Raf

Catalog No.Inhibitor Name RafC-Raf/Raf-1B-RafA-rafOther
A10739Vemurafenib
*
**
SRMS,ACK1,MAP4K5 (KHS1)
A10002PLX-4720
***
***
BRK,FRK,CSK
A11381Dabrafenib
****
****
A10420GDC-0879
****
A10773RAF265
**
VEGFR2
A11063AZ 628
**
**
A10661NVP-BHG712
*
EphB4,c-Src,c-Abl
A10829SB590885
****
A11077ZM 336372
*
A10001Sorafenib
****
**
mVEGFR2(Flk1),mVEGFR3,mPDGFRβ
A11436GW5074
***
A13323TAK-632
****
***
Aurora B,PDGFRβ,FGFR3
A13772CEP-32496
**
***
RET,PDGFRβ,LCK
A13226Encorafenib
****
A14019RO5126766
*
***
MEK1
A15855PLX7904
A11240MLN2480
A10250Regorafenib (BAY 73-4506)
****
**
FGFR1, Kit, PDGFRβ, RET, Tie-2 , VEGFR1, VEGFR2, VEGFR3
A11211ML 786 dihydrochloride
****
****
Abl-1, DDR2, EPHA2, RET, PERK
A12739PF-04880594
****
****
A13525L-779450
****
p38α, GSK3β, Lck

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. B-Raf inhibitor 1 dihydrochloride

    Catalog No. A21834
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    Raf kinase inhibitor
    B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. Learn More
  2. TAK-632

    Catalog No. A13323
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    pan-RAF inhibitor
    TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio. Learn More
  3. RO5126766 (CH5126766)

    Catalog No. A14019
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    Raf/MEK dual inhibitor
    RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Learn More
  4. B-Raf-inhibitor 1

    Catalog No. A14122
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    B-Raf inhibitor
    B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively Learn More
  5. CEP-32496 hydrochloride

    Catalog No. A15040
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    Raf Inhibitor
    CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM, respectively. Learn More
  6. Dabrafenib Mesylate

    Catalog No. A15059
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    Raf inhibitor
    Dabrafenib Mesylate is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively. Learn More
  7. PLX7904

    Catalog No. A15855
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    Raf inhibitor
    PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. Learn More
  8. ML 786 dihydrochloride

    Catalog No. A11211
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    Raf inhibitor
    ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively). Learn More
  9. HG6-64-1

    Catalog No. A16022
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    B-Raf inhibitor
    HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738. Learn More
  10. Lifirafenib

    Catalog No. A20988
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    Raf/EGFR inhibitor
    Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. Learn More
  11. LUT014

    Catalog No. A19449
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    B-Raf inhibitor
    LUT014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated EGFR Inhibitors treatment. Extracted from patent WO 2019026065A2 . Learn More
  12. ERK-IN-1

    Catalog No. A19080
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    RAF/ERK1/2 inhibitor
    ERK-IN-1 (compound B) is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. Learn More
  13. RAF mutant-IN-1

    Catalog No. A19011
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    Raf nhibitor
    RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF340D/Y341D, B-RAFV600E and B-RAFWT, respectively. Learn More
  14. Regorafenib Hydrochloride

    Catalog No. A11546
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    VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
    Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. Learn More
  15. LY3009120

    Catalog No. A16603
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    pan RAF inhibitor
    LY3009120 is a pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT with IC50s of 5.8, 9.1 and 15 nM, respectively. Learn More
  16. B-Raf IN 1

    Catalog No. A21055
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    B-Raf kinase inhibitor
    B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. Learn More
  17. Balamapimod (MKI-833)

    Catalog No. A13119
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    Ras/Raf/MEK inhibitor
    Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor. Learn More
  18. LGX 818 (Encorafenib)

    Catalog No. A13226
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    Selective B-RAF Inhibitor
    LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity. Learn More
  19. Belvarafenib

    Catalog No. A13177
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    pan RAF inhibitor
    Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. Learn More
  20. RAF709

    Catalog No. A16842
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    raf kinase inhibitor
    RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM. Learn More
  21. SB590885

    Catalog No. A10829
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    B-Raf Inhibitor
    SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively. Learn More
    • New

    AZ304

    Catalog No. A17225
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    dual BRAF inhibitor
    AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively. Learn More
  22. AZ628

    Catalog No. A11063
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    Raf inhibitor
    AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF. Learn More
  23. RAF265 (CHIR-265)

    Catalog No. A10773
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    RAF/VEGFR Inhibitor
    RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers. Learn More
  24. GDC-0879

    Catalog No. A10420
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    B-Raf inhibitor
    GDC-0879 is a specific inhibitor of B-Raf kinase enzyme,targeting B-Raf (V600E) (IC50: 0.13 nM). Learn More
  25. PLX4032 (Vemurafenib)

    Catalog No. A10739
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    Raf inhibitor
    PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM. Learn More
  26. PLX-4720

    Catalog No. A10002
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    Raf inhibitor
    PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf. Learn More
  27. Sorafenib Tosylate (Nexavar)

    Catalog No. A10001
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    Raf inhibitor
    Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Learn More
  28. Regorafenib (BAY 73-4506)

    Catalog No. A10250
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    VEGFR inhibitor
    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More
  29. LXH254

    Catalog No. A16841
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    pan-RAF inhibitor
    LXH254 is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays. Learn More
  30. Locostatin

    Catalog No. A16079
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    RKIP/Raf1 inhibitor
    Locostatin is a cell permeable, potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration. Learn More
  31. ZM 336372

    Catalog No. A11077
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    C-Raf inhibitor
    ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Learn More
  32. Diazepinomicin

    Catalog No. A12891
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    RAS/RAF/MAPK inhibitor
    Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Learn More
  33. L-779450

    Catalog No. A13525
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    Raf inhibitor
    L-779450 is a raf kinase inhibitor, a potential treatment for neurotraumatic diseases. Learn More
  34. PF-04880594

    Catalog No. A12739
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    RAF inhibitor
    PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively. Learn More
  35. BRAF inhibitor

    Catalog No. A11333
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    BRAF inhibitor
    BRAF inhibitor is a potent BRAF inhibitor. Learn More
  36. MLN2480 (BIIB-024)

    Catalog No. A11240
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    pan-Raf inhibitor
    MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials. Learn More
  37. CEP-32496

    Catalog No. A13772
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    Raf inhibitor
    CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. Learn More
  38. GW 5074

    Catalog No. A11436
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    Raf-1 Inhibitor
    GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor Learn More
  39. Dabrafenib (GSK2118436A)

    Catalog No. A11381
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    Raf inhibitor
    Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial. Learn More
  40. Regorafenib monohydrate

    Catalog No. A15218
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    Tyrosine kinase inhibitor
    Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Learn More
  41. Raf265 derivative

    Catalog No. A10774
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    RAF/VEGFR Inhibitor
    Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. Learn More
  42. NVP-BHG712

    Catalog No. A10661
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    EphB4 inhibitor
    NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Learn More
  43. Lifirafenib (BGB-283)

    Catalog No. A16844
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    BRAF inhibitor
    Lifirafenib (BGB-283), also known as Beigene-283, potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant. Learn More

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