CDK
Catalog No. | Inhibitor Name | CDK1 | CDK2 | CDK3 | CDK4 | CDK5 | CDK6 | CDK7 | CDK8 | CDK9 | CLK | CDK | Cdc | Other |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A10701 | Palbociclib HCl | **** | *** | |||||||||||
A10806 | Roscovitine | * | ** | * | ERK2,GST-ERK1,ERK1 | |||||||||
A10850 | SNS-032 | * | *** | * | * | ** | **** | GSK-3α,GSK-3β | ||||||
A11129 | Dinaciclib | **** | **** | **** | **** | |||||||||
A10390 | Flavopiridol | *** | *** | *** | ** | * | ||||||||
A10093 | AT7519 | ** | ** | ** | *** | ** | * | **** | GSK-3β | |||||
A11045 | Flavopiridol HCl | *** | *** | * | *** | *** | * | |||||||
A10494 | JNJ-7706621 | **** | **** | * | ** | Aurora A,Aurora B,VEGFR2 | ||||||||
A11105 | AZD5438 | *** | **** | ** | *** | |||||||||
A11167 | MK-8776 | ** | Chk1,Chk2 | |||||||||||
A10716 | PHA-793887 | ** | **** | ** | **** | **** | ** | GSK-3β | ||||||
A10163 | BS-181 HCl | *** | ||||||||||||
A13811 | Palbociclib Isethionate | **** | *** | |||||||||||
A11034 | A-674563 | ** | Akt1,PKA,GSK-3β | |||||||||||
A16386 | abemaciclib | **** | **** | |||||||||||
A11154 | BMS-265246 | **** | **** | ** | ||||||||||
A11164 | PHA-767491 | ** | ** | * | *** | **** | **** | GSK-3β,MK2,PLK1 | ||||||
A11047 | Milciclib | * | *** | ** | * | ** | TrkA | |||||||
A11190 | R547 | **** | **** | **** | GSK-3β | |||||||||
A14136 | NU6027 | * | * | ATR,DNA-PK | ||||||||||
A13547 | P276-00 | ** | ** | ** | * | * | *** | GSK-3β,PKCα,c-Src | ||||||
A11220 | Kenpaullone | * | * | * | GSK-3β,ERK2,c-Src | |||||||||
A15889 | K03861 | **** | ||||||||||||
A14192 | THZ1 | **** | ||||||||||||
A11313 | AT7519 HCl | ** | ** | * | ** | *** | ** | * | **** | GSK-3β | ||||
A15517 | Purvalanol A | *** | * | **** | ||||||||||
A14437 | Ro-3306 | *** | PKCδ,SGK,ERK | |||||||||||
A14318 | SU9516 | *** | *** | ** | PDGFR | |||||||||
A13677 | XL413 | **** | **** | Pim1,CK2 | ||||||||||
A14273 | LDC000067 | * | * | * | *** | |||||||||
A14297 | ML167 | ** | ||||||||||||
A13721 | TG003 | *** | ||||||||||||
A13549 | Ribociclib | |||||||||||||
A12216 | Wogonin | |||||||||||||
A10471 | Indirubin | * | GSK-3β | |||||||||||
A11347 | CGP60474 | *** | *** | PKCα | ||||||||||
A12352 | Purvalanol B | **** | **** | |||||||||||
A12438 | NU 6102 | *** | **** | * | ||||||||||
A12989 | LY2835219 (abemaciclib) | **** | *** | |||||||||||
A14025 | AMG-925 | * | **** | FLT3 | ||||||||||
A15054 | CVT 313 | * | * | * | ||||||||||
A15196 | NVP-LCQ195 | **** | *** | **** | CHK2 | |||||||||
A15767 | NU2058 | * | * | DNA topoisomerase II ATPase | ||||||||||
A15823 | LY2857785 | * | *** | *** |
Notes:
1.Hover mouse over " " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
-
PD 0332991 HCl (Palbociclib)
Catalog No. A10701 CDK 4/6 inhibitorPD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More -
Flavopiridol (Alvocidib)
Catalog No. A10390 CDK inhibitorFlavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More -
A-674563
Catalog No. A11034 Akt inhibitorA-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More -
Roscovitine (Seliciclib)
Catalog No. A10806 CDK InhibitorRoscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9. Learn More -
PHA-793887
Catalog No. A10716 CDK InhibitorPHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines. Learn More -
PHA-767491
Catalog No. A11164 Cdc7/cdk9 inhibitorPHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.
Learn More -
SCH 900776 (MK-8776)
Catalog No. A11167 Chk1 inhibitorSCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.
Learn More -
Dinaciclib (SCH 727965)
Catalog No. A11129 CDK InhibitorDinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively. Learn More -
Kenpaullone
Catalog No. A11220 CDK inhibitorKenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. Learn More -
BAY 1000394 (Roniciclib)
Catalog No. A12742 CDK inhibitorBAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More -
LY2835219 (abemaciclib)
Catalog No. A12989 CDK4/6 inhibitorLY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Learn More -
BMS-863233 (XL-413)
Catalog No. A13677 CDK inhibitorBMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. Learn More -
P276-00
Catalog No. A13547 CDK InhibitorP276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3 Learn More -
LEE011 (Ribociclib)
Catalog No. A13549 CDK4/6 inhibitorLEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Learn More -
LDC000067
Catalog No. A14273 -
PD 0332991 Isethionate
Catalog No. A13811 CDK4/6 inhibitorPD 0332991 Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively. Learn More -
AMG-925
Catalog No. A14025 Dual FLT3/CDK4 inhibitorAMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More -
CVT-313
Catalog No. A15054 CDK2 InhibitorCVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1). Learn More -
Purvalanol A
Catalog No. A15517 CDK inhibitorPurvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More -
NVP-LCQ195
Catalog No. A15196 CDK inhibitorNVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. Learn More -
AG-024322
Catalog No. A15485 CDK inhibitorAG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Learn More -
NU2058
Catalog No. A15767 CDK inhibitorNU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1. Learn More -
Palbociclib
Catalog No. A14427 CDK inhibitorPalbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More -
CDK8-IN-1
Catalog No. A12961 CDK8 inhibitorCDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. Learn More -
CDK-IN-2
Catalog No. A11353 CDK9 inhibitorCDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. Learn More -
Senexin A
Catalog No. A21166 -
Voruciclib hydrochloride
Catalog No. A21385 CDK inhibitorVoruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. Learn More -
PHA-767491 hydrochloride
Catalog No. A21395 dual Cdc7/Cdk9 inhibitorPHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. Learn More -
CDKI-73
Catalog No. A21467 CDK9 inhibitorCDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). Learn More -
CDK9-IN-1
Catalog No. A21552 CDK9 inhibitorCDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87. Learn More -
(±)-BAY-1251152
Catalog No. A21564 PTEF/CDK9 inhibitor(±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. Learn More -
(-)-BAY-1251152
Catalog No. A21570 PTEF/CDK9 inhibitor(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. Learn More -
Lerociclib dihydrochloride
Catalog No. A21577 CDK4/CDK6 inhibitorLerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. Learn More -
LDC4297
Catalog No. A21613 CDK7 inhibitorLDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. Learn More -
BS-181 hydrochloride
Catalog No. A21988 CDK7 inhibitorBS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. Learn More -
SEL120-34A HCl
Catalog No. A21485 CDK8 inhibitorSEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. Learn More -
NU6300
Catalog No. A21025 ATP-competitive CDK2 inhibitorNU6300 is the first covalent ATP-competitive CDK2 inhibitor. Learn More -
CDK8-IN-4
Catalog No. A19820 CDK8 inhibitorCDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM. Learn More -
CDK8-IN-3
Catalog No. A19829 CDK8 inhibitorCDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7. Learn More -
CDK8/19-IN-1
Catalog No. A19986 CDK8/19 dual inhibitorCDK8/19-IN-1 is a potent, selective and oral bioavailable CDK8/19 dual inhibitor, with IC50s of 0.46 nM, 0.99 nM and 270 nM for CDK8, CDK19 and CDK9, respectively. Learn More -
PROTAC CDK9 Degrader-1
Catalog No. A20040 -
CDK9-IN-8
Catalog No. A20196 CDK9 inhibitorCDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM. Learn More -
NU6140
Catalog No. A20264 CDK2-cyclin A inhibitorNU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. Learn More -
Alsterpaullone
Catalog No. A20318 CDK inhibitorAlsterpaullone (9-Nitropaullone;NSC 705701) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Learn More -
BGG463
Catalog No. A20420 -
CYC065
Catalog No. A20512 CDK2/9 inhibitorCYC065 is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50s of 5 and 26 nM, respectively. Learn More -
CCT-251921
Catalog No. A20610 CDK8 inhibitorCCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM. Learn More -
THZ2
Catalog No. A22026 CDK7 inhibitorTHZ2 is a potent and selective CDK7 inhibitor with an IC50 of 13.9 nM. Learn More -
Trilaciclib hydrochloride
Catalog No. A22034 CDK4/6 inhibitorTrilaciclib hydrochloride is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively. Learn More -
6-(Dimethylamino)purine
Catalog No. A22366 dual inhibitor of protein kinase and CDK6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK. Learn More