CDK

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Target
  1. Aurora A (1)
  2. Aurora B (1)
  3. CDK (2)
  4. CDK4 (1)
  5. FLT3 (2)
  6. JAK2 (1)
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  1. Inhibitor (65)
Catalog No.Inhibitor Name CDK1CDK2CDK3CDK4CDK5CDK6CDK7CDK8CDK9CLKCDKCdcOther
A10701Palbociclib HCl
****
***
A10806Roscovitine
*
**
*
ERK2,GST-ERK1,ERK1
A10850SNS-032
*
***
*
*
**
****
GSK-3α,GSK-3β
A11129Dinaciclib
****
****
****
****
A10390Flavopiridol
***
***
***
**
*
A10093AT7519
**
**
**
***
**
*
****
GSK-3β
A11045Flavopiridol HCl
***
***
*
***
***
*
A10494JNJ-7706621
****
****
*
**
Aurora A,Aurora B,VEGFR2
A11105AZD5438
***
****
**
***
A11167MK-8776
**
Chk1,Chk2
A10716PHA-793887
**
****
**
****
****
**
GSK-3β
A10163BS-181 HCl
***
A13811Palbociclib Isethionate
****
***
A11034A-674563
**
Akt1,PKA,GSK-3β
A16386abemaciclib
****
****
A11154BMS-265246
****
****
**
A11164PHA-767491
**
**
*
***
****
****
GSK-3β,MK2,PLK1
A11047Milciclib
*
***
**
*
**
TrkA
A11190R547
****
****
****
GSK-3β
A14136NU6027
*
*
ATR,DNA-PK
A13547P276-00
**
**
**
*
*
***
GSK-3β,PKCα,c-Src
A11220Kenpaullone
*
*
*
GSK-3β,ERK2,c-Src
A15889K03861
****
A14192THZ1
****
A11313AT7519 HCl
**
**
*
**
***
**
*
****
GSK-3β
A15517Purvalanol A
***
*
****
A14437Ro-3306
***
PKCδ,SGK,ERK
A14318SU9516
***
***
**
PDGFR
A13677XL413
****
****
Pim1,CK2
A14273LDC000067
*
*
*
***
A14297ML167
**
A13721TG003
***
A13549Ribociclib
A12216Wogonin
A10471Indirubin
*
GSK-3β
A11347CGP60474
***
***
PKCα
A12352Purvalanol B
****
****
A12438NU 6102
***
****
*
A12989LY2835219 (abemaciclib)
****
***
A14025AMG-925
*
****
FLT3
A15054CVT 313
*
*
*
A15196NVP-LCQ195
****
***
****
CHK2
A15767NU2058
*
*
DNA topoisomerase II ATPase
A15823LY2857785
*
***
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. LY2835219 (abemaciclib)

    Catalog No. A12989
    CDK4/6 inhibitor
    LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Learn More
  2. NU2058

    Catalog No. A15767
    CDK inhibitor
    NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1. Learn More
  3. AG-024322

    Catalog No. A15485
    CDK inhibitor
    AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Learn More
  4. NVP-LCQ195

    Catalog No. A15196
    CDK inhibitor
    NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. Learn More
  5. Purvalanol A

    Catalog No. A15517
    CDK inhibitor
    Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More
  6. CVT-313

    Catalog No. A15054
    CDK2 Inhibitor
    CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1). Learn More
  7. AMG-925

    Catalog No. A14025
    Dual FLT3/CDK4 inhibitor
    AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More
  8. LDC000067

    Catalog No. A14273
    CDK inhibitor
    LDC000067 is a highly selective CDK9 inhibitor . Learn More
  9. LEE011 (Ribociclib)

    Catalog No. A13549
    CDK4/6 inhibitor
    LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Learn More
  10. P276-00

    Catalog No. A13547
    CDK Inhibitor
    P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3 Learn More
  11. BMS-863233 (XL-413)

    Catalog No. A13677
    CDK inhibitor
    BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. Learn More
  12. CDK9 inhibitor 2

    Catalog No. A15039
    CDK9 inhibitor
    CDK9-IN-2 is a novel cyclin-dependent kinase 9(CDK9) inhibitor. Learn More
  13. AT7519 trifluoroacetate

    Catalog No. A15005
    CDK inhibitor
    AT7519 trifluoroacetate is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM, less potent to CDK3 and little active to CDK7. Learn More
  14. NG52

    Catalog No. A12494
    Cell cycle-regulating kinase inhibitor
    NG52 is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 _mu_M), and the related Pho85p kinase (IC50 = 2 _mu_M). Learn More
  15. LY2857785

    Catalog No. A15823
    CDK9 inhibitor
    LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. Learn More
  16. RGB-286638

    Catalog No. A13130
    CDK inhibitor
    RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6. Learn More
  17. NSC 663284

    Catalog No. A13524
    Cdc25 inhibitor
    NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). Learn More
  18. AZD5597

    Catalog No. A13506
    CDK inhibitor
    AZD5597 is potent CDK inhibitor with in vitro anti-proliferative effects against a range of cancer cell lines. Learn More
  19. PHA690509

