FGFR

Catalog No.Inhibitor Name FGFRFGFR1FGFR2FGFR3FGFR4Other
A10080Ponatinib
****
Abl,PDGFRα,VEGFR2
A11159BGJ398
****
****
****
**
VEGFR2,Lyn,Kit
A10137Nintedanib
**
**
**
*
VEGFR3,VEGFR2,LCK
A10703PD173074
**
VEGFR2,c-Src
A11411Dovitinib
***
***
FLT3,c-Kit,VEGFR3/FLT4
A11075AZD4547
****
****
****
*
KDR,IGFR
A10715Danusertib
**
Aurora A,Abl,TrkA
A10953Orantinib
*
PDGFRβ,Flk1
A10254Brivanib
*
VEGFR2,Flk1,VEGFR1
A10198Dovitinib Dilactic Acid
***
***
FLT3,c-Kit,VEGFR3/FLT4
A11753MK-2461
**
**
**
A10162Brivanib Alaninate
*
VEGFR2,Flk1,VEGFR1
A13211SSR128129E
*
VEGFR2,PDGFRβ
A11558SU5402
**
A15534BLU9931
*
*
*
****
A12357FIIN-2
****
***
**
**
FLT3,c-Kit,VEGFR3/FLT4
A14415CH5183284
***
***
***
*
VEGFR2
A11244LY2874455
****
****
***
***
A15957Erdafitinib
A10508KW-2449
**
FLT3, Bcr-Abl, Aurora A, PDGFRβ, IGF-1R, EGFR
A10699Pazopanib HCl
*
VEGFR1, VEGFR2, VEGFR3, PDGFR, c-Kit, c-Fms
A11518Pazopanib
*
VEGFR1, VEGFR2, VEGFR3, PDGFR, c-Kit, c-Fms
A13111R 1530
*
Chk2, KDR, FGFR, Aurora A, Cdk2, VEGFR-2, PDGFRβ
A15073E-3810
***
**
VEGFR1, VEGFR2, VEGFR3
A15848FIIN-3
***
**
**
**
A15957Alofanib (RPT835)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

35 Item(s)

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  1. Dovitinib (TKI-258)

    Catalog No. A11411
    RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  2. SSR128129E

    Catalog No. A13211
    FGFR1 inhibitor
    SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 uM Learn More
  3. Debio-1347 (CH5183284)

    Catalog No. A14415
    FGFR1/2/3 inhibitor
    Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. Learn More
  4. ACTB-1003

    Catalog No. A14431
    FGFR1 inhibitor
    ACTB-1003 is an oral kinase inhibitor targeting cancer mutations (FGFR inhibition), angiogenesis (inhibition of VEGFR2 and Tie-2) and induces apoptosis (targeting RSK and p70S6K, downstream of PI3 kinase). Learn More
  5. E-3810

    Catalog No. A15073
    VEGFR/FGFR Inhibitor
    E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. Learn More
  6. NVP-BGJ398 phosphate

    Catalog No. A15194
    FGFR Inhibitor
    NVP-BGJ398 phosphate is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Learn More
  7. BLU9931

    Catalog No. A15534
    FGFR inhibitor
    BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM), Learn More
  8. FIIN-2

    Catalog No. A12357
    FGFR Inhibitor
    FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively. Learn More
  9. Alofanib (RPT835)

    Catalog No. A15946
    FGFR2 Inhibitor
    Alofanib is a potent and selective allosteric inhibitor of FGFR2 with potential anticancer activity. Learn More
  10. Erdafitinib (JNJ-42756493)

    Catalog No. A15957
    FGFR inhibitor
    Erdafitinib is a potent and selective orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Learn More
  11. Nintedanib esylate

    Catalog No. A16197
    RTK inhibitor
    Nintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Learn More
  12. FGFR4-IN-1

    Catalog No. A16251
    FGFR4 inhibitor
    FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM. Learn More
  13. H3B-6527

    Catalog No. A16252
    FGFR4 inhibitor
    H3B-6527 is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice. Learn More
  14. Derazantinib (ARQ-087)

    Catalog No. A16825
    FGFR inhibitor
    Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT. Learn More
  15. Rogaratinib

    Catalog No. A16963
    FGFR inhibitor
    Rogaratinib, also known as BAY-1163877, is an aberrant fibroblast growth factor receptor (FGFR) inhibitor. Learn More
  16. R1530

    Catalog No. A13111
    Chk2, KDR, FGFR, Aurora A & Cdk2 inhibitor
    R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. Learn More
  17. XL-228

    Catalog No. A13069
    IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
    XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More
  18. SU-5402

    Catalog No. A11558
    VVEGFR/FGFR/EGFR inhibitor‎
    SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Learn More
  19. AP24534 (Ponatinib)

    Catalog No. A10080
    BCR-ABL inhibitor
    AP24534 (Ponatinib) is a potent multi-kinase and pan-BCR-ABL inhibitor. Learn More
  20. Danusertib (PHA-739358)

    Catalog No. A10715
    Aurora inhibitor
    Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2 Learn More
  21. PD173074

    Catalog No. A10703
    FGFR1/VEGFR2 Inhibitor
    PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR. Learn More
  22. TSU-68 (Orantinib, SU6668)

    Catalog No. A10953
    PDFGRβ inhibitor
    Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3. Learn More
  23. Brivanib (BMS-540215)

    Catalog No. A10254
    VEGFR-2 inhibitor
    Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM. Learn More
  24. VEGFR inhibitor
    Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling. Learn More
  25. KW-2449

    Catalog No. A10508
    FLT3/FGFR/Bcr-Abl/Aurora Inhibitor
    KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. Learn More
  26. AZD4547

    Catalog No. A11075
    FGFR inhibitor
    AZD4547 is a potent, selective and orally active pan-FGFR inhibitor, with IC50s of 0.2, 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively. Learn More
  27. BGJ398 (NVP-BGJ398)

    Catalog No. A11159
    FGFR Inhibitor
    BGJ398 is a potent and selective inhibitor with potential antiangiogenic and antineoplastic activities of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively). Learn More
  28. Pazopanib HCl (GW786034)

    Catalog No. A10699
    VEGFR/PDGFR/FGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  29. RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  30. MK-2461

    Catalog No. A11753
    c-Met Inhibitor
    MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Learn More
  31. Pazopanib (GW-786034)

    Catalog No. A11518
    VEGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  32. LY 2874455

    Catalog No. A11244
    FGFR/VEGFR2 inhibitor
    LY2874455 is a novel and potent FGFR/VEGFR Inhibitor. Learn More
  33. PD166866

    Catalog No. A17161
    FGFR inhibitor
    PD166866 is a FGFR1 inhibitor with IC50 value of 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. Learn More

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