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| Catalog No. | Inhibitor Name | VEGFR1 | VEGFR2 | VEGFR3 | Other |
|---|---|---|---|---|---|
| A10001 | Sorafenib Tosylate | ** | Raf-1,B-Raf,B-Raf (V599E) | ||
| A10880 | Sunitinib Malate | * | Kit,FLT3,PDGFRβ | ||
| A10996 | Cabozantinib | *** | **** | *** | c-Met,Kit,Axl |
| A10080 | Ponatinib | **** | Abl,PDGFRα,FGFR1 | ||
| A10103 | Axitinib | **** | **** | **** | PDGFRβ,Kit,PDGFRα |
| A10998 | Foretinib | *** | **** | **** | Met,Tie-2,RON |
| A10963 | Vandetanib | ** | * | ||
| A10137 | Nintedanib | ** | *** | *** | LCK,FLT3,FGFR2 |
| A10250 | Regorafenib | *** | **** | * | RET,Raf-1,Kit |
| A11518 | Pazopanib HCl | *** | ** | * | FGFR,PDGFR,c-Kit |
| A10185 | Cediranib | *** | **** | **** | c-Kit,PDGFRβ,FGFR1 |
| A10703 | PD173074 | * | FGFR1,c-Src | ||
| A11411 | Dovitinib | *** | *** | *** | FLT3,c-Kit,FGFR1 |
| A10025 | Linifanib | **** | **** | * | CSF-1R,FLT3,Kit |
| A10967 | Vatalanib 2HCl | * | ** | * | PDGFRβ,c-Kit,c-Fms |
| A10773 | RAF265 | ** | B-Raf | ||
| A10101 | Tivozanib | ** | *** | ** | EphB2,PDGFRα,PDGFRβ |
| A10608 | Motesanib Diphosphate | **** | **** | *** | Kit,RET,PDGFR |
| A10340 | Lenvatinib | ** | **** | *** | PDGFRβ,FGFR1,PDGFRα |
| A10953 | Orantinib | * | PDGFRβ,FGFR1 | ||
| A10254 | Brivanib | * | ** | FGFR1 | |
| A10587 | MGCD-265 | **** | **** | **** | Met,RON,Tie-2 |
| A10043 | AEE788 | * | * | * | EGFR,HER2/ErbB2,c-Abl |
| A10352 | ENMD-2076 | * | ** | FLT3,RET,Aurora A | |
| A10679 | OSI-930 | *** | *** | CSF-1R,LCK,C-Raf | |
| A10248 | CYC116 | ** | Aurora A,Aurora B,FLT3 | ||
| A10502 | Ki8751 | **** | c-Kit,PDGFRα,FGFR2 | ||
| A10903 | Telatinib | *** | **** | c-Kit,PDGFRα | |
| A11518 | Pazopanib | *** | ** | * | FGFR,PDGFR,c-Kit |
| A10504 | KRN 633 | * | * | * | PDGFRα,c-Kit,BTK |
| A13377 | SAR131675 | ** | |||
| A10198 | Dovitinib Dilactic Acid | *** | *** | *** | FLT3,c-Kit,FGFR1 |
| A11407 | Apatinib | **** | RET,c-Kit,c-Src | ||
| A10154 | BMS-794833 | ** | Met | ||
| A10162 | Brivanib Alaninate | * | ** | FGFR1 | |
| A11396 | Golvatinib | ** | