PI3K

Catalog No.Inhibitor Name PI3K p110α p110β p110δ p110γC2α C2β Vps34 Other Targets
A10133Dactolisib (BEZ235, NVP-BEZ235)
****
**
***
***
mTOR (p70S6K),ATR
A10421Pictilisib (GDC-0941)
****
**
****
**
*
mTOR
A10547LY294002
*
*
*
A10172Idelalisib (CAL-101, GS-1101)
*
*
****
**
*
DNA-PK
A11016Buparlisib (BKM120, NVP-BKM120)
**
*
**
*
*
mTOR
A10726PI-103
****
****
****
***
DNA-PK,mTOR
A10923TGX-221
*
****
**
A10463IC-87114
*
**
*
A11161Wortmannin
****
DNA-PK,ATM,MLCK
A10995XL147 analogue
***
**
***
***
A11014ZSTK474
***
***
***
****
**
A11328Alpelisib (BYL719)
****
A10088AS-605240
**
*
*
***
A10729PIK-75 HCl
***
*
**
DNA-PK
A111513-Methyladenine (3-MA)
*
*
A11202A66
***
*
*
PI4Kβ
A10731PIK-93
***
*
**
***
*
**
*
PI4KIIIβ,DNA-PK,ATM
A11035Omipalisib (GSK2126458, GSK458)
****
****
****
****
mTORC1,mTORC2
A10730PIK-90
***
*
**
***
A11024PF-04691502
****
****
****
****
P-Akt (S473),P-Akt (T308),mTOR
A10112AZD6482
*
***
**
*
DNA-PK
A11023Apitolisib (GDC-0980, RG7422)
****
***
***
***
mTOR
A10438GSK1059615
****
****
****
****
mTOR
A12422Duvelisib (IPI-145, INK1197)
***
****
****
****
A11079Gedatolisib (PF-05212384, PKI-587)
****
****
mTOR
A10922TG100-115
*
*
**
**
A11099AS-252424
*
***
Casein Kinase 2
A11162BGT226 (NVP-BGT226)
****
**
***
mTOR
A11153CUDC-907
***
**
***
*
HDAC1,HDAC3,HDAC10
A10728PIK-294
*
***
**
A11197AS-604850
*
**
A11766Copanlisib (BAY 80-6946)
****
****
****
***
A11064YM201636
*
PIKfyve
A11169CH5132799
***
**
*
***
A10727PIK-293
*
*
**
*
A11089PKI-402
****
***
***
***
mTOR
A11956TG100713
**
**
***
**
A12480VS-5584 (SB2343)
****
***
****
****
mTOR
A12831Taselisib (GDC 0032)
****
***
****
****
*
*
A11363CZC24832
*
*
***
A16332IPI-549
*
*
*
***
A16277TGR-1202
***
A16272GDC-0084
****
**
****
***
mTOR
A16352AZD8835
***
*
****
**
A15868PIK-III
*
*
*
***
A15874VPS34-IN1
***
A16276Voxtalisib (XL765, SAR245409)
***
**
**
***
DNA-PK,mTOR
A15901AMG319
*
*
***
*
A15759AZD8186
***
****
***
*
A12889PF-4989216
****
**
****
**
A15283Pilaralisib (XL147)
**
***
***
***
A14338PI-3065
*
*
***
*
A13021HS-173
****
A10766Quercetin
*
*
*
PKC,Src,Sirtuin
A11784GSK2636771
A11196CAY10505
A16126LY3023414
DNA-PK,mTOR kinase
A13992GNE-317
A14441Acalisib (GS-9820)
A16273NVP-QAV-572
A16266ON 146040
***
***
A15992PQR309
A15529MLN1117 (Serabelisib)
***
A15030CAL-130
A14379Panulisib (P7170, AK151761)
ALK1, mTOR, DNA-PK
A13879 CNX-1351
****
A11198D-106669
****
A11261PX-866 (Sonolisib)
****
*
****
***
A11511NVP-BAG956
***
*
***
**
PDK1
A12935PF-04979064
****
****
****
****
mTOR
A13328ETP-46464
*
mTOR, DNA-PK, ATR, ATM
A14432GNE-493
****
***
***
***
mTOR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Items 1 to 50 of 98 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
  1. TGR-1202 hydrochloride

    Catalog No. A16278
    Quick View
    PI3Kδ inhibitor
    TGR-1202 hydrochloride is an orally available, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. Learn More
  2. GNE-317

