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PI3-Kinase (PI3K)

Target
  1. DNA-PK (1)
  2. p110α (6)
  3. p110β (2)
  4. p110δ (2)
  5. p110γ (2)


Items 1 to 25 of 63 total

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Set Descending Direction
Catalog No. Product Name Product Information
A11151

3-Methyladenine

3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase). Learn More
A11202

A66

The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA). Learn More
A14441

Acalisib (GS-9820)

Acalisib is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. Learn More
A11099

AS-252424

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively. Learn More
A11197

AS-604850

AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

Learn More
A10088

AS-605240

AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. Learn More
A10112

AZD6482

AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy. Learn More
A15759

AZD8186

AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3K?? (IC50=4 nM) and PI3K?? (IC50=12 nM) with selectivity over PI3K?? (IC50=35 nM) and PI3K?? (IC50=675 nM). Learn More
A11766

BAY 80-6946

BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
A10133

BEZ235 (NVP-BEZ235)

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More
A11016

BKM120 (NVP-BKM120)

BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. Learn More
A11328

BYL719

BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
A10172

CAL-101 (GS-1101)

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells. Learn More
A15030

CAL-130

CAL-130 is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3K??/?? as therapy for T cell acute lymphoblastic leukemia (T-ALL). Learn More
A15031

CAL-130 Hydrochloride

CAL-130 Hydrochloride is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3K??/?? as therapy for T cell acute lymphoblastic leukemia (T-ALL). Learn More
A11196

CAY10505

CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).

Learn More
A11169

CH5132799

CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM).

Learn More
A13879

CNX-1351

A11363

CZC24832

CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Learn More
A11198

D-106669

D-106669 is a highly potent and selective PI3K inhibitor, (PI3Kα IC50 <10 nM, >3 log selectivity against tyrosine or serine/threonine kinases, except ERK1 and 2).

Learn More
A12831

GDC-0032

GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha. Learn More
A10421

GDC-0941

GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Learn More
A11023

GDC-0980 (RG7422)

GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively. Learn More
A10438

GSK1059615

GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM). Learn More
A11035

GSK2126458

GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models. Learn More

Items 1 to 25 of 63 total

per page
Page:
  1. 1
  2. 2
  3. 3

Set Descending Direction
PI3-Kinase (PI3K)

Minimal Price: $30.00