Mocetinostat
**
**
*
*
A10122Belinostat
***
A11920Romidepsin
***
***
A10560MC1568
*
A11042Tubastatin A HCl
*
***
A10488Givinostat
****
****
A10516Dacinostat
***
A10246CUDC-101
****
****
***
****
***
***
****
**
**
**
***
A10830Pracinostat
***
**
***
***
***
*
**
**
**
***
**
A11152PCI-34051
*
*
****
*
A10337Droxinostat
*
*
*
A10700Abexinostat
****
***
****
***
**
***
A13218RGFP966
**
A11037AR-42
***
A11940Ricolinostat
**
***
***
*
*
****
*
**
A11964Tacedinaline
*
*
*
**
A11153CUDC-907
****
****
****
**
*
***
**
**
****
****
A11355M344
**
A10954Tubacin
****
A13139RG2833
***
****
A12556Resminostat
***
***
**
A15489BRD73954
*
***
**
A11361BG45
*
*
**
A143544SC-202
*
*
*
A16431CAY10603
**
****
A14341LMK-235
***
****
A14032Nexturastat A
****
A14128TMP269
**
**
***
***
A14197HPOB
*
*
*
***
*
*
A12722Scriptaid
A12616Tasquinimod
A11042Tubastatin A
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. ACY-241

    Catalog No. A12758
    HDAC6 inhibitor
    ACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More
  2. HDAC Inhibitor
    LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Learn More
  3. ACY-1215 (Rocilinostat)

    Catalog No. A11940
    HDAC6 inhibitor
    ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. Learn More
  4. CI994 (Tacedinaline)

    Catalog No. A11964
    HDAC Inhibitor
    CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells. Learn More
  5. HDAC inhibitor
    Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively. Learn More
  6. Apicidin

    Catalog No. A12745
    HDAC inhibitor
    Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity. Learn More
  7. RGFP966

    Catalog No. A13218
    HDAC3 inhibitor
    RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. Learn More
  8. BRD9757

    Catalog No. A12911
    HDAC6 inhibitor
    BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6. Learn More
  9. Resminostat

    Catalog No. A12556
    HDAC inhibitor
    Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. Learn More
  10. Scriptaid

    Catalog No. A12722
    HDAC inhibitor
    Scriptaid is an HDAC inhibitor (histone deacetylase). Learn More
  11. TMP 269

    Catalog No. A14128
    HDAC inhibitor
    TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Learn More
  12. RG2833 (RGFP109)

    Catalog No. A13139
    HDAC inhibitor
    RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. Learn More
  13. BRD73954

    Catalog No. A15489
    HDAC inhibitor
    BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively). Learn More
  14. Resminostat hydrochloride

    Catalog No. A15220
    HDAC inhibitor
    Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More
  15. KD 5170

    Catalog No. A15354
    HDAC inhibitor
    KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More
  16. NCH 51

    Catalog No. A15355
    HDAC Inhibitor
    NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM. Learn More
  17. NSC 3852

    Catalog No. A15356
    HDAC Inhibitor
    NSC 3852 is an HDAC (histone deacetylase) inhibitor. Learn More
  18. Tubacin

    Catalog No. A10954
    HDAC6 inhibitor
    Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. Learn More
  19. Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Learn More
  20. CUDC-907

    Catalog No. A11153
    HDAC inhibitor
    CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses. Learn More
  21. MS-275 (Entinostat)

    Catalog No. A10611
    HDAC inhibitor
    MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More
  22. Trichostatin-A (TSA)

    Catalog No. A10947
    HDAC Inhibitor
    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More
  23. Belinostat (PXD101)

    Catalog No. A10122
    HDAC inhibitor
    Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Learn More
  24. LBH589 (Panobinostat)

    Catalog No. A10518
    HDAC Inhibitor
    LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM. Learn More
  25. MC1568

    Catalog No. A10560
    HDAC Inhibitor
    MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis. Learn More
  26. CUDC-101

    Catalog No. A10246
    HDAC inhibitor
    CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2. Learn More
  27. MGCD0103 (Mocetinostat)

    Catalog No. A10586
    HDAC Inhibitor
    MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11. Learn More
  28. Vorinostat (SAHA)

    Catalog No. A10979
    HDAC inhibitor
    Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Learn More
  29. ITF2357 (Givinostat)

    Catalog No. A10488
    HDAC inhibitor
    ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Learn More
  30. Droxinostat

    Catalog No. A10337
    HDAC inhibitor
    Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively. Learn More
  31. PCI-34051

    Catalog No. A11152
    HDAC inhibitor
    PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms. Learn More
  32. Pyroxamide (NSC 696085)

    Catalog No. A10764
    HDAC Inhibitor
    Pyroxamide (NSC 696085) is a potent inhibitor of affinity-purified HDAC1 and causes the accumulation of acetylated core histones in MEL cells cultured with the agent. Learn More
  33. JNJ-26481585

    Catalog No. A10492
    HDAC inhibitor
    JNJ-26481585 is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L). Learn More
  34. SB939 ( Pracinostat )

    Catalog No. A10830
    HDAC inhibitor
    SB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay. Learn More
  35. Tubastatin A HCl

    Catalog No. A11042
    HDAC6 inhibitor
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Learn More
  36. PCI-24781 (Abexinostat)

    Catalog No. A10700
    HDAC Inhibitor
    PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor. Learn More
  37. AR-42 (HDAC-42)

    Catalog No. A11037
    HDAC inhibitor
    AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Learn More
  38. HDAC8-IN-1

    Catalog No. A17091
    HDAC8 inhibitor
    HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. Learn More
  39. SR-4370

    Catalog No. A16899
    HDAC inhibitor
    SR-?4370 is an HDAC inhibitor. SR-?4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. Learn More
  40. HDAC inhibitor

    Catalog No. A13405
    HDAC inhibitor
  41. UF010

    Catalog No. A15781
    HADC inhibitor
    UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs. Learn More
  42. TMP 195

    Catalog No. A14326
    HDAC inhibitor
    TMP195 is the most potent and selective class IIa HDAC inhibitor. Learn More
  43. 4SC-202

    Catalog No. A14354
    HDAC inhibitor
    4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. Learn More
  44. ST7612AA1

    Catalog No. A14418
    HDAC inhibitor
    ST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity. Learn More
  45. LMK-235

    Catalog No. A14341
    HDAC4/5 inhibitor
    LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. Learn More
  46. Nexturastat A

    Catalog No. A14032
    HDAC6 inhibitor
    Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Learn More
  47. HPOB

    Catalog No. A14197
    HDAC6 inhibitor
    HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM). Learn More
  48. Splitomicin

    Catalog No. A14221
    NAD(+)-dependent histone deacetylase Sir2p inhibitor
    Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay. Learn More
  49. Tasquinimod

    Catalog No. A12616
    HDAC4 inhibitor
    Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Learn More
  50. Santacruzamate A

    Catalog No. A14236
    HDAC inhibitor
    Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. Learn More

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