    Catalog No. A13992
    Quick View
    PI3K inhibitor
    GNE-317 is a potent PI3K inhibitor that can cross the Blood brain barrier; shows potent suppression of the PI3K pathway in the brain of mice with intact BBB. Learn More
  3. LY3023414

    Catalog No. A16126
    Quick View
    PI3K/mTOR Dual Inhibitor
    LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). Learn More
  4. ON 146040

    Catalog No. A16266
    Quick View
    dual PI3K and BCR-ABL inhibitor
    ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K α/δ isoforms with IC50 of 14/20 nM. Learn More
  5. PI4KIIIbeta-IN-10

    Catalog No. A16269
    Quick View
    PI4KIIIβ inhibitor
    PI4KIIIbeta-IN-10 is the most potent PI4KIIIbeta inhibitor currently reported, with very minor off-target inhibition of PI4KIIIbeta related lipid kinases (IC50 = 3.6 nM). Learn More
  6. PI4KIIIbeta-IN-9

    Catalog No. A16270
    Quick View
    PI4KIIIβ inhibitor
    PI4KIIIbeta-IN-9 is a potent PI4KIIIbeta inhibitor (IC50 of 7 nM) and is >140-fold selective over PI3Kgamma and >20-fold selective over PI3Kδ, and shows no inhibition of vps34 at concentrations up to 20 uM. Learn More
  7. ETP-46321

    Catalog No. A16271
    Quick View
    PI3K α/δ inhibitor
    ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. Learn More
  8. GDC-0084

    Catalog No. A16272
    Quick View
    PI3K inhibitor
    GDC-0084 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
  9. NVP-QAV-572

    Catalog No. A16273
    Quick View
    PI3K inhibitor
    NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM. Learn More
  10. PI3K-alpha inhibitor 1

    Catalog No. A16274
    Quick View
    PI3Kα inhibitor
    PI3Kα inhibitor 1 is a PI3Kα inhibitor extracted from patent US/20120088764A1, compound 243, has an IC50 < 0.1 uM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 uM ≤ IC50 ≤ 1 uM) . Learn More
  11. PI3K-gamma inhibitor 1

    Catalog No. A16275
    Quick View
    PI3Kγ inhibitor
    PI3Kγ inhibitor 1 is a potent PI3Kγ inhibitor. Learn More
  12. SAR245409 (XL765, Voxtalisib)

    Catalog No. A16276
    Quick View
    PI3K/mTOR dual inhibitor
    SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Learn More
  13. TGR-1202

    Catalog No. A16277
    Quick View
    PI3Kδ inhibitor
    TGR-1202 is an orally available, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. Learn More
  14. PQR309

    Catalog No. A15992
    Quick View
    PI3K inhibitor
    PQR309 is an orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. Learn More
  15. PF-4989216

    Catalog No. A12889
    Quick View
    PI3K inhibitor
    PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110??, p110??, p110??, p110??, and VPS34, respectively. Learn More
  16. VS-5584

    Catalog No. A12480
    Quick View
    PI3K/mTOR inhibitor
    VS-5584 is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Learn More
  17. HS-173

    Catalog No. A13021
    Quick View
    PI3K Inhibitor
    HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. Learn More
  18. Panulisib (P7170, AK151761)

    Catalog No. A14379
    Quick View
    PI3K inhibitor
    Panulisib is a potent and selective imidazoquinoline based PI3K inhibitor with potential anticancer activity. Learn More
  19. AZD8186

    Catalog No. A14164
    Quick View
    PI3K inhibitor
    AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Learn More
  20. CAL-130

    Catalog No. A15030
    Quick View
    PI3K inhibitor
    CAL-130 is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kδ/γ as therapy for T cell acute lymphoblastic leukemia (T-ALL). Learn More
  21. CAL-130 Hydrochloride

    Catalog No. A15031
    Quick View
    PI3K inhibitor
    CAL-130 Hydrochloride is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kδ/γ as therapy for T cell acute lymphoblastic leukemia (T-ALL). Learn More
  22. LY 303511

    Catalog No. A15147
    Quick View
    PI3K inhibitor
    LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K. Learn More
  23. NVP-BKM120 Hydrochloride

    Catalog No. A15195
    Quick View
    PI3K Inhibitor‎
    NVP-BKM120 Hydrochloride is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNA-PK, with little activity to PI4Kβ. Learn More
  24. PI-103 Hydrochloride

    Catalog No. A15212
    Quick View
    PI3K Inhibitor
    PI103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. Learn More
  25. XL-147 (Pilaralisib)

    Catalog No. A15283
    Quick View
    PI3K Inhibitor
    XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases. Learn More
  26. AZD8186

