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| Catalog No. | Inhibitor Name | HDAC | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | HDAC10 | HDAC11 | HD1 | HD2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A10979 | Vorinostat | **** | |||||||||||||
| A10611 | Entinostat | ** | * | ||||||||||||
| A10518 | Panobinostat | **** | |||||||||||||
| A10947 | Trichostatin A | **** | |||||||||||||
| A10586 | Mocetinostat | ** | ** | * | * | ||||||||||
| A10122 | Belinostat | *** | |||||||||||||
| A11920 | Romidepsin | *** | *** | ||||||||||||
| A10560 | MC1568 | * | |||||||||||||
| A11042 | Tubastatin A HCl | * | *** | ||||||||||||
| A10488 | Givinostat | **** | **** | ||||||||||||
| A10516 | Dacinostat | *** | |||||||||||||
| A10246 | CUDC-101 | **** | **** | *** | **** | *** | *** | **** | ** | ** | ** | *** | |||
| A10830 | Pracinostat | *** | ** | *** | *** | *** | * | ** | ** | ** | *** | ** | |||
| A11152 | PCI-34051 | * | * | **** | * | ||||||||||
| A10337 | Droxinostat | * | * | * | |||||||||||
| A10700 | Abexinostat | **** | *** | **** | *** | ** | *** | ||||||||
| A13218 | RGFP966 | ** | |||||||||||||
| A11037 | AR-42 | *** | |||||||||||||
| A11940 | Ricolinostat | ** | *** | *** | * | * | **** | * | ** | ||||||
| A11964 | Tacedinaline | * | * | * | ** | ||||||||||
| A11153 | CUDC-907 | **** | **** | **** | ** | * | *** | ** | ** | **** | **** | ||||
| A11355 | M344 | ** | |||||||||||||
| A10954 | Tubacin | **** | |||||||||||||
| A13139 | RG2833 | *** | **** | ||||||||||||
| A12556 | Resminostat | *** | *** | ** | |||||||||||
| A15489 | BRD73954 | * | *** | ** | |||||||||||
| A11361 | BG45 | * | * | ** | |||||||||||
| A14354 | 4SC-202 | * | * | * | |||||||||||
| A16431 | CAY10603 | ** | **** | ||||||||||||
| A14341 | LMK-235 | *** | **** | ||||||||||||
| A14032 | Nexturastat A | **** | |||||||||||||
| A14128 | TMP269 | ** | ** | *** | *** | ||||||||||
| A14197 | HPOB | * | * | * | *** | * | * | ||||||||
| A12722 | Scriptaid | ||||||||||||||
| A12616 | Tasquinimod | ||||||||||||||
| A11042 | Tubastatin A | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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TMP 269
Catalog No. A14128 HDAC inhibitorTMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Learn More -
ITSA-1
Catalog No. A16127 HDAC inhibitorITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. Learn More -
BG45
Catalog No. A11361 HDAC inhibitorBG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). Learn More -
M344
Catalog No. A11355 HDAC inhibitorM344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation. Learn More -
BML-210
Catalog No. A15935 HDAC inhibitorBML-210 is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Learn More -
ACY-738
Catalog No. A15934 HDAC6 inhibitorACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. Learn More -
R306465
Catalog No. A15437 HDAC inhibitorR306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. Learn More -
TCS HDAC6 20b
Catalog No. A15387 HDAC6 inhibitorTCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen. Learn More -
TC-H 106
Catalog No. A15357 HDAC inhibitorTC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases). Learn More -
NSC 3852
Catalog No. A15356 -
NCH 51
Catalog No. A15355 HDAC InhibitorNCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM. Learn More -
KD 5170
Catalog No. A15354 HDAC inhibitorKD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More -
Resminostat hydrochloride
Catalog No. A15220 HDAC inhibitorResminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More -
RG2833 (RGFP109)
Catalog No. A13139 HDAC inhibitorRG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. Learn More -
BRD73954
Catalog No. A15489 HDAC inhibitorBRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively). Learn More -
UF010
Catalog No. A15781 HADC inhibitorUF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs. Learn More -
ACY-241
Catalog No. A12758 HDAC6 inhibitorACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More -
CAY10603
Catalog No. A16431 HDAC6 inhibitorCAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs. Learn More -
TMP 195
Catalog No. A14326 HDAC inhibitorTMP195 is the most potent and selective class IIa HDAC inhibitor. Learn More -
4SC-202
Catalog No. A14354 HDAC inhibitor4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. Learn More -
ST7612AA1
Catalog No. A14418 HDAC inhibitorST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity. Learn More -
LMK-235
Catalog No. A14341 HDAC4/5 inhibitorLMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. Learn More -
Santacruzamate A
Catalog No. A14236 HDAC inhibitorSantacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. Learn More -
Tasquinimod
Catalog No. A12616 HDAC4 inhibitorTasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Learn More -
Splitomicin
Catalog No. A14221 NAD(+)-dependent histone deacetylase Sir2p inhibitorSplitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay. Learn More -
HPOB
Catalog No. A14197 HDAC6 inhibitorHPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM). Learn More -
SR-4370
Catalog No. A16899 HDAC inhibitorSR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. Learn More -
HDAC8-IN-1
Catalog No. A17091 HDAC8 inhibitorHDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. Learn More -
Tinostamustine (EDO-S101)
Catalog No. A18342 HDAC inhibitorEDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. Learn More -
ACY-775
Catalog No. A12456 HDAC6 inhibitorACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5?nM. Learn More -
CHDI-390576
Catalog No. A18899 HDAC inhibitorCHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. Learn More -
SW-100
Catalog No. A18947 HDAC6 inhibitorSW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. Learn More -
SS-208
Catalog No. A18952 HDAC6 inhibitorSS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma. Learn More -
MPT0E028
Catalog No. A18982 HDAC inhibitorMPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Learn More -
AES-135
Catalog No. A19087 HDAC inhibitorAES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity. Learn More -
Ac-Lys-AMC
Catalog No. A18461 fluorescent substrate for HDACAc-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs. Learn More -
SIS-17
Catalog No. A18463 HDAC 11 inhibitorSIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Learn More -
CM-675
Catalog No. A18741 PDE5/HDAC-1 inhibitorCM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More -
Tucidinostat (Chidamide)
Catalog No. A17861 HDAC inhibitorTucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. Learn More -
Valproic acid
Catalog No. A17323 HDAC inhibitorValproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Learn More -
SKLB-23bb
Catalog No. A18339 HDAC6 inhibitorSKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. Learn More -
Remetinostat
Catalog No. A12149 HDAC inhibitorRemetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. Learn More -
Nexturastat A
Catalog No. A14032 HDAC6 inhibitorNexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Learn More -
Scriptaid
Catalog No. A12722 -
Tubastatin A HCl
Catalog No. A11042 HDAC6 inhibitorTubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Learn More -
PCI-24781 (Abexinostat)
Catalog No. A10700 HDAC InhibitorPCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor. Learn More -
AR-42 (HDAC-42)
Catalog No. A11037 HDAC inhibitorAR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Learn More -
Droxinostat
Catalog No. A10337 HDAC inhibitorDroxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively. Learn More -
ITF2357 (Givinostat)
Catalog No. A10488 HDAC inhibitorITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Learn More
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