    Catalog No. A13550
    CDK inhibitor
    PHA-690509 is a ATP-competitive CDK inhibitor. Learn More
  20. Ro 3306

    Catalog No. A14437
    CDK1 inhibitor
    Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Learn More
  21. CA-224

    Catalog No. A14414
    CDK4 inhibitor
    CA-224 is potent CDK4 inhibitor,is also a nonplanar analogue of fascaplysin that specifically inhibits Cdk4-cyclin D1 in vitro. Learn More
  22. Voruciclib

    Catalog No. A14392
    CDK inhibitor
    Voruciclib is a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  23. SU9516

    Catalog No. A14318
    CDK2 inhibitor
    SU9516 is a potent, selective cdk2 inhibitor. It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Learn More
  24. ON123300

    Catalog No. A12584
    CDK4 inhibitor‎
    ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as ??-type platelet-derived growth factor receptor (PDGFR??). Learn More
  25. Palbociclib

    Catalog No. A14427
    CDK inhibitor
    Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  26. NVP-2

    Catalog No. A17022
    CDK9 Inhibitor
    NVP-2 is a potent and selective ATP-competitive CDK9 inhibitor with IC50 value of 0.5 nM. Learn More
  27. BAY-1251152

    Catalog No. A17029
    CDK9 inhibitor
    BAY-1251152, also known as (+)-BAY-1251152, is a CDK9 inhibitor. Learn More
  28. THZ531

    Catalog No. A17036
    CDK12 and CDK13 covalent inhibitor
    THZ531 is a covalent CDK12 and CDK13 covalent inhibitor. THZ531 irreversibly targets a cysteine located outside the kinase domain. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II. Learn More
  29. Trilaciclib

    Catalog No. A17084
    CDK4/6 inhibitor
    Trilaciclib is a potential first-in-class short-acting CDK4/6 inhibitor in development to preserve hematopoietic stem cells and enhance immune system function during chemotherapy. Learn More
  30. SEL120-34A HCl

    Catalog No. A17086
    CDK8 inhibitor
    SEL120-34A is a potent and selective CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Learn More
  31. PF-06873600

    Catalog No. A16875
    CDK inhibitor
    PF-06873600 is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Learn More
  32. ICEC0942 HCl

    Catalog No. A16903
    CDK7 inhibitor
    ICEC0942, also known as CT7001, is an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. It selectively inhibits CDK7, with an IC50 of 40nM; IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. Learn More
  33. Atuveciclib (BAY-1143572)

    Catalog No. A16810
    Selective PTEFb/CDK9 inhibitor
    Atuveciclib, also known as BAY1143572, is a highly selective, potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I. Learn More
  34. SB1317 (TG02)

    Catalog No. A13454
    CDK/JAK2/FLT3 inhibitor
    SB1317 is a potent inhibitor of Cyclin dependent kinases (CDKs), FMS-like tyrosine kinase-3 (FLT3) and Janus kinase 2 (JAK2) with IC50 values of 13nM, 56nM and 73nM for CDK2, JAK2 and FLT3, respectively. Learn More
  35. LY2835219 methanesulfonate

    Catalog No. A16386
    CDK4/6 inhibitor
    LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3. Learn More
  36. LY-3177833

    Catalog No. A16325
    CDC7 inhibitor
    LY-3177833 is a potent and selective inhibitor of CDC7 (Cell Division Cycle 7-related Protein Kinase). Learn More
  37. Bohemine

    Catalog No. A15942
    CDK inhibitor
    Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor with IC50 = 1 ,M. Learn More
  38. K03861

    Catalog No. A15889
    CDK inhibitor
    K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. Learn More
  39. ML167

    Catalog No. A14297
    Clk4 inhibitor
    ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor Learn More
  40. NU6027

    Catalog No. A14136
    ATR/CDK inhibitor
    NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. Learn More
  41. AZD5438

    Catalog No. A11105
    CDK inhibitor
    AZD5438 is a potent inhibitor of cyclin-dependent kinase (CDK) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Learn More
  42. PHA-848125 (Milciclib)

    Catalog No. A11047
    CDK Inhibitor
    PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity. Learn More
  43. JNJ-7706621

    Catalog No. A10494
    CDK/Aurora A/B Inhibitor
    JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1. Learn More
  44. Flavopiridol HCl

    Catalog No. A11045
    CDK inhibitor
    Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells. Learn More
  45. BS-181 HCl

    Catalog No. A10163
    CDK inhibitor
    BS-181 HCl is a potential anti-tumor agent as CDK7 inhibitor. Learn More
  46. AT7519

    Catalog No. A10093
    CDK Inhibitor
    AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Learn More
  47. PHA-793887

    Catalog No. A10716
    CDK Inhibitor
    PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines. Learn More
  48. SNS-032 (BMS-387032)

    Catalog No. A10850
    CDK inhibitor
    SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells. Learn More
  49. Roscovitine (Seliciclib)

    Catalog No. A10806
    CDK Inhibitor
    Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9. Learn More

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