    Catalog No. A15759
    Quick View
    PI3K inhibitor
    AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM). Learn More
  27. Acalisib (GS-9820)

    Catalog No. A14441
    Quick View
    PI3Kδ Inhibitor
    Acalisib is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. Learn More
  28. AMG319

    Catalog No. A15901
    Quick View
    PI3Kδ inhibitor
    AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. Learn More
  29. TG 100713

    Catalog No. A11956
    Quick View
    PI3K inhibitor
    TG 100713 is an inhibitor of PI3-kinase that inhibits endothelial cell proliferation. Learn More
  30. CZC24832

    Catalog No. A11363
    Quick View
    PI3K inhibitor
    CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Learn More
  31. IPI-145 (Duvelisib, INK1197)

    Catalog No. A12422
    Quick View
    PI3K-δ/PI3K-γ inhibitor
    IPI-145, also known as INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Learn More
  32. SF1126

    Catalog No. A12704
    Pan PI3K inhibitor
    SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. Learn More
  33. GDC-0032 (Taselisib)

    Catalog No. A12831
    Quick View
    PI3K inhibitor
    GDC-0032 is a potent, next-generation PI3 inhibitor targeting PI3 alpha. Learn More
  34. ETP-46464

    Catalog No. A13328
    Quick View
    ATR inhibitor
    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More
  35. PF-04979064

    Catalog No. A12935
    Quick View
    PI3K/mTOR Dual Inhibitor
    PF-04979064 is a highly potent and orally bioavailable PI3K/mTOR dual inhibitor. Learn More
  36. NVP-BAG956

    Catalog No. A11511
    Quick View
    PI3K/PDK-1 Inhibitor
    NVP-BAG956 acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor, displaying much reduced potency against VEGFR1 (IC50 = 2.56 uM) and little or no activity toward a panel of 15 other kinases (IC50 >10 uM). Learn More
  37. GSK2636771

    Catalog No. A11784
    Quick View
    PI3K Inhibitor
    GSK2636771 is a potent, orally bioavailable, PI3K beta-selective inhibitor. Learn More
  38. BAY 80-6946 (Copanlisib)

    Catalog No. A11766
    Quick View
    PI3K inhibitor
    BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
  39. BYL719 (Alpelisib)

    Catalog No. A11328
    Quick View
    PI3K Inhibitor
    BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Learn More
  40. PX-866 (Sonolisib)

    Catalog No. A11261
    Quick View
    PI3K inhibitor
    PX-866 is a small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. Learn More
  41. PIK-90

    Catalog No. A10730
    Quick View
    PI3K Inhibitor
    PIK-90 is a synthetic phosphoinositide 3-kinase (PI3K) inhibitor with IC50 values (nM) of 11, 350, 18, and 58 for p110 α, β, γ and δ isoforms, low mTOR activity. Learn More
  42. PIK-75

    Catalog No. A10729
    Quick View
    PI3K Inhibitor
    PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively. Learn More
  43. A66

    Catalog No. A11202
    Quick View
    PI3K inhibitor
    The S-enantiomer of A66 is a potent inhibitor of the p110alpha isoform of PI 3-kinase (PIK3CA). Learn More
  44. D-106669

    Catalog No. A11198
    Quick View
    PI3K Inhibitor

    D-106669 is a highly potent and selective PI3K inhibitor, (PI3Kα IC50 <10 nM, >3 log selectivity against tyrosine or serine/threonine kinases, except ERK1 and 2).

    Learn More
  45. CNX-1351

    Catalog No. A13879
    Quick View
    PI3Kα inhibitor
  46. GNE 477

    Catalog No. A14114
    Quick View
    PI3K/mTOR inhibitor
    GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. Learn More
  47. PI3k-delta inhibitor 1

    Catalog No. A14109
    Quick View
    PI3Kδ inhibitor
  48. SAR260301

    Catalog No. A16877
    Quick View
    PI3Kβ inhibitor
    SAR260301 is potent and selective Class I phosphatidylinositol-3-kinase (PI3K)β specific inhibitor with an IC50 of 52 nM for this isoform. Learn More
  49. Vps34-IN-2

    Catalog No. A16933
    Quick View
    Vps34 inhibitor
    Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively. Learn More
  50. leniolisib (CDZ 173)

    Catalog No. A16796
    Quick View
    PI3K inhibitor
    Leniolisib(CDZ 173) is a potent PI3Kδ selective inhibitor with biochemical IC50 values of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Learn More

Items 1 to 50 of 98 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
Rewards