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  1. Inhibitor (96)
  2. Agonist (1)
  3. Degrader (1)
Target
  1. Aurora A (1)
  2. Aurora B (1)
  3. CDK (3)
  4. CDK4 (2)
  5. FLT3 (3)
  6. JAK2 (2)
Catalog No.Inhibitor Name CDK1CDK2CDK3CDK4CDK5CDK6CDK7CDK8CDK9CLKCDKCdcOther
A10701Palbociclib HCl
****
***
A10806Roscovitine
*
**
*
ERK2,GST-ERK1,ERK1
A10850SNS-032
*
***
*
*
**
****
GSK-3α,GSK-3β
A11129Dinaciclib
****
****
****
****
A10390Flavopiridol
***
***
***
**
*
A10093AT7519
**
**
**
***
**
*
****
GSK-3β
A11045Flavopiridol HCl
***
***
*
***
***
*
A10494JNJ-7706621
****
****
*
**
Aurora A,Aurora B,VEGFR2
A11105AZD5438
***
****
**
***
A11167MK-8776
**
Chk1,Chk2
A10716PHA-793887
**
****
**
****
****
**
GSK-3β
A10163BS-181 HCl
***
A13811Palbociclib Isethionate
****
***
A11034A-674563
**
Akt1,PKA,GSK-3β
A16386abemaciclib
****
****
A11154BMS-265246
****
****
**
A11164PHA-767491
**
**
*
***
****
****
GSK-3β,MK2,PLK1
A11047Milciclib
*
***
**
*
**
TrkA
A11190R547
****
****
****
GSK-3β
A14136NU6027
*
*
ATR,DNA-PK
A13547P276-00
**
**
**
*
*
***
GSK-3β,PKCα,c-Src
A11220Kenpaullone
*
*
*
GSK-3β,ERK2,c-Src
A15889K03861
****
A14192THZ1
****
A11313AT7519 HCl
**
**
*
**
***
**
*
****
GSK-3β
A15517Purvalanol A
***
*
****
A14437Ro-3306
***
PKCδ,SGK,ERK
A14318SU9516
***
***
**
PDGFR
A13677XL413
****
****
Pim1,CK2
A14273LDC000067
*
*
*
***
A14297ML167
**
A13721TG003
***
A13549Ribociclib
A12216Wogonin
A10471Indirubin
*
GSK-3β
A11347CGP60474
***
***
PKCα
A12352Purvalanol B
****
****
A12438NU 6102
***
****
*
A12989LY2835219 (abemaciclib)
****
***
A14025AMG-925
*
****
FLT3
A15054CVT 313
*
*
*
A15196NVP-LCQ195
****
***
****
CHK2
A15767NU2058
*
*
DNA topoisomerase II ATPase
A15823LY2857785
*
***
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. PD 0332991 HCl (Palbociclib)

    Catalog No. A10701
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    CDK 4/6 inhibitor
    PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  2. Flavopiridol (Alvocidib)

    Catalog No. A10390
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    CDK inhibitor
    Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia. Learn More
  3. A-674563

    Catalog No. A11034
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    Akt inhibitor
    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
  4. Roscovitine (Seliciclib)

    Catalog No. A10806
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    CDK Inhibitor
    Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9. Learn More
  5. PHA-793887

    Catalog No. A10716
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    CDK Inhibitor
    PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines. Learn More
  6. PHA-767491

    Catalog No. A11164
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    Cdc7/cdk9 inhibitor

    PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.

    Learn More
  7. SCH 900776 (MK-8776)

    Catalog No. A11167
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    Chk1 inhibitor

    SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

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  8. Dinaciclib (SCH 727965)

    Catalog No. A11129
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    CDK Inhibitor
    Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively. Learn More
  9. Kenpaullone

    Catalog No. A11220
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    CDK inhibitor
    Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. Learn More
  10. BAY 1000394 (Roniciclib)

    Catalog No. A12742
    CDK inhibitor
    BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  11. LY2835219 (abemaciclib)

    Catalog No. A12989
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    CDK4/6 inhibitor
    LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Learn More
  12. BMS-863233 (XL-413)

    Catalog No. A13677
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    CDK inhibitor
    BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. Learn More
  13. P276-00

    Catalog No. A13547
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    CDK Inhibitor
    P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3 Learn More
  14. LEE011 (Ribociclib)

    Catalog No. A13549
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    CDK4/6 inhibitor
    LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Learn More
  15. LDC000067

    Catalog No. A14273
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    CDK inhibitor
    LDC000067 is a highly selective CDK9 inhibitor . Learn More
  16. PD 0332991 Isethionate

    Catalog No. A13811
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  17. AMG-925

    Catalog No. A14025
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    Dual FLT3/CDK4 inhibitor
    AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. Learn More
  18. CVT-313

    Catalog No. A15054
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    CDK2 Inhibitor
    CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 215 uM for Cdk4/D1). Learn More
  19. Purvalanol A

    Catalog No. A15517
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    CDK inhibitor
    Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn More
  20. NVP-LCQ195

    Catalog No. A15196
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    CDK inhibitor
    NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. Learn More
  21. AG-024322

    Catalog No. A15485
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    CDK inhibitor
    AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Learn More
  22. NU2058

    Catalog No. A15767
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    CDK inhibitor
    NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1. Learn More
  23. Palbociclib

    Catalog No. A14427
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    CDK inhibitor
    Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Learn More
  24. CDK8-IN-1

    Catalog No. A12961
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    CDK8 inhibitor
    CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. Learn More
  25. CDK-IN-2

    Catalog No. A11353
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    CDK9 inhibitor
    CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. Learn More
  26. Senexin A

    Catalog No. A21166
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    CDK8 inhibitor
    Senexin A is a CDK8 inhibitor with an IC50 of 280 nM. Learn More
  27. Voruciclib hydrochloride

    Catalog No. A21385
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    CDK inhibitor
    Voruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. Learn More
  28. PHA-767491 hydrochloride

    Catalog No. A21395
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    dual Cdc7/Cdk9 inhibitor
    PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. Learn More
  29. CDKI-73

    Catalog No. A21467
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    CDK9 inhibitor
    CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). Learn More
  30. CDK9-IN-1

    Catalog No. A21552
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    CDK9 inhibitor
    CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87. Learn More
  31. (±)-BAY-1251152

    Catalog No. A21564
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    PTEF/CDK9 inhibitor
    (±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. Learn More
  32. (-)-BAY-1251152

    Catalog No. A21570
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    PTEF/CDK9 inhibitor
    (-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. Learn More
  33. Lerociclib dihydrochloride

    Catalog No. A21577
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    CDK4/CDK6 inhibitor
    Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. Learn More
  34. LDC4297

    Catalog No. A21613
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    CDK7 inhibitor
    LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. Learn More
  35. BS-181 hydrochloride

    Catalog No. A21988
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    CDK7 inhibitor
    BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. Learn More
  36. SEL120-34A HCl

    Catalog No. A21485
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    CDK8 inhibitor
    SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. Learn More
  37. NU6300

    Catalog No. A21025
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    ATP-competitive CDK2 inhibitor
    NU6300 is the first covalent ATP-competitive CDK2 inhibitor. Learn More
  38. CDK8-IN-4

    Catalog No. A19820
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    CDK8 inhibitor
    CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM. Learn More
  39. CDK8-IN-3

    Catalog No. A19829
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    CDK8 inhibitor
    CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7. Learn More
  40. CDK8/19-IN-1

    Catalog No. A19986
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    CDK8/19 dual inhibitor
    CDK8/19-IN-1 is a potent, selective and oral bioavailable CDK8/19 dual inhibitor, with IC50s of 0.46 nM, 0.99 nM and 270 nM for CDK8, CDK19 and CDK9, respectively. Learn More
  41. PROTAC CDK9 Degrader-1

    Catalog No. A20040
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    CDK9 degrader
    PROTAC CDK9 Degrader-1 is a selective CDK9 degrader. Learn More
  42. CDK9-IN-8

    Catalog No. A20196
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    CDK9 inhibitor
    CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM. Learn More
  43. NU6140

    Catalog No. A20264
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    CDK2-cyclin A inhibitor
    NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. Learn More
  44. Alsterpaullone

    Catalog No. A20318
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    CDK inhibitor
    Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Learn More
  45. BGG463

    Catalog No. A20420
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    CDK2 inhibitor
    BGG463 (K03859) is an orally active type II CDK2 inhibitor. Learn More
  46. CYC065

    Catalog No. A20512
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    CDK2/9 inhibitor
    CYC065 is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50s of 5 and 26 nM, respectively. Learn More
  47. CCT-251921

    Catalog No. A20610
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    CDK8 inhibitor
    CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM. Learn More
  48. THZ2

    Catalog No. A22026
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    CDK7 inhibitor
    THZ2 is a potent and selective CDK7 inhibitor with an IC50 of 13.9 nM. Learn More
  49. Trilaciclib hydrochloride

    Catalog No. A22034
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    CDK4/6 inhibitor
    Trilaciclib hydrochloride is a CDK4/6 inhibitor with IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively. Learn More
  50. 6-(Dimethylamino)purine

    Catalog No. A22366
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    dual inhibitor of protein kinase and CDK
    6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK. Learn More

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