mTOR

Catalog No.Inhibitor Name mTOR mTORC1 mTORC2 Other Targets
A10133Dactolisib
***
p110α,p110γ,p110δ
A10782Rapamycin
****
A10374Everolimus
***
A10114AZD8055
****
DNA-PK,PI3Kδ,PI3Kα
A10906Temsirolimus
*
A10726PI-103
*
p110α,p110δ,p110β
A10505KU-0063794
**
**
A10746Torkinib
**
p110δ,PDGFR,DNA-PK
A10295Ridaforolimus
****
A11461INK 128
****
PI3Kα,PI3Kγ,PI3Kδ
A10997Voxtalisib Analogue
*
PI3Kγ,PI3Kα,PI3Kδ
A11587Torin 1
***
***
**
DNA-PK,p110γ,C2α
A11035Omipalisib
****
****
p110α,p110δ,p110γ
A11056OSI-027
***
*
*
PI3Kγ,DNA-PK,PI3Kα
A11024PF-04691502
**
PI3Kδ,PI3Kα,PI3Kγ
A11023Apitolisib
*
p110α,p110δ,p110γ
A10438GSK1059615
**
PI3Kα,PI3Kβ,PI3Kδ
A11079Gedatolisib
****
PI3Kα,PI3Kγ
A10989WYE-354
***
PI3Kα,PI3Kγ
A11303Vistusertib
***
P-Akt (S473),pS6 (S235/236)
A11586Torin 2
****
ATM,ATR,DNA-PK
A11038WYE-125132
****
A11207PP121
**
PDGFR,Hck,VEGFR
A11187WYE-687
***
PI3Kα,PI3Kγ,p38α
A11169CH5132799
*
PI3Kα,PI3Kγ,PI3Kβ
A11188WAY-600
**
PI3Kα,PI3Kγ
A13328ETP-46464
****
ATR,DNA-PK,PI3Kα
A11443GDC-0349
***
PI3Kα
A12395XL388
**
**
*
CYP2C9,CYP3A4
A13078CC-223
**
cFMS,FLT4,DNA-PK
A16276Voxtalisib
*
PI3Kγ,PI3Kα,PI3Kδ
A11950Zotarolimus
***
A10389Tacrolimus
A11162BGT226
PI3Kα,PI3Kγ,PI3Kβ
A10693Palomid 529
A10210Chrysophanic Acid
EGFR
A11537QL-IX-55
A12480VS-5584
****
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A12704SF1126
PI3K
A12935PF-04979064
****
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ, Akt
A14432GNE-493
***
PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ
A15175mTOR inhibitor (mTOR-IN-1)
***
A15508MHY1485
A16126LY3023414
PI3Kα, Akt1, DNA-PK

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GSK2126458 (Omipalisib)

    Catalog No. A11035
    mTOR/PI3K Inhibitor,
    GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models. Learn More
  2. mTOR inhibitor (mTOR-IN-1)

    Catalog No. A15175
    mTOR inhibitor
    mTOR inhibitor is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 1.5 nM. Learn More
  3. PF-04691502

    Catalog No. A11024
    PI3K/mTOR Inhibitor
    PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway. Learn More
  4. mTOR/PI3K Inhibitor
    GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively. Learn More
  5. MHY1485

    Catalog No. A15508
    mTOR inhibitor
    MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes. Learn More
  6. VS-5584

    Catalog No. A12480
    PI3K/mTOR inhibitor
    VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  7. QL-IX-55

    Catalog No. A11537
    mTORC1/2 inhibitor
    QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively. Learn More
  8. LY3023414

    Catalog No. A16126
    PI3K/mTOR Dual Inhibitor
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). Learn More
  9. PI3K/mTOR dual inhibitor
    SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Learn More
  10. PI3K/mTOR Inhibitor
    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More
  11. PF-04979064

    Catalog No. A12935
    PI3K/mTOR Dual Inhibitor
    PF-04979064 is a highly potent and orally bioavailable PI3K/mTOR dual inhibitor. Learn More
  12. ETP-46464

    Catalog No. A13328
    ATR inhibitor
    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More
  13. XL388

    Catalog No. A12395
    mTOR inhibitor
    XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). Learn More
  14. Torin 1

    Catalog No. A11587
    mTOR inhibitor
    Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM. Learn More
  15. Torin 2

    Catalog No. A11586
    mTOR inhibitor
    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Learn More
  16. Zotarolimus

    Catalog No. A11950
    mTOR inhibitor
    Zotarolimus is an immunosuppressant. It is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Learn More
  17. GDC-0349

    Catalog No. A11443
    mTOR inhibitor
    GDC-0349 is under evaluating the Safety and Tolerability in Patients with locally advanced or metastatic solid tumors or non hodgkin's lymphoma. Learn More
  18. GNE 477

    Catalog No. A14114
    PI3K/mTOR inhibitor
    GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. Learn More
  19. GNE-493

    Catalog No. A14432
    Dual Pan PI3k/mTOR inhibitor
    GNE-493 is potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor with potential anticancer activity. Learn More
  20. AP1903

    Catalog No. A13519
    AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Learn More
  21. Desmethyl-VS-5584

    Catalog No. A10900
    PI3K/mTOR inhibitor
    Desmethyl-VS-5584 is a demethyl analogue of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  22. LY 303511

    Catalog No. A15147
    PI3K inhibitor
    LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K. Learn More
  23. CC-115

    Catalog No. A15779
    mTOR/DNA-PK inhibitor
    CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). Learn More
  24. CC-223

    Catalog No. A13078
    mTOR Inhibitor
    CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM). Learn More
  25. INK 128 (MLN0128)

    Catalog No. A11461
    mTOR inhibitor
    INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Learn More
  26. FK-506 (Tacrolimus)

    Catalog No. A10389
    mTOR inhibitor
    FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells. Learn More
  27. Palomid 529 (P529)

    Catalog No. A10693
    AKT Inhibitor
    Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation. Learn More
  28. PP242 (Torkinib)

    Catalog No. A10746
    mTOR Inhibitor
    PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2. Learn More
  29. KU-0063794

    Catalog No. A10505
    mTOR Inhibitor
    KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively). Learn More
  30. Everolimus (RAD001)

    Catalog No. A10374
    mTOR inhibitor
    Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor. Learn More
  31. GSK1059615

    Catalog No. A10438
    mTOR/PI3K Inhibitor
    GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM). Learn More
  32. PI-103

    Catalog No. A10726
    PI3K Inhibitor
    PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Learn More
  33. Rapamycin (Sirolimus)

    Catalog No. A10782
    mTOR Inhibitors
    Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2). Learn More
  34. Temsirolimus (Torisel)

    Catalog No. A10906
    mTOR inhibitor
    Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Learn More
  35. WYE-125132 (WYE-132)

    Catalog No. A11038
    mTOR Inhibitor
    WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks). Learn More
  36. XL765

    Catalog No. A10997
    PI3K inhibitor
    XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone. Learn More
  37. OSI-027

    Catalog No. A11056
    mTOR inhibitor
    OSI-027 is a potent, selective and orally bioavailable mTOR kinase inhibitor that inhibits the kinase activity associated with both the TORC1 and TORC2 complexes of mTOR. Learn More
  38. mTOR Inhibitor

    Deforolimus (Ridaforolimus) is an investigational targeted and small-molecule inhibitor of the protein mTOR. Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis.

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  39. WYE-354

    Catalog No. A10989
    mTOR Inhibitor
    WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases. Learn More
  40. PP121

    Catalog No. A11207
    PI3K Inhibitor
    PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More
  41. WAY-600

    Catalog No. A11188
    mTOR inhibitor

    WAY-600 is a single digit nanomolar inhibitor of the mTOR kinases, with significant selectivity for these enzymes over phosphatidylinositol 3-kinase (PI3K) isofoms (>100-fold).

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  42. WYE-687

    Catalog No. A11187
    mTOR Inhibitor

    WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin(mTOR).

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  43. CH5132799

    Catalog No. A11169
    PI3K inhibitor

    CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM).

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  44. NVP-BGT226

    Catalog No. A11162
    PI3K inhibitor

    NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.

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  45. PKI-587 ( Gedatolisib )

    Catalog No. A11079
    PI3K/mTOR inhibitor
    PKI-587 is a highly potent PI3K/mTOR kinase inhibitor that inhibits PI3K-α,β,γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively. Learn More
  46. AZD8055

    Catalog No. A10114
    mTOR Inhibitor
    AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. Learn More

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