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Apoptosis

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Items 1-50 of 249

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  1. A10022
    ABT-263 (Navitoclax)

    Bcl-2 inhibitor

    ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
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  2. A10057
    Aloe-emodin

    Aloe emodin is a anthraquinone present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action.

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  3. A10250
    Regorafenib (BAY 73-4506)

    VEGFR inhibitor

    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.
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  4. A10255
    ABT-737

    Bcl-2 Inhibitor

    ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
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  5. A10398
    Flunisolide

    Flunisolide is a corticosteroid often used to treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.
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  6. A10401
    Flurbiprofen

    nonsteroidal anti-inflammatory agent

    Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
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  7. A10491
    JNJ 26854165

    p53 activator

    JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias.
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  8. A10522
    Lenalidomide (CC-5013)

    Ubiquitin ligase inducer

    Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.
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  9. A10585
    Metronidazole

    nitroimidazole antibiotic medication

    Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.
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  10. A10657
    Nutlin-3

    Mdm2 antagonist

    MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.
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  11. A10665
    Obatoclax mesylate (GX15-070)

    Bcl-2 Inhibitor

    Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
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  12. A10715
    Danusertib (PHA-739358)

    Aurora inhibitor

    Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
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  13. A10743
    Pomalidomide (CC-4047)

    TNF-alpha inhibitor

    Pomalidomide is a derivative of thalidomide and acts as an immunomodulator.
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  14. A10924
    Thalidomide

    E3 ubiquitin ligase inhibitor

    Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.
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  15. A10955
    TW-37

    Bcl-2 inhibitor

    TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
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  16. A10984
    VX-765 (Belnacasan)

    Caspase-1/4 inhibitor

    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
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  17. A11002
    YM155 (Sepantronium Bromide)

    Survivin Inhibitor

    YM155 is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity.
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  18. A11090
    PAC-1

    Caspase activator

    PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
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  19. A11179
    NSC-207895 (XI-006)

    MDMX Inhibitor

    NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

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  20. A11180
    TG101209

    JAK2 inhibitor

    TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

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  21. A11212
    EP1013

    caspase inhibitor

    EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
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  22. A11356
    BOC-D-FMK

    caspase inhibitor

    Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M.
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  23. A11394
    Emricasan

    Caspase inhibitor

    Emricasan is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases.
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  24. A11448
    HA14-1

    Bcl-2 inhibitor

    HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2.
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  25. A11501
    Nutlin 3a

    MDM2 inhibitor

    Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
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  26. A11502
    Nutlin 3b

    MDM2 inhibitor

    Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
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  27. A11630
    Geniposidic acid

    anticancer and radioprotection agent

    Geniposidic acid is an effective anticancer and radioprotection agent.
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  28. A11928
    LCL-161

    Antagonist of IAPs inhibitor

    LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity.
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  29. A11931
    RITA (NSC 652287)

    p53 activator

    RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
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  30. A11943
    Tenovin-1

    p53 activator

    Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation.
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  31. A11944
    Apoptosis Activator 2

    Apoptosis Activator

    Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells
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  32. A11973
    Necrostatin-1

    RIPK1 inhibitor

    Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).
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  33. A11974
    GW 4869

    N-SMase inhibitor

    GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

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  34. A11980
    TPEN (TPEDA)

    TPEN is a heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+.
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  35. A11988
    Gambogic acid

    Bcl-2 inhibitor

    Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
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  36. A12002
    Arctigenin

    Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM)
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  37. A12080
    Jaceosidin

    Jaceosidin is a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells.
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  38. A12197
    KR-33493

    FAF1 inhibitor

    KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
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  39. A12267
    Clofilium tosylate

    Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent.
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  40. A12284
    Kinetin riboside

    PINK1 activator

    Kinetin riboside is an activator of the Parkinson's Disease-associated PTEN-induced Putative Kinase 1 (PINK1), and acts independently from mitochondrial depolarization.
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  41. A12286
    SID 3712249

    miR-544 inhibitor

    SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544).
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  42. A12305
    Tenovin-6

    p53 activator

    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
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  43. A12313
    C 87

    TNFα inhibitor

    C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.
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  44. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  45. A12416
    CID 2011756

    PKD inhibitor

    CID 2011756 is a protein kinase D (PKD) inhibitor (IC50 values are 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively).
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  46. A12423
    kb NB 142-70

    PKD inhibitor

    kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).
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  47. A12449
    Pifithrin-u

    p53 inhibitor

    inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL.
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  48. A12450
    Pifithrin-beta

    p53 Inhibitor

    Pifithrin-beta is a small molecule inhibitor of p53.
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  49. A12451
    Pifithrin-alpha

    p53 inhibitor

    Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.
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  50. A12473
    RIPA-56

    RIP1 inhibitor

    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.
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