VEGFR

Catalog No.Inhibitor Name VEGFR1VEGFR2VEGFR3Other
A10001Sorafenib Tosylate
**
Raf-1,B-Raf,B-Raf (V599E)
A10880Sunitinib Malate
*
Kit,FLT3,PDGFRβ
A10996Cabozantinib
***
****
***
c-Met,Kit,Axl
A10080Ponatinib
****
Abl,PDGFRα,FGFR1
A10103Axitinib
****
****
****
PDGFRβ,Kit,PDGFRα
A10998Foretinib
***
****
****
Met,Tie-2,RON
A10963Vandetanib
**
*
A10137Nintedanib
**
***
***
LCK,FLT3,FGFR2
A10250Regorafenib
***
****
*
RET,Raf-1,Kit
A11518Pazopanib HCl
***
**
*
FGFR,PDGFR,c-Kit
A10185Cediranib
***
****
****
c-Kit,PDGFRβ,FGFR1
A10703PD173074
*
FGFR1,c-Src
A11411Dovitinib
***
***
***
FLT3,c-Kit,FGFR1
A10025Linifanib
****
****
*
CSF-1R,FLT3,Kit
A10967Vatalanib 2HCl
*
**
*
PDGFRβ,c-Kit,c-Fms
A10773RAF265
**
B-Raf
A10101Tivozanib
**
***
**
EphB2,PDGFRα,PDGFRβ
A10608Motesanib Diphosphate
****
****
***
Kit,RET,PDGFR
A10340Lenvatinib
**
****
***
PDGFRβ,FGFR1,PDGFRα
A10953Orantinib
*
PDGFRβ,FGFR1
A10254Brivanib
*
**
FGFR1
A10587MGCD-265
****
****
****
Met,RON,Tie-2
A10043AEE788
*
*
*
EGFR,HER2/ErbB2,c-Abl
A10352ENMD-2076
*
**
FLT3,RET,Aurora A
A10679OSI-930
***
***
CSF-1R,LCK,C-Raf
A10248CYC116
**
Aurora A,Aurora B,FLT3
A10502Ki8751
****
c-Kit,PDGFRα,FGFR2
A10903Telatinib
***
****
c-Kit,PDGFRα
A11518Pazopanib
***
**
*
FGFR,PDGFR,c-Kit
A10504KRN 633
*
*
*
PDGFRα,c-Kit,BTK
A13377SAR131675
**
A10198Dovitinib Dilactic Acid
***
***
***
FLT3,c-Kit,FGFR1
A11407Apatinib
****
RET,c-Kit,c-Src
A10154BMS-794833
**
Met
A10162Brivanib Alaninate
*
**
FGFR1
A11396Golvatinib
**
c-Met
A11954ZM 323881 HCl
****
A11955ZM 306416
*
Src,Abl
A16342BFH772
****
A11558SU5402
**
FGFR1,PDGFRβ
A12437Semaxanib
*
A11244LY2874455
***
FGFR2,FGFR1,FGFR4
A13234SKLB1002
**
A14156AZD2932
***
PDGFRβ,Flt3,c-Kit
A10893Taxifolin (Dihydroquercetin)
A11772CP-547632
***
FGFR
A12693BAW2881 (NVP-BAW2881)
*
***
*
C-Raf-1,B-RAFV599E,c-Abl
A13465SKLB610
*
PDGFR, FGFR2
A13819TG 100801
****
***
FGFR1, Fyn, Src
A13820TG 100572
****
***
FGFR1, Fyn, Src
A14387ltiratinib (DCC2701)
***
MET, TIE2, TRK
A15073E-3810
***
**
***
FGFR-1, FGFR-2
A15287ZM323881
****
A15792BMS-817378
***
c-Met

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Regorafenib (BAY 73-4506)

    Catalog No. A10250
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    VEGFR inhibitor
    Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More
  2. Vandetanib (ZD6474)

    Catalog No. A10963
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    VEGFR inhibitor
    Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. Learn More
  3. Sorafenib Tosylate (Nexavar)

    Catalog No. A10001
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    Raf inhibitor
    Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Learn More
  4. Axitinib

    Catalog No. A10103
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    VEGFR inhibitor
    Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). Learn More
  5. XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR inhibitor
    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More
  6. Dovitinib (TKI-258)

    Catalog No. A11411
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    RTK inhibitor
    Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More
  7. Foretinib (GSK1363089, XL880)

    Catalog No. A10998
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    c-MET inhibitor
    Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis. Learn More
  8. Cediranib (AZD2171)

    Catalog No. A10185
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    VEGFR inhibitor
    Cediranib (AZD2171) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. Learn More
  9. Tivozanib (AV-951)

    Catalog No. A10101
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    VEGFR Inhibitor
    Tivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors. Learn More
  10. Bibf1120 (Nintedanib)

    Catalog No. A10137
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    VEGFR inhibitor
    BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR. Learn More
  11. PD173074

    Catalog No. A10703
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    FGFR1/VEGFR2 Inhibitor
    PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR. Learn More
  12. Brivanib (BMS-540215)

    Catalog No. A10254
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    VEGFR-2 inhibitor
    Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM. Learn More
  13. Linifanib (ABT-869)

    Catalog No. A10025
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    VEGFR/PDGFR inhibitor
    Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. Learn More
  14. Taxifolin

    Catalog No. A10893
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    VEGFR-2 Inhibitor
    Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibitor. Learn More
  15. Apatinib (YN968D1)

    Catalog No. A11407
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    VEGFR inhibitor
    Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Learn More
  16. Pazopanib HCl (GW786034)

    Catalog No. A10699
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    VEGFR/PDGFR/FGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  17. Sunitinib Malate

    Catalog No. A10880
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    RTK inhibitor
    Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Learn More
  18. E7080 (Lenvatinib)

    Catalog No. A10340
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    VEGFR Inhibitor
    E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases. Learn More
  19. Ki8751

    Catalog No. A10502
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    VEGFR-2 inhibitor
    Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays. Learn More
  20. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  21. (-)-Catechin gallate

    Catalog No. A12027
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  22. SU 5416 (Semaxinib)

    Catalog No. A12437
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    VEGFR Inhibitor
    SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Learn More
  23. Motesanib (AMG706)

    Catalog No. A11496
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    VEGFR Inhibitor
    Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit). Learn More
  24. SU-5402

    Catalog No. A11558
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    VEGFR/FGFR/EGFR inhibitor‎
    SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Learn More
  25. Toceranib (PHA 291639, SU 11654)

    Catalog No. A11581
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    c-Kit, PDGFR, VEGFR inhibitor
    Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Learn More
  26. Ki 20227

    Catalog No. A11472
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    M-CSFR, CSF1R inhibitor
    Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More
  27. E-3810

    Catalog No. A15073
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    VEGFR/FGFR Inhibitor
    E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. Learn More
  28. N-Desethyl Sunitinib

    Catalog No. A15182
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    VEGFR/PDGFRβ/KIT inhibitor
    N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Learn More
  29. SU14813 double bond Z

    Catalog No. A15250
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    VEGFR Inhibitor
    SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). Learn More
  30. TG 100572 HCl

    Catalog No. A15260
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    VEGFR2/Src kinase inhibitor
    TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More
  31. TG 100801 HCl

    Catalog No. A15261
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    VEGFr2 inhibitor
    TG 100801 is the prodrug of TG 100572 (HY-10184), TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More
  32. Vandetanib HCl

    Catalog No. A15271
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    VEGFR inhibitor
    Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Learn More
  33. ZM323881

    Catalog No. A15287
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    VEGFR Inhibitor
    ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) with IC50 value of 2 nM. Learn More
  34. SU10944

    Catalog No. A15760
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    VEGFR Inhibitor
    SU10944 is a small molecule kinase inhibitor of VEGFR that inhibits neovascularization and permeability, and is distributed to the eye upon systemic delivery. Learn More
  35. Nintedanib esylate

    Catalog No. A16197
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    RTK inhibitor
    Nintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Learn More
  36. Regorafenib Hydrochloride

    Catalog No. A11546
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    VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
    Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. Learn More
  37. VEGFR-2-IN-5

    Catalog No. A20896
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    VEGFR2 inhibitor
    VEGFR-2-IN-5 is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 31. Learn More
  38. ZK-261991

    Catalog No. A21140
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    VEGFR inhibitor
    ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2. Learn More
  39. AG-13958

    Catalog No. A21175
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    VEGFR inhibitor
    AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD). Learn More
  40. TAS-115

    Catalog No. A21533
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    VEGFR/c-Met/HGFR inhibitor
    TAS-115 is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively. Learn More
  41. Vatalanib free base

    Catalog No. A21871
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    VEGFR2/KDR inhibitor
    Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM. Learn More
  42. KDR-in-4

    Catalog No. A20219
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    KDR/VEGFR2 inhibitor
    KDR-in-4 is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM. Learn More
  43. CP-547632 hydrochloride

    Catalog No. A22019
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    VEGFR-2/FGFR inhibitor
    CP-547632 hydrochloride is a well-tolerated, orally-bioavailable inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases with IC50s of 11 nM and 9 nM, respectively. Learn More
  44. SU4312

    Catalog No. A22671
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    VEGFR and PDGFR tyrosine kinases inhibitor
    SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Learn More
  45. ZM323881 hydrochloride

    Catalog No. A22392
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    VEGFR2 inhibitor
    ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. Learn More
  46. ZD-4190

    Catalog No. A22369
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    VEGFR2 and EGFR signalling inhibitor
    ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer. Learn More
  47. JNJ-38158471

    Catalog No. A22345
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    VEGFR-2 inhibitor
    JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively. Learn More
  48. MAZ51

    Catalog No. A22331
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    VEGFR-3 (Flt-4) tyrosine kinase inhibitor
    MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. Learn More
  49. RAF265 (CHIR-265)

    Catalog No. A10773
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    RAF/VEGFR Inhibitor
    RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers. Learn More
  50. AEE788

    Catalog No. A10043
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    EGFR inhibitor
    AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2. Learn More

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