PI3K



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Catalog No. Product Name Application Product Information
A11151 SALE

3-Methyladenine

Autophagy/PI3K Inhibitor
3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase).
A11202

A66

PI3K inhibitor
The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA).
A14441

Acalisib (GS-9820)

PI3Kδ Inhibitor
Acalisib is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities.
A15901

AMG319

PI3Kδ inhibitor
AMG319 is a potent and selective PI3K?? inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
A11099 SALE

AS-252424

PI3K inhibitor
AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
A11197 SALE

AS-604850

PI3K Inhibitor

AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

A10088

AS-605240

PI3K Inhibitor
AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.
A10112 SALE

AZD6482

PI3K inhibitor
AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy.
A15759 SALE

AZD8186

PI3K inhibitor
AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3K?? (IC50=4 nM) and PI3K?? (IC50=12 nM) with selectivity over PI3K?? (IC50=35 nM) and PI3K?? (IC50=675 nM).
A14164 SALE

AZD8186

PI3K inhibitor
AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity.
A11766 SALE

BAY 80-6946 (Copanlisib)

PI3K inhibitor
BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
A10133 SALE

BEZ235 (NVP-BEZ235, Dactolisib)

PI3K/mTOR Inhibitor
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
A11016 SALE

BKM120 (NVP-BKM120)

PI3K Inhibitor‎
BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
A11328 SALE

BYL719

PI3K Inhibitor
BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
A10172 SALE

CAL-101 (GS-1101)

PI3K inhibitor
CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.
A15030

CAL-130

PI3K inhibitor
CAL-130 is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3K??/?? as therapy for T cell acute lymphoblastic leukemia (T-ALL).
A15031

CAL-130 Hydrochloride

PI3K inhibitor
CAL-130 Hydrochloride is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3K??/?? as therapy for T cell acute lymphoblastic leukemia (T-ALL).
A11196 SALE

CAY10505

PI3K inhibitor

CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).

A11169 SALE

CH5132799

PI3K inhibitor

CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM).

A13879

CNX-1351

PI3Kα inhibitor
A11363 SALE

CZC24832

PI3K inhibitor
CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay).
A11198

D-106669

PI3K Inhibitor

D-106669 is a highly potent and selective PI3K inhibitor, (PI3Kα IC50 <10 nM, >3 log selectivity against tyrosine or serine/threonine kinases, except ERK1 and 2).

A16271

ETP-46321

PI3K α/δ inhibitor
ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing.
A12831 SALE

GDC-0032 (Taselisib)

PI3K inhibitor
GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha.
A16272

GDC-0084

PI3K inhibitor
GDC-0084 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.

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