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  1. Inhibitor (96)
  2. Agonist (1)
  3. Degrader (1)
Target
  1. Aurora A (1)
  2. Aurora B (1)
  3. CDK (3)
  4. CDK4 (2)
  5. FLT3 (3)
  6. JAK2 (2)
Catalog No.Inhibitor Name CDK1CDK2CDK3CDK4CDK5CDK6CDK7CDK8CDK9CLKCDKCdcOther
A10701Palbociclib HCl
****
***
A10806Roscovitine
*
**
*
ERK2,GST-ERK1,ERK1
A10850SNS-032
*
***
*
*
**
****
GSK-3α,GSK-3β
A11129Dinaciclib
****
****
****
****
A10390Flavopiridol
***
***
***
**
*
A10093AT7519
**
**
**
***
**
*
****
GSK-3β
A11045Flavopiridol HCl
***
***
*
***
***
*
A10494JNJ-7706621
****
****
*
**
Aurora A,Aurora B,VEGFR2
A11105AZD5438
***
****
**
***
A11167MK-8776
**
Chk1,Chk2
A10716PHA-793887
**
****
**
****
****
**
GSK-3β
A10163BS-181 HCl
***
A13811Palbociclib Isethionate
****
***
A11034A-674563
**
Akt1,PKA,GSK-3β
A16386abemaciclib
****
****
A11154BMS-265246
****
****
**
A11164PHA-767491
**
**
*
***
****
****
GSK-3β,MK2,PLK1
A11047Milciclib
*
***
**
*
**
TrkA
A11190R547
****
****
****
GSK-3β
A14136NU6027
*
*
ATR,DNA-PK
A13547P276-00
**
**
**
*
*
***
GSK-3β,PKCα,c-Src
A11220Kenpaullone
*
*
*
GSK-3β,ERK2,c-Src
A15889K03861
****
A14192THZ1
****
A11313AT7519 HCl
**
**
*
**
***
**
*
****
GSK-3β
A15517Purvalanol A
***
*
****
A14437Ro-3306
***
PKCδ,SGK,ERK
A14318SU9516
***
***
**
PDGFR
A13677XL413
****
****
Pim1,CK2
A14273LDC000067
*
*
*
***
A14297ML167
**
A13721TG003
***
A13549Ribociclib
A12216Wogonin
A10471Indirubin
*
GSK-3β
A11347CGP60474
***
***
PKCα
A12352Purvalanol B
****
****
A12438NU 6102
***
****
*
A12989LY2835219 (abemaciclib)
****
***
A14025AMG-925
*
****
FLT3
A15054CVT 313
*
*
*
A15196NVP-LCQ195
****
***
****
CHK2
A15767NU2058
*
*
DNA topoisomerase II ATPase
A15823LY2857785
*
***
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. NU6300

    Catalog No. A21025
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    ATP-competitive CDK2 inhibitor
    NU6300 is the first covalent ATP-competitive CDK2 inhibitor. Learn More
  2. AG-024322

    Catalog No. A15485
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    CDK inhibitor
    AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Learn More
  3. NU2058

    Catalog No. A15767
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    CDK inhibitor
    NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1. Learn More
  4. Palbociclib

    Catalog No. A14427
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    CDK inhibitor
    Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  5. CDK8-IN-1

    Catalog No. A12961
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    CDK8 inhibitor
    CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. Learn More
  6. CDK-IN-2

    Catalog No. A11353
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    CDK9 inhibitor
    CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. Learn More
  7. Senexin A

    Catalog No. A21166
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    CDK8 inhibitor
    Senexin A is a CDK8 inhibitor with an IC50 of 280 nM. Learn More
  8. Voruciclib hydrochloride

    Catalog No. A21385
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    CDK inhibitor
    Voruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. Learn More
  9. PHA-767491 hydrochloride

    Catalog No. A21395
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    dual Cdc7/Cdk9 inhibitor
    PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. Learn More
  10. CDKI-73

    Catalog No. A21467
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    CDK9 inhibitor
    CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). Learn More
  11. CDK9-IN-1

    Catalog No. A21552
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    CDK9 inhibitor
    CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87. Learn More
  12. (±)-BAY-1251152

    Catalog No. A21564
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    PTEF/CDK9 inhibitor
    (±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. Learn More
  13. (-)-BAY-1251152

    Catalog No. A21570
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    PTEF/CDK9 inhibitor
    (-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. Learn More
  14. Lerociclib dihydrochloride

    Catalog No. A21577
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    CDK4/CDK6 inhibitor
    Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. Learn More
  15. LDC4297

    Catalog No. A21613
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    CDK7 inhibitor
    LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. Learn More
  16. BS-181 hydrochloride

    Catalog No. A21988
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    CDK7 inhibitor
    BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. Learn More
  17. SEL120-34A HCl

    Catalog No. A21485
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    CDK8 inhibitor
    SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. Learn More
  18. NVP-LCQ195

    Catalog No. A15196
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    CDK inhibitor
    NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. Learn More
  19. Purvalanol A

    Catalog No. A15517
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    CDK inhibitor
    Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More
  20. CVT-313

    Catalog No. A15054
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    CDK2 Inhibitor
    CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1). Learn More
  21. PD 0332991 HCl (Palbociclib)

    Catalog No. A10701
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    CDK 4/6 inhibitor
    PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  22. Flavopiridol (Alvocidib)

    Catalog No. A10390
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    CDK inhibitor
    Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More
  23. A-674563

    Catalog No. A11034
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    Akt inhibitor
    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
  24. Roscovitine (Seliciclib)

    Catalog No. A10806
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    CDK Inhibitor
    Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9. Learn More
  25. PHA-793887

    Catalog No. A10716
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    CDK Inhibitor
    PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines. Learn More
  26. PHA-767491

    Catalog No. A11164
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    Cdc7/cdk9 inhibitor

    PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.

    Learn More
  27. SCH 900776 (MK-8776)

    Catalog No. A11167
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    Chk1 inhibitor

    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

    Learn More
  28. Dinaciclib (SCH 727965)

    Catalog No. A11129
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    CDK Inhibitor
    Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively. Learn More
  29. Kenpaullone

    Catalog No. A11220
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    CDK inhibitor
    Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. Learn More
  30. BAY 1000394 (Roniciclib)

    Catalog No. A12742
    CDK inhibitor
    BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  31. AMG-925

    Catalog No. A14025
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    Dual FLT3/CDK4 inhibitor
    AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More
  32. PD 0332991 Isethionate

    Catalog No. A13811
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  33. LDC000067

    Catalog No. A14273
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    CDK inhibitor
    LDC000067 is a highly selective CDK9 inhibitor . Learn More
  34. LEE011 (Ribociclib)

    Catalog No. A13549
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    CDK4/6 inhibitor
    LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Learn More
  35. P276-00

    Catalog No. A13547
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    CDK Inhibitor
    P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3 Learn More
  36. BMS-863233 (XL-413)

    Catalog No. A13677
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    CDK inhibitor
    BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. Learn More
  37. LY2835219 (abemaciclib)

    Catalog No. A12989
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    CDK4/6 inhibitor
    LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Learn More
  38. Atuveciclib (BAY-1143572)

    Catalog No. A16810
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    Selective PTEFb/CDK9 inhibitor
    Atuveciclib, also known as BAY1143572, is a highly selective, potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I. Learn More
  39. ICEC0942 HCl

    Catalog No. A16903
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    CDK7 inhibitor
    ICEC0942, also known as CT7001, is an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. It selectively inhibits CDK7, with an IC50 of 40nM; IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. Learn More
  40. PF-06873600

    Catalog No. A16875
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    CDK inhibitor
    PF-06873600 is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Learn More
  41. SEL120-34A

    Catalog No. A17086
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    CDK8 inhibitor
    SEL120-34A is a potent and selective CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Learn More
  42. Trilaciclib

    Catalog No. A17084
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    CDK4/6 inhibitor
    Trilaciclib is a potential first-in-class short-acting CDK4/6 inhibitor in development to preserve hematopoietic stem cells and enhance immune system function during chemotherapy. Learn More
  43. THZ531

    Catalog No. A17036
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    CDK12 and CDK13 covalent inhibitor
    THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. THZ531 irreversibly targets a cysteine located outside the kinase domain. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II. Learn More
  44. SB1317 (TG02)

    Catalog No. A13454
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    CDK/JAK2/FLT3 inhibitor
    SB1317 is a potent inhibitor of Cyclin dependent kinases (CDKs), FMS-like tyrosine kinase-3 (FLT3) and Janus kinase 2 (JAK2) with IC50 values of 13nM, 56nM and 73nM for CDK2, JAK2 and FLT3, respectively. Learn More
  45. LY2835219 methanesulfonate

    Catalog No. A16386
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    CDK4/6 inhibitor
    LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3. Learn More
  46. LY-3177833

    Catalog No. A16325
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    CDC7 inhibitor
    LY-3177833 is a potent and selective inhibitor of CDC7 (Cell Division Cycle 7-related Protein Kinase). Learn More
  47. Bohemine

    Catalog No. A15942
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    CDK inhibitor
    Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor with IC50 = 1 ,M. Learn More
  48. K03861

    Catalog No. A15889
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    CDK inhibitor
    K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. Learn More
  49. ON123300

    Catalog No. A12584
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    CDK4 inhibitor‎
    ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as ??-type platelet-derived growth factor receptor (PDGFR??). Learn More
  50. RGB-286638

    Catalog No. A13130
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    CDK inhibitor
    RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6. Learn More

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