HDAC

Catalog No.Inhibitor Name HDAC HDAC1 HDAC2 HDAC3 HDAC4HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2
A10979Vorinostat
****
A10611Entinostat
**
*
A10518Panobinostat
****
A10947Trichostatin A
****
A10586Mocetinostat
**
**
*
*
A10122Belinostat
***
A11920Romidepsin
***
***
A10560MC1568
*
A11042Tubastatin A HCl
*
***
A10488Givinostat
****
****
A10516Dacinostat
***
A10246CUDC-101
****
****
***
****
***
***
****
**
**
**
***
A10830Pracinostat
***
**
***
***
***
*
**
**
**
***
**
A11152PCI-34051
*
*
****
*
A10337Droxinostat
*
*
*
A10700Abexinostat
****
***
****
***
**
***
A13218RGFP966
**
A11037AR-42
***
A11940Ricolinostat
**
***
***
*
*
****
*
**
A11964Tacedinaline
*
*
*
**
A11153CUDC-907
****
****
****
**
*
***
**
**
****
****
A11355M344
**
A10954Tubacin
****
A13139RG2833
***
****
A12556Resminostat
***
***
**
A15489BRD73954
*
***
**
A11361BG45
*
*
**
A143544SC-202
*
*
*
A16431CAY10603
**
****
A14341LMK-235
***
****
A14032Nexturastat A
****
A14128TMP269
**
**
***
***
A14197HPOB
*
*
*
***
*
*
A12722Scriptaid
A12616Tasquinimod
A11042Tubastatin A
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. TMP 269

    Catalog No. A14128
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    HDAC inhibitor
    TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Learn More
  2. ITSA-1

    Catalog No. A16127
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    HDAC inhibitor
    ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. Learn More
  3. BG45

    Catalog No. A11361
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    HDAC inhibitor
    BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively). Learn More
  4. M344

    Catalog No. A11355
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    HDAC inhibitor
    M344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation. Learn More
  5. BML-210

    Catalog No. A15935
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    HDAC inhibitor‎
    BML-210 is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Learn More
  6. ACY-738

    Catalog No. A15934
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    HDAC6 inhibitor
    ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. Learn More
  7. R306465

    Catalog No. A15437
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    HDAC inhibitor
    R306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models. Learn More
  8. TCS HDAC6 20b

    Catalog No. A15387
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    HDAC6 inhibitor
    TCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen. Learn More
  9. TC-H 106

    Catalog No. A15357
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    HDAC inhibitor
    TC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases). Learn More
  10. NSC 3852

    Catalog No. A15356
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    HDAC Inhibitor
    NSC 3852 is an HDAC (histone deacetylase) inhibitor. Learn More
  11. NCH 51

    Catalog No. A15355
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    HDAC Inhibitor
    NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM. Learn More
  12. KD 5170

    Catalog No. A15354
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    HDAC inhibitor
    KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. Learn More
  13. Resminostat hydrochloride

    Catalog No. A15220
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    HDAC inhibitor
    Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM. Learn More
  14. RG2833 (RGFP109)

    Catalog No. A13139
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    HDAC inhibitor
    RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3. Learn More
  15. BRD73954

    Catalog No. A15489
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    HDAC inhibitor
    BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively). Learn More
  16. UF010

    Catalog No. A15781
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    HADC inhibitor
    UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs. Learn More
  17. ACY-241

    Catalog No. A12758
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    HDAC6 inhibitor
    ACY-241 is a new, selective and orally available inhibitor of HDAC6. Learn More
  18. HDAC inhibitor

    Catalog No. A13405
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    HDAC inhibitor
  19. CAY10603

    Catalog No. A16431
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    HDAC6 inhibitor
    CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs. Learn More
  20. TMP 195

    Catalog No. A14326
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    HDAC inhibitor
    TMP195 is the most potent and selective class IIa HDAC inhibitor. Learn More
  21. 4SC-202

    Catalog No. A14354
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    HDAC inhibitor
    4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. Learn More
  22. ST7612AA1

    Catalog No. A14418
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    HDAC inhibitor
    ST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity. Learn More
  23. LMK-235

    Catalog No. A14341
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    HDAC4/5 inhibitor
    LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor. Learn More
  24. Santacruzamate A

    Catalog No. A14236
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    HDAC inhibitor
    Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. Learn More
  25. Tasquinimod

    Catalog No. A12616
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    HDAC4 inhibitor
    Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling. Learn More
  26. Splitomicin

    Catalog No. A14221
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    NAD(+)-dependent histone deacetylase Sir2p inhibitor
    Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay. Learn More
  27. HPOB

    Catalog No. A14197
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    HDAC6 inhibitor
    HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM). Learn More
  28. SR-4370

    Catalog No. A16899
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    HDAC inhibitor
    SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. Learn More
  29. HDAC8-IN-1

    Catalog No. A17091
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    HDAC8 inhibitor
    HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. Learn More
  30. Tinostamustine (EDO-S101)

    Catalog No. A18342
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    HDAC inhibitor
    EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. Learn More
  31. ACY-775

    Catalog No. A12456
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    HDAC6 inhibitor
    ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5?nM. Learn More
  32. CHDI-390576

    Catalog No. A18899
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    HDAC inhibitor
    CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. Learn More
  33. SW-100

    Catalog No. A18947
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    HDAC6 inhibitor
    SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. Learn More
  34. SS-208

    Catalog No. A18952
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    HDAC6 inhibitor
    SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma. Learn More
  35. MPT0E028

    Catalog No. A18982
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    HDAC inhibitor
    MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Learn More
  36. AES-135

    Catalog No. A19087
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    HDAC inhibitor
    AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity. Learn More
  37. Ac-Lys-AMC

    Catalog No. A18461
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    fluorescent substrate for HDAC
    Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs. Learn More
  38. SIS-17

    Catalog No. A18463
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    HDAC 11 inhibitor
    SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Learn More
  39. CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. Learn More
  40. Tucidinostat (Chidamide)

    Catalog No. A17861
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    HDAC inhibitor
    Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. Learn More
  41. Valproic acid

    Catalog No. A17323
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    HDAC inhibitor
    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Learn More
  42. SKLB-23bb

    Catalog No. A18339
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    HDAC6 inhibitor
    SKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. Learn More
  43. Remetinostat

    Catalog No. A12149
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    HDAC inhibitor
    Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. Learn More
  44. Nexturastat A

    Catalog No. A14032
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    HDAC6 inhibitor
    Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Learn More
  45. Scriptaid

    Catalog No. A12722
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    HDAC inhibitor
    Scriptaid is an HDAC inhibitor (histone deacetylase). Learn More
  46. Tubastatin A HCl

    Catalog No. A11042
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    HDAC6 inhibitor
    Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Learn More
  47. PCI-24781 (Abexinostat)

    Catalog No. A10700
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    HDAC Inhibitor
    PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor. Learn More
  48. AR-42 (HDAC-42)

    Catalog No. A11037
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    HDAC inhibitor
    AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Learn More
  49. Droxinostat

    Catalog No. A10337
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    HDAC inhibitor
    Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively. Learn More
  50. ITF2357 (Givinostat)

    Catalog No. A10488
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    HDAC inhibitor
    ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Learn More

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