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PI3-Kinase (PI3K)

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  • 3-Methyladenine

    A11151 3-Methyladenine

    3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase).
  • A66

    A11202 A66

    The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA).
  • AS-252424

    A11099 AS-252424

    AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
  • AS-604850

    A11197 AS-604850

    AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

  • AS-605240

    A10088 AS-605240

    AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.
  • AZD6482

    A10112 AZD6482

    AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy.
  • BAY 80-6946

    A11766 BAY 80-6946

    BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
  • BEZ235 (NVP-BEZ235)

    A10133 BEZ235 (NVP-BEZ235)

    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
  • BKM120 (NVP-BKM120)

    A11016 BKM120 (NVP-BKM120)

    BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
  • BYL719

    A11328 BYL719

    BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.

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