VEGFR

Catalog No.Inhibitor Name VEGFR1VEGFR2VEGFR3Other
A10001Sorafenib Tosylate
**
Raf-1,B-Raf,B-Raf (V599E)
A10880Sunitinib Malate
*
Kit,FLT3,PDGFRβ
A10996Cabozantinib
***
****
***
c-Met,Kit,Axl
A10080Ponatinib
****
Abl,PDGFRα,FGFR1
A10103Axitinib
****
****
****
PDGFRβ,Kit,PDGFRα
A10998Foretinib
***
****
****
Met,Tie-2,RON
A10963Vandetanib
**
*
A10137Nintedanib
**
***
***
LCK,FLT3,FGFR2
A10250Regorafenib
***
****
*
RET,Raf-1,Kit
A11518Pazopanib HCl
***
**
*
FGFR,PDGFR,c-Kit
A10185Cediranib
***
****
****
c-Kit,PDGFRβ,FGFR1
A10703PD173074
*
FGFR1,c-Src
A11411Dovitinib
***
***
***
FLT3,c-Kit,FGFR1
A10025Linifanib
****
****
*
CSF-1R,FLT3,Kit
A10967Vatalanib 2HCl
*
**
*
PDGFRβ,c-Kit,c-Fms
A10773RAF265
**
B-Raf
A10101Tivozanib
**
***
**
EphB2,PDGFRα,PDGFRβ
A10608Motesanib Diphosphate
****
****
***
Kit,RET,PDGFR
A10340Lenvatinib
**
****
***
PDGFRβ,FGFR1,PDGFRα
A10953Orantinib
*
PDGFRβ,FGFR1
A10254Brivanib
*
**
FGFR1
A10587MGCD-265
****
****
****
Met,RON,Tie-2
A10043AEE788
*
*
*
EGFR,HER2/ErbB2,c-Abl
A10352ENMD-2076
*
**
FLT3,RET,Aurora A
A10679OSI-930
***
***
CSF-1R,LCK,C-Raf
A10248CYC116
**
Aurora A,Aurora B,FLT3
A10502Ki8751
****
c-Kit,PDGFRα,FGFR2
A10903Telatinib
***
****
c-Kit,PDGFRα
A11518Pazopanib
***
**
*
FGFR,PDGFR,c-Kit
A10504KRN 633
*
*
*
PDGFRα,c-Kit,BTK
A13377SAR131675
**
A10198Dovitinib Dilactic Acid
***
***
***
FLT3,c-Kit,FGFR1
A11407Apatinib
****
RET,c-Kit,c-Src
A10154BMS-794833
**
Met
A10162Brivanib Alaninate
*
**
FGFR1
A11396Golvatinib
**
c-Met
A11954ZM 323881 HCl
****
A11955ZM 306416
*
Src,Abl
A16342BFH772
****
A11558SU5402
**
FGFR1,PDGFRβ
A12437Semaxanib
*
A11244LY2874455
***
FGFR2,FGFR1,FGFR4
A13234SKLB1002
**
A14156AZD2932
***
PDGFRβ,Flt3,c-Kit
A10893Taxifolin (Dihydroquercetin)
A11772CP-547632
***
FGFR
A12693BAW2881 (NVP-BAW2881)
*
***
*
C-Raf-1,B-RAFV599E,c-Abl
A13465SKLB610
*
PDGFR, FGFR2
A13819TG 100801
****
***
FGFR1, Fyn, Src
A13820TG 100572
****
***
FGFR1, Fyn, Src
A14387ltiratinib (DCC2701)
***
MET, TIE2, TRK
A15073E-3810
***
**
***
FGFR-1, FGFR-2
A15287ZM323881
****
A15792BMS-817378
***
c-Met

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. E-3810

    Catalog No. A15073
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    VEGFR/FGFR Inhibitor
    E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. Learn More
  2. Vatalanib free base

    Catalog No. A21871
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    VEGFR2/KDR inhibitor
    Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM. Learn More
  3. TAS-115

    Catalog No. A21533
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    VEGFR/c-Met/HGFR inhibitor
    TAS-115 is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively. Learn More
  4. AG-13958

    Catalog No. A21175
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    VEGFR inhibitor
    AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD). Learn More
  5. ZK-261991

    Catalog No. A21140
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    VEGFR inhibitor
    ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2. Learn More
  6. VEGFR-2-IN-5

    Catalog No. A20896
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    VEGFR2 inhibitor
    VEGFR-2-IN-5 is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 31. Learn More
  7. Regorafenib Hydrochloride

    Catalog No. A11546
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    VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
    Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. Learn More
  8. SU10944

    Catalog No. A15760
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    VEGFR Inhibitor
    SU10944 is a small molecule kinase inhibitor of VEGFR that inhibits neovascularization and permeability, and is distributed to the eye upon systemic delivery. Learn More
  9. ZM323881

    Catalog No. A15287
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    VEGFR Inhibitor
    ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) with IC50 value of 2 nM. Learn More
  10. N-Desethyl Sunitinib

    Catalog No. A15182
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    VEGFR/PDGFRβ/KIT inhibitor
    N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Learn More
  11. SU14813 double bond Z

    Catalog No. A15250
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    VEGFR Inhibitor
    SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). Learn More
  12. TG 100572 HCl

    Catalog No. A15260
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    VEGFR2/Src kinase inhibitor
    TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More
  13. TG 100801 HCl

    Catalog No. A15261
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    VEGFr2 inhibitor
    TG 100801 is the prodrug of TG 100572 (HY-10184), TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More
  14. Vandetanib HCl

    Catalog No. A15271
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    VEGFR inhibitor
    Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Learn More
  15. SKLB1002

    Catalog No. A13234
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    VEGFR inhibitor
    SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Learn More
  16. TG 100572

    Catalog No. A13820
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    VEGFR2/Src inhibitor
    TG 100572 is VEGFR2 and Src kinase inhibitor. Learn More
  17. TG 100801

    Catalog No. A13819
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    VEGFR2/Src inhibitor
    TG 100801 is a VEGFR2 targeting prodrug currently in a clinical trial. The active form is TG100572. Learn More
  18. Ki 20227

    Catalog No. A11472
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    M-CSFR, CSF1R inhibitor
    Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More
  19. SAR131675

    Catalog No. A13377
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    VEGFR3 Inhibitor
    SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Learn More
  20. SKLB610

    Catalog No. A13465
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    VEGFR inhibitor
    SKLB610 is a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. Learn More
  21. AZD 2932

    Catalog No. A14156
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    mutil-targeted protein tyrosine kinase inhibitor
    AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. Learn More
  22. Fruquintinib

    Catalog No. A14393
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    VEGFR inhibitor
    Fruquintinib is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Learn More
  23. R1530

    Catalog No. A13111
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    Chk2, KDR, FGFR, Aurora A & Cdk2 inhibitor
    R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. Learn More
  24. Toceranib (PHA 291639, SU 11654)

    Catalog No. A11581
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    c-Kit, PDGFR, VEGFR inhibitor
    Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Learn More
  25. (-)-Catechin gallate

    Catalog No. A12027
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  26. LY 2874455

    Catalog No. A11244
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    FGFR/VEGFR2 inhibitor
    LY2874455 is a novel and potent FGFR/VEGFR Inhibitor. Learn More
  27. E-7050 (Golvatinib)

    Catalog No. A11396
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    E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. Learn More
  28. SU 5416 (Semaxinib)

    Catalog No. A12437
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    VEGFR Inhibitor
    SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Learn More
  29. CP-547632

    Catalog No. A11772
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    VEGFR2 inhibitor
    CP-547632 is a novel, potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor Learn More
  30. Motesanib (AMG706)

    Catalog No. A11496
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    VEGFR Inhibitor
    Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit). Learn More
  31. SU14813

    Catalog No. A11557
    VEGFR Inhibitor
    SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like tyrosine kinase 3 (FLT-3) Learn More
  32. SU-5402

    Catalog No. A11558
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    VEGFR/FGFR/EGFR inhibitor‎
    SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Learn More
  33. JI-101

    Catalog No. A13545
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    VEGFR2/PDGFRβ/EphB4 inhibitor
    JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRβ), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Learn More
  34. TAK-593

    Catalog No. A13555
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    VEGFR/PDGFR inhibitor
    TAK-593 is an oral formulation containing a small-molecule receptor tyrosine kinase inhibitor of both vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with potential antineoplastic activity. Learn More
  35. Regorafenib monohydrate

    Catalog No. A15218
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    Tyrosine kinase inhibitor
    Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Learn More
  36. SU1498

    Catalog No. A12472
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    VEGFR2 inhibitor
    SU1498 is a selective inhibitor of the VEGFR2; inhibits Flk-1 with an IC50 of value of 700 nM. Learn More
  37. ODM-203

    Catalog No. A19098
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    FGFR/VEGFR inhibitor
    ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. Learn More
  38. R916562

    Catalog No. A19374
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    Axl/VEGFR2 inhibitor
    R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis. Learn More
  39. Acrizanib

    Catalog No. A19384
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    VEGFR-2 inhibitor
    Acrizanib is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-KDR. Learn More
  40. Vorolanib

    Catalog No. A19394
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    VEGFR/PDGFR inhibitor
    Vorolanib (CM082; X-82) is an orally active, multikinase VEGFR/PDGFR inhibitor. Learn More
    • New

    SU 5205

    Catalog No. A17153
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    VEGFR2 inhibitor
    SU 5205 is a VEGFR2 inhibitor. Learn More
    • New

    SU-5408

    Catalog No. A17154
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    VEGFR2 Kinase Inhibitor
    SU-5408, also known as VEGFR2 Kinase Inhibitor I, is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase with IC50 value of 70 nM. Learn More
  41. Ningetinib Tosylate

    Catalog No. A17039
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    VEGF and PDGF inhibitor
    Ningetinib Tosylate,also known as CT-053Tosylate and DE-120, is a VEGF and PDGF inhibitor potentially for the treatment of wet age-related macular degeneration. CAS: 1394820-69-9 (free base) 1394820-77-9 (tosylate) Learn More
  42. BFH772

    Catalog No. A16342
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    VEGFR2 inhibitor
    BFH772 is a potent oral VEGFR2 inhibitor, which is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. Learn More
  43. EG00229

    Catalog No. A16237
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    neuropilin-1/VEGF-A inhibitor
    EG00229 is the first small molecule inhibitors of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 uM(125I-VEGF binding to PAE/NRP1 cells). Learn More
  44. Nintedanib esylate

    Catalog No. A16197
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    RTK inhibitor
    Nintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Learn More
  45. NVP-BAW2881

    Catalog No. A12693
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    VEGFR inhibitor
    NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. Learn More
  46. NVP-ACC789

    Catalog No. A13240
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    VEGFR-2 inhibitor
    NVP-ACC789 is an inhibitor of VEGFR-2 (FLK-1/KDR). Learn More
  47. Altiratinib (DCC2701)

    Catalog No. A14387
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    c-Met/VEGFR inhibitor
    Altiratinib is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Learn More
  48. BMS-817378

    Catalog No. A15792
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    MET/VEGFR-2 inhibitor
    BMS-817378 is a novel prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833. Learn More

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