mTOR

Catalog No.Inhibitor Name mTOR mTORC1 mTORC2 Other Targets
A10133Dactolisib
***
p110α,p110γ,p110δ
A10782Rapamycin
****
A10374Everolimus
***
A10114AZD8055
****
DNA-PK,PI3Kδ,PI3Kα
A10906Temsirolimus
*
A10726PI-103
*
p110α,p110δ,p110β
A10505KU-0063794
**
**
A10746Torkinib
**
p110δ,PDGFR,DNA-PK
A10295Ridaforolimus
****
A11461INK 128
****
PI3Kα,PI3Kγ,PI3Kδ
A10997Voxtalisib Analogue
*
PI3Kγ,PI3Kα,PI3Kδ
A11587Torin 1
***
***
**
DNA-PK,p110γ,C2α
A11035Omipalisib
****
****
p110α,p110δ,p110γ
A11056OSI-027
***
*
*
PI3Kγ,DNA-PK,PI3Kα
A11024PF-04691502
**
PI3Kδ,PI3Kα,PI3Kγ
A11023Apitolisib
*
p110α,p110δ,p110γ
A10438GSK1059615
**
PI3Kα,PI3Kβ,PI3Kδ
A11079Gedatolisib
****
PI3Kα,PI3Kγ
A10989WYE-354
***
PI3Kα,PI3Kγ
A11303Vistusertib
***
P-Akt (S473),pS6 (S235/236)
A11586Torin 2
****
ATM,ATR,DNA-PK
A11038WYE-125132
****
A11207PP121
**
PDGFR,Hck,VEGFR
A11187WYE-687
***
PI3Kα,PI3Kγ,p38α
A11169CH5132799
*
PI3Kα,PI3Kγ,PI3Kβ
A11188WAY-600
**
PI3Kα,PI3Kγ
A13328ETP-46464
****
ATR,DNA-PK,PI3Kα
A11443GDC-0349
***
PI3Kα
A12395XL388
**
**
*
CYP2C9,CYP3A4
A13078CC-223
**
cFMS,FLT4,DNA-PK
A16276Voxtalisib
*
PI3Kγ,PI3Kα,PI3Kδ
A11950Zotarolimus
***
A10389Tacrolimus
A11162BGT226
PI3Kα,PI3Kγ,PI3Kβ
A10693Palomid 529
A10210Chrysophanic Acid
EGFR
A11537QL-IX-55
A12480VS-5584
****
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A12704SF1126
PI3K
A12935PF-04979064
****
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ, Akt
A14432GNE-493
***
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A15175mTOR inhibitor (mTOR-IN-1)
***
A15508MHY1485
A16126LY3023414
PI3Kα, Akt1, DNA-PK

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. QL-IX-55

    Catalog No. A11537
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    mTORC1/2 inhibitor
    QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively. Learn More
  2. WYE-354

    Catalog No. A10989
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    mTOR Inhibitor
    WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases. Learn More
  3. FK-506 (Tacrolimus)

    Catalog No. A10389
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    mTOR inhibitor
    FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells. Learn More
  4. AZD2014 (Vistusertib)

    Catalog No. A11303
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    mTORC1/2 inhibitor
    AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor. Learn More
  5. Torin 2

    Catalog No. A11586
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    mTOR inhibitor
    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Learn More
  6. AZD8055

    Catalog No. A10114
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    mTOR Inhibitor
    AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. Learn More
  7. VS-5584

    Catalog No. A12480
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    PI3K/mTOR inhibitor
    VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  8. mTOR inhibitor (mTOR-IN-1)

    Catalog No. A15175
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    mTOR inhibitor
    mTOR inhibitor is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 1.5 nM. Learn More
  9. MHY1485

    Catalog No. A15508
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    mTOR inhibitor
    MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes. Learn More
  10. Torin 1

    Catalog No. A11587
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    mTOR inhibitor
    Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM. Learn More
  11. LY3023414

    Catalog No. A16126
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    PI3K/mTOR Dual Inhibitor
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). Learn More
  12. SAR245409 (XL765, Voxtalisib)

    Catalog No. A16276
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    PI3K/mTOR dual inhibitor
    SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Learn More
  13. FT-1518

    Catalog No. A19230
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    mTORC1/mTORC2 inhibitor
    FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. Learn More
  14. PI3K/mTOR Inhibitor-2

    Catalog No. A19621
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    dual pan-PI3K/mTOR inhibitor
    PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity. Learn More
  15. mTOR inhibitor-1

    Catalog No. A20029
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    mTOR inhibitor
    mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. Learn More
  16. PI3K/mTOR Inhibitor-1

    Catalog No. A20055
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    PI3K/mTOR inhibitor
    PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual PI3K/mTOR inhibitor with IC50s of 20/376/204/46 nM and 186 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ and mTOR, respectively. Antitumor activity. Learn More
  17. PQR620

