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| Catalog No. | Inhibitor Name | HDAC | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | HDAC10 | HDAC11 | HD1 | HD2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10979 | Vorinostat | **** | |||||||||||||
| A10611 | Entinostat | ** | * | ||||||||||||
| A10518 | Panobinostat | **** | |||||||||||||
| A10947 | Trichostatin A | **** | |||||||||||||
| A10586 | Mocetinostat | ** | ** | * | * | ||||||||||
| A10122 | Belinostat | *** | |||||||||||||
| A11920 | Romidepsin | *** | *** | ||||||||||||
| A10560 | MC1568 | * | |||||||||||||
| A11042 | Tubastatin A HCl | * | *** | ||||||||||||
| A10488 | Givinostat | **** | **** | ||||||||||||
| A10516 | Dacinostat | *** | |||||||||||||
| A10246 | CUDC-101 | **** | **** | *** | **** | *** | *** | **** | ** | ** | ** | *** | |||
| A10830 | Pracinostat | *** | ** | *** | *** | *** | * | ** | ** | ** | *** | ** | |||
| A11152 | PCI-34051 | * | * | **** | * | ||||||||||
| A10337 | Droxinostat | * | * | * | |||||||||||
| A10700 | Abexinostat | **** | *** | **** | *** | ** | *** | ||||||||
| A13218 | RGFP966 | ** | |||||||||||||
| A11037 | AR-42 | *** | |||||||||||||
| A11940 | Ricolinostat | ** | *** | *** | * | * | **** | * | ** | ||||||
| A11964 | Tacedinaline | * | * | * | ** | ||||||||||
| A11153 | CUDC-907 | **** | **** | **** | ** | * | *** | ** | ** | **** | **** | ||||
| A11355 | M344 | ** | |||||||||||||
| A10954 | Tubacin | **** | |||||||||||||
| A13139 | RG2833 | *** | **** | ||||||||||||
| A12556 | Resminostat | *** | *** | ** | |||||||||||
| A15489 | BRD73954 | * | *** | ** | |||||||||||
| A11361 | BG45 | * | * | ** | |||||||||||
| A14354 | 4SC-202 | * | * | * | |||||||||||
| A16431 | CAY10603 | ** | **** | ||||||||||||
| A14341 | LMK-235 | *** | **** | ||||||||||||
| A14032 | Nexturastat A | **** | |||||||||||||
| A14128 | TMP269 | ** | ** | *** | *** | ||||||||||
| A14197 | HPOB | * | * | * | *** | * | * | ||||||||
| A12722 | Scriptaid | ||||||||||||||
| A12616 | Tasquinimod | ||||||||||||||
| A11042 | Tubastatin A | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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MS-275 (Entinostat)
Catalog No. A10611 HDAC inhibitorMS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More -
Trichostatin-A (TSA)
Catalog No. A10947 HDAC InhibitorTrichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More -
Belinostat (PXD101)
Catalog No. A10122 HDAC inhibitorBelinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Learn More -
LBH589 (Panobinostat)
Catalog No. A10518 HDAC InhibitorLBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM. Learn More -
MC1568
Catalog No. A10560 HDAC InhibitorMC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis. Learn More -
MGCD0103 (Mocetinostat)
Catalog No. A10586 HDAC InhibitorMGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11. Learn More -
Vorinostat (SAHA)
Catalog No. A10979 HDAC inhibitorVorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Learn More -
AR-42 (HDAC-42)
Catalog No. A11037 HDAC inhibitorAR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Learn More -
SB939 ( Pracinostat )
Catalog No. A10830 HDAC inhibitorSB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay. Learn More -
JNJ-26481585 (Quisinostat)
Catalog No. A10492 HDAC inhibitorJNJ-26481585 (Quisinostat) is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L). Learn More -
CUDC-907 (Fimepinostat)
Catalog No. A11153 PI3K/HDAC inhibitorCUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses. Learn More -
Romidepsin (FK228 ,Depsipeptide)
Catalog No. A11920 HDAC inhibitorRomidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively. Learn More -
TMP 269
Catalog No. A14128 HDAC inhibitorTMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Learn More -
RG2833 (RGFP109)
Catalog No. A13139 HDAC inhibitorRG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. Learn More -
Resminostat hydrochloride
Catalog No. A15220 HDAC inhibitorResminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More -
KD 5170
Catalog No. A15354 HDAC inhibitorKD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More -
NCH 51
Catalog No. A15355 HDAC InhibitorNCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM. Learn More -
NSC 3852
Catalog No. A15356 -
TC-H 106
Catalog No. A15357 HDAC inhibitorTC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases). Learn More -
TCS HDAC6 20b
Catalog No. A15387 HDAC6 inhibitorTCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen. Learn More -
R306465
Catalog No. A15437 HDAC inhibitorR306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. Learn More -
Citarinostat (ACY-241)
Catalog No. A12758 HDAC6 inhibitorACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More -
ACY-738
Catalog No. A15934 HDAC6 inhibitorACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. Learn More -
BML-210
Catalog No. A15935 HDAC inhibitorBML-210 is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Learn More -
M344
Catalog No. A11355 HDAC inhibitorM344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation. Learn More -
BG45
Catalog No. A11361 HDAC inhibitorBG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). Learn More -
ITSA-1
Catalog No. A16127 HDAC inhibitorITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. Learn More -
CRA-026440
Catalog No. A12179 -
Valproic acid sodium salt
Catalog No. A10855 HDAC inhibitorValproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Learn More -
JAK/HDAC-IN-1
Catalog No. A13362 JAK2/HDAC dual inhibitorJAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. Learn More -
Sodium phenylbutyrate
Catalog No. A16714 HDAC/ER stress inhibitorSodium phenylbutyrate is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Learn More -
Tubastatin A
Catalog No. A16770 HDAC6 inhibitorTubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Learn More -
CG-200745
Catalog No. A20939 HDAC inhibitorCG-200745 is a potent HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Learn More -
Givinostat
Catalog No. A21126 HDAC inhibitorGivinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More -
HDAC-IN-7
Catalog No. A21252 HDAC1/2/3/10 inhibitorHDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. Learn More -
Givinostat hydrochloride
Catalog No. A21487 HDAC inhibitorGivinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Learn More -
Nanatinostat
Catalog No. A21625 HDAC inhibitorNanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. Learn More -
Belinostat
Catalog No. A21772 HDAC inhibitorBelinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. Learn More -
HDAC-IN-5
Catalog No. A20972 -
Domatinostat tosylate
Catalog No. A20986 HDAC1 inhibitorDomatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Learn More -
J22352
Catalog No. A19174 HDAC6 inhibitorJ22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. Learn More -
BRD 4354
Catalog No. A19532 HDAC5/HDAC9 inhibitorBRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. Learn More -
FT895
Catalog No. A19615 HDAC11 inhibitorFT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM. Learn More -
ACY-957
Catalog No. A19666 HDAC1 /HDAC2 inhibitorACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. Learn More -
TH34
Catalog No. A19873 HDAC6/8/10 inhibitorTH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3. Learn More -
ACY-1083
Catalog No. A19985 HDAC6 inhibitorACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. Learn More -
RTS-V5
Catalog No. A20099 HDAC/proteasome inhibitorRTS-V5 is a dual HDAC/proteasome inhibitor with IC50s of 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. Learn More -
Tefinostat
Catalog No. A20258 pan HDAC inhibitorTefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity. Learn More -
Oxamflatin
Catalog No. A20265 HDAC inhibitorOxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM. Learn More -
WT-161
Catalog No. A20432 HDAC6 inhibitorWT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM. Learn More
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