PDGFR
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A11350 CP-673451
CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM. -
A11052 Crenolanib (CP-868569)
Crenolanib (CP-868569) is an orally bioavailable, selective small molecule inhibitor of the PDGFR tyrosine kinase, inhibiting both PDGFRA and PDGFRB at picomolar concentrations. -
A10504 KRN 633
KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM).
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A11753 MK-2461
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. -
A10880 Sunitinib Malate
Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). -
A10903 Telatinib (BAY 57-9352)
Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases.