    Catalog No. A20400
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    mTORC1/2 inhibitor
    PQR620 is a novel potent and selective brain penetrant inhibitor of mTORC1/2. Learn More
  18. 3BDO

    Catalog No. A22360
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    mTOR activator
    3BDO is a new mTOR activator which can also inhibit autophagy. Learn More
  19. BEZ235 (NVP-BEZ235, Dactolisib)

    Catalog No. A10133
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    PI3K/mTOR Inhibitor
    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More
  20. PP242 (Torkinib)

    Catalog No. A10746
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    mTOR Inhibitor
    PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2. Learn More
  21. PF-04691502

    Catalog No. A11024
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    PI3K/mTOR Inhibitor
    PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway. Learn More
  22. GDC-0980 (Apitolisib, RG7422)

    Catalog No. A11023
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    mTOR/PI3K Inhibitor
    GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively. Learn More
  23. GSK2126458 (Omipalisib)

    Catalog No. A11035
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    mTOR/PI3K Inhibitor,
    GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models. Learn More
  24. Everolimus (RAD001)

    Catalog No. A10374
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    mTOR inhibitor
    Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor. Learn More
  25. GSK1059615

    Catalog No. A10438
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    mTOR/PI3K Inhibitor
    GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM). Learn More
  26. PI-103

    Catalog No. A10726
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    PI3K Inhibitor
    PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Learn More
  27. Rapamycin (Sirolimus)

    Catalog No. A10782
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    mTOR Inhibitors
    Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2). Learn More
  28. PQR-530

    Catalog No. A19209
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    dual pan-PI3K/mTORC1/2 inhibitor
    PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. Learn More
  29. 42-(2-Tetrazolyl)rapamycin

    Catalog No. A21394
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    mTOR inhibitor
    42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor. Learn More
  30. HDACs/mTOR Inhibitor 1

    Catalog No. A13462
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    HDACs/mTOR Inhibitor 1
    HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies. Learn More
  31. mTOR inhibitor-2

    Catalog No. A13035
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    mTOR inhibitor
    mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates. Learn More
  32. Dactolisib Tosylate

    Catalog No. A11327
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    dual PI3K and mTOR kinase inhibitor
    Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2. Learn More
  33. CZ415

    Catalog No. A16476
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    mTOR inhibitor
    CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex. Learn More
  34. Desmethyl-VS-5584

    Catalog No. A10900
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    PI3K/mTOR inhibitor
    Desmethyl-VS-5584 is a demethyl analogue of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  35. KU-0063794

    Catalog No. A10505
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    mTOR Inhibitor
    KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively). Learn More
  36. Temsirolimus (Torisel)

    Catalog No. A10906
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    mTOR inhibitor
    Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Learn More
  37. NSC781406

    Catalog No. A20402
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    PI3K/mTOR inhibitor
    NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα. Learn More
  38. CC-223

    Catalog No. A13078
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    mTOR Inhibitor
    CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM). Learn More
  39. CC-115

    Catalog No. A15779
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    mTOR/DNA-PK inhibitor
    CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). Learn More
  40. Palomid 529 (P529)

    Catalog No. A10693
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    AKT Inhibitor
    Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation. Learn More
  41. Zotarolimus

    Catalog No. A11950
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    mTOR inhibitor
    Zotarolimus is an immunosuppressant. It is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Learn More
  42. WYE-687

    Catalog No. A11187
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    mTOR Inhibitor

    WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin(mTOR).

    Learn More
  43. WAY-600

    Catalog No. A11188
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    mTOR inhibitor

    WAY-600 is a single digit nanomolar inhibitor of the mTOR kinases, with significant selectivity for these enzymes over phosphatidylinositol 3-kinase (PI3K) isofoms (>100-fold).

    Learn More
  44. PP121

    Catalog No. A11207
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    PI3K Inhibitor
    PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More
  45. NVP-BGT226

    Catalog No. A11162
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    PI3K inhibitor

    NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.

    Learn More
  46. Deforolimus (Ridaforolimus)

    Catalog No. A10295
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    mTOR Inhibitor

    Deforolimus (Ridaforolimus) is an investigational targeted and small-molecule inhibitor of the protein mTOR. Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis.

    Learn More
  47. PKI-587 ( Gedatolisib )

    Catalog No. A11079
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    PI3K/mTOR inhibitor
    PKI-587 is a highly potent PI3K/mTOR kinase inhibitor that inhibits PI3K-α,β,γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively. Learn More
  48. OSI-027

    Catalog No. A11056
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    mTOR inhibitor
    OSI-027 is a potent, selective and orally bioavailable mTOR kinase inhibitor that inhibits the kinase activity associated with both the TORC1 and TORC2 complexes of mTOR. Learn More
  49. INK 128 (MLN0128)

    Catalog No. A11461
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    mTOR inhibitor
    INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Learn More
  50. GDC-0349

    Catalog No. A11443
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    mTOR inhibitor
    GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Learn More

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