PDGFR

Catalog No.Inhibitor Name PDGFRPDGFRαPDGFRβOther
A10001Sorafenib Tosylate
**
**
Raf-1,VEGFR2/Flk1,B-Raf
A10468Imatinib Mesylate
c-Kit,v-Abl
A10880Sunitinib Malate
****
FLT3,Kit,VEGFR2
A10080Ponatinib
****
Abl,VEGFR2,FGFR1
A10103Axitinib
***
****
VEGFR1/FLT1,VEGFR2/Flk1,VEGFR3
A10259Imatinib
**
c-Kit,v-Abl
A10137Nintedanib
**
**
VEGFR3,VEGFR2,LCK
A10699Pazopanib HCl
**
VEGFR1,VEGFR2,VEGFR3
A11411Dovitinib
*
***
FLT3,c-Kit,FGFR1
A10025Linifanib
**
VEGFR1/FLT1,CSF-1R,FLT3
A11052Crenolanib
****
****
A10558Masitinib
*
*
Kit,Lyn B,Abl1
A10101Tivozanib
***
**
VEGFR2,VEGFR3,EphB2
A10610Amuvatinib
***
c-Kit (D816H),FLT3 (D835Y)
A10608Motesanib Diphosphate
**
VEGFR1,VEGFR2,VEGFR3
A10953Orantinib
***
FGFR1,Flk1
A11350CP-673451
***
****
c-Kit,VEGFR2,VEGFR1
A10502Ki8751
**
VEGFR2,c-Kit,FGFR2
A10903Telatinib
***
c-Kit,VEGFR3,VEGFR2
A11207PP121
****
Hck,VEGFR,mTOR
A11518Pazopanib
**
VEGFR1,VEGFR2,VEGFR3
A10504KRN 633
*
*
VEGFR3,VEGFR2,VEGFR1
A10198Dovitinib Dilactic Acid
*
***
FLT3,c-Kit,VEGFR3/FLT4
A11753MK-2461
***
c-Met (M1250T),c-Met (Y1235D),c-Met (Y1230H)
A14156AZD2932
****
Flt3,VEGFR-2,c-Kit
A15062DCC-2618
***
***
c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

39 Item(s)

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  1. AC710 Mesylate

    Catalog No. A16246
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    FLT3/KIT/PDGFRα/PDGFRβ inhibitor
    AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. Learn More
  2. Regorafenib (BAY 73-4506)

    Catalog No. A10250
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    VEGFR inhibitor
    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More
  3. Flumatinib mesylate

    Catalog No. A13530
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    c-Abl/c-Kit/PDGRFβ inhibitor
    Flumatinib mesylate can reduce the expression of C-MYC, HIF-1 a and VEGF in U266 cell line in a time- and dose-dependent manners, so flumatinib mesylate may become a new drug for MM therapy. Learn More
  4. Ki 20227

    Catalog No. A11472
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    M-CSFR, CSF1R inhibitor
    Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More
  5. R1530

    Catalog No. A13111
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    Chk2, KDR, FGFR, Aurora A & Cdk2 inhibitor
    R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. Learn More
  6. Toceranib (PHA 291639, SU 11654)

    Catalog No. A11581
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    c-Kit, PDGFR, VEGFR inhibitor
    Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Learn More
  7. CP-673451

    Catalog No. A11350
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    PDGFRα/β inhibitor
    CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM. Learn More
  8. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  9. MK-2461

    Catalog No. A11753
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    c-Met Inhibitor
    MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Learn More
  10. AZD 2932

    Catalog No. A14156
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    mutil-targeted protein tyrosine kinase inhibitor
    AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. Learn More
  11. JI-101

    Catalog No. A13545
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    VEGFR2/PDGFRβ/EphB4 inhibitor
    JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRβ), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Learn More
  12. TAK-593

    Catalog No. A13555
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    VEGFR/PDGFR inhibitor
    TAK-593 is an oral formulation containing a small-molecule receptor tyrosine kinase inhibitor of both vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with potential antineoplastic activity. Learn More
  13. DCC-2618

    Catalog No. A15062
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    C-Kit/PDGFR inhibitor
    DCC-2618 is a small molecule inhibitor of c-Kit and PDGFR with IC50s of 6 nM/30 nM/13 nM for c-Kit/PDGFRα/PDGFRβ respectively. Learn More
  14. Masitinib mesylate

    Catalog No. A15152
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    KIT/PDGFR inhibitor
    Masitinib mesylate is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Learn More
  15. N-Desethyl Sunitinib

    Catalog No. A15182
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    VEGFR/PDGFRβ/KIT inhibitor
    N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Learn More
  16. Toceranib phosphate

    Catalog No. A15263
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    Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Learn More
  17. AC710

    Catalog No. A15933
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    FLT3/KIT/PDGFRα/PDGFRβ inhibitor
    AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. Learn More
  18. Nintedanib esylate

    Catalog No. A16197
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    RTK inhibitor
    Nintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Learn More
  19. KRN 633

    Catalog No. A10504
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    VEGFR Inhibitor
    KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ≥ 10 μM). Learn More
  20. Ki8751

    Catalog No. A10502
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    VEGFR-2 inhibitor
    Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays. Learn More
  21. Dovitinib Dilactic acid (TKI258 Dilactic acid)

    Catalog No. A10198
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    RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  22. Imatinib (Gleevec)

    Catalog No. A10259
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    PDGFR inhibitor
    Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor. Learn More
  23. Sorafenib (Nexavar)

    Catalog No. A10001
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    Raf inhibitor
    Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Learn More
  24. Axitinib

    Catalog No. A10103
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    VEGFR inhibitor
    Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). Learn More
  25. Masitinib ( AB1010)

    Catalog No. A10558
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  26. AP24534 (Ponatinib)

    Catalog No. A10080
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    BCR-ABL inhibitor
    AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor. Learn More
  27. MP470 (MP-470, Amuvatinib)

    Catalog No. A10610
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    RTK inhibitor
    MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor. Learn More
  28. Tivozanib (AV-951)

    Catalog No. A10101
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    VEGFR Inhibitor
    Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors. Learn More
  29. Bibf1120 (Nintedanib)

    Catalog No. A10137
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  30. TSU-68 (Orantinib, SU6668)

    Catalog No. A10953
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    PDFGRβ inhibitor
    Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3. Learn More
  31. Crenolanib (CP-868596)

    Catalog No. A11052
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    PDGFR Inhibitor
    Crenolanib (CP-868596) is an orally bioavailable, selective small molecule inhibitor of the PDGFR tyrosine kinase, inhibiting both PDGFRA and PDGFRB at picomolar concentrations. Learn More
  32. Linifanib (ABT-869)

    Catalog No. A10025
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    VEGFR/PDGFR inhibitor
    Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. Learn More
  33. Imatinib Mesylate

    Catalog No. A10468
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    Bcr-Abl inhibitor
    Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway. Learn More
  34. Telatinib (BAY 57-9352)

    Catalog No. A10903
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    VEGFR-2 inhibitor
    Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Learn More
  35. PP121

    Catalog No. A11207
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    PI3K Inhibitor
    PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More
  36. Motesanib Diphosphate (AMG-706)

    Catalog No. A10608
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    VEGFR inhibitor
    Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors. Learn More
  37. Pazopanib HCl (GW786034)

    Catalog No. A10699
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    VEGFR/PDGFR/FGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  38. Sunitinib Malate

    Catalog No. A10880
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    Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Learn More
  39. Flumatinib

    Catalog No. A16258
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    multi-kinase inhibitor
    Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRbeta and c-Kit respectively. Learn More

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