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| Catalog No. | Inhibitor Name | FGFR | FGFR1 | FGFR2 | FGFR3 | FGFR4 | Other |
|---|---|---|---|---|---|---|---|
| A10080 | Ponatinib | **** | Abl,PDGFRα,VEGFR2 | ||||
| A11159 | BGJ398 | **** | **** | **** | ** | VEGFR2,Lyn,Kit | |
| A10137 | Nintedanib | ** | ** | ** | * | VEGFR3,VEGFR2,LCK | |
| A10703 | PD173074 | ** | VEGFR2,c-Src | ||||
| A11411 | Dovitinib | *** | *** | FLT3,c-Kit,VEGFR3/FLT4 | |||
| A11075 | AZD4547 | **** | **** | **** | * | KDR,IGFR | |
| A10715 | Danusertib | ** | Aurora A,Abl,TrkA | ||||
| A10953 | Orantinib | * | PDGFRβ,Flk1 | ||||
| A10254 | Brivanib | * | VEGFR2,Flk1,VEGFR1 | ||||
| A10198 | Dovitinib Dilactic Acid | *** | *** | FLT3,c-Kit,VEGFR3/FLT4 | |||
| A11753 | MK-2461 | ** | ** | ** | |||
| A10162 | Brivanib Alaninate | * | VEGFR2,Flk1,VEGFR1 | ||||
| A13211 | SSR128129E | * | VEGFR2,PDGFRβ | ||||
| A11558 | SU5402 | ** | |||||
| A15534 | BLU9931 | * | * | * | **** | ||
| A12357 | FIIN-2 | **** | *** | ** | ** | FLT3,c-Kit,VEGFR3/FLT4 | |
| A14415 | CH5183284 | *** | *** | *** | * | VEGFR2 | |
| A11244 | LY2874455 | **** | **** | *** | *** | ||
| A15957 | Erdafitinib | ||||||
| A10508 | KW-2449 | ** | FLT3, Bcr-Abl, Aurora A, PDGFRβ, IGF-1R, EGFR | ||||
| A10699 | Pazopanib HCl | * | VEGFR1, VEGFR2, VEGFR3, PDGFR, c-Kit, c-Fms | ||||
| A11518 | Pazopanib | * | VEGFR1, VEGFR2, VEGFR3, PDGFR, c-Kit, c-Fms | ||||
| A13111 | R 1530 | * | Chk2, KDR, FGFR, Aurora A, Cdk2, VEGFR-2, PDGFRβ | ||||
| A15073 | E-3810 | *** | ** | VEGFR1, VEGFR2, VEGFR3 | |||
| A15848 | FIIN-3 | *** | ** | ** | ** | ||
| A15957 | Alofanib (RPT835) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
37 Item(s)
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Dovitinib (TKI-258)
Catalog No. A11411 RTK inhibitorDovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More -
Debio-1347 (CH5183284)
Catalog No. A14415 FGFR1/2/3 inhibitorDebio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. Learn More -
ACTB-1003
Catalog No. A14431 FGFR1 inhibitorACTB-1003 is an oral kinase inhibitor targeting cancer mutations (FGFR inhibition), angiogenesis (inhibition of VEGFR2 and Tie-2) and induces apoptosis (targeting RSK and p70S6K, downstream of PI3 kinase). Learn More -
E-3810
Catalog No. A15073 VEGFR/FGFR InhibitorE-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. Learn More -
NVP-BGJ398 phosphate
Catalog No. A15194 FGFR InhibitorNVP-BGJ398 phosphate is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Learn More -
BLU9931
Catalog No. A15534 FGFR inhibitorBLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM), Learn More -
FIIN-2
Catalog No. A12357 FGFR InhibitorFIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively. Learn More -
FIIN-3
Catalog No. A15848 Irreversible FGFR inhibitorFIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. Learn More -
Alofanib (RPT835)
Catalog No. A15946 FGFR2 InhibitorAlofanib is a potent and selective allosteric inhibitor of FGFR2 with potential anticancer activity. Learn More -
Erdafitinib (JNJ-42756493)
Catalog No. A15957 FGFR inhibitorErdafitinib is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Learn More -
Nintedanib esylate
Catalog No. A16197 RTK inhibitorNintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Learn More -
FGFR4-IN-1
Catalog No. A16251 FGFR4 inhibitorFGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM. Learn More -
H3B-6527
Catalog No. A16252 FGFR4 inhibitorH3B-6527 is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice. Learn More -
Derazantinib (ARQ-087)
Catalog No. A16825 FGFR inhibitorDerazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT. Learn More -
Rogaratinib
Catalog No. A16963 FGFR inhibitorRogaratinib, also known as BAY-1163877, is an aberrant fibroblast growth factor receptor (FGFR) inhibitor. Learn More -
PD166866
Catalog No. A17161 FGFR inhibitorPD166866 is a FGFR1 inhibitor with IC50 value of 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. Learn More -
FGFR1/DDR2 inhibitor 1
Catalog No. A18716 FGFR1/DDR2 inhibitorFGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively. Learn More -
SSR128129E
Catalog No. A13211 FGFR1 inhibitorSSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 uM Learn More -
R1530
Catalog No. A13111 Chk2, KDR, FGFR, Aurora A & Cdk2 inhibitorR1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. Learn More -
XL-228
Catalog No. A13069 IGF-1R, Aurora, FGFR, ABL, SRC inhibitorXL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More -
AP24534 (Ponatinib)
Catalog No. A10080 BCR-ABL inhibitorAP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor. Learn More -
Danusertib (PHA-739358)
Catalog No. A10715 Aurora inhibitorDanusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More -
Bibf1120 (Nintedanib)
Catalog No. A10137 VEGFR inhibitorBIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR. Learn More -
PD173074
Catalog No. A10703 FGFR1/VEGFR2 InhibitorPD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR. Learn More -
TSU-68 (Orantinib, SU6668)
Catalog No. A10953 PDFGRβ inhibitorOrantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3. Learn More -
Brivanib (BMS-540215)
Catalog No. A10254 VEGFR-2 inhibitorBrivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM. Learn More -
Brivanib alaninate (BMS-582664)
Catalog No. A10162 VEGFR inhibitorBrivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling. Learn More -
KW-2449
Catalog No. A10508 FLT3/FGFR/Bcr-Abl/Aurora InhibitorKW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. Learn More -
AZD4547
Catalog No. A11075 FGFR inhibitorAZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively. Learn More -
BGJ398 (NVP-BGJ398)
Catalog No. A11159 FGFR InhibitorBGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively). Learn More -
Pazopanib HCl (GW786034)
Catalog No. A10699 VEGFR/PDGFR/FGFR inhibitorPazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More -
Dovitinib Dilactic acid (TKI258 Dilactic acid)
Catalog No. A10198 RTK inhibitorDovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More -
MK-2461
Catalog No. A11753 c-Met InhibitorMK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Learn More -
Pazopanib (GW-786034)
Catalog No. A11518 VEGFR inhibitorPazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More -
LY 2874455
Catalog No. A11244 FGFR/VEGFR2 inhibitorLY2874455 is a novel and potent FGFR/VEGFR Inhibitor. Learn More -
SU-5402
Catalog No. A11558 VEGFR/FGFR/EGFR inhibitorSU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Learn More -
ODM-203
Catalog No. A19098 FGFR/VEGFR inhibitorODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. Learn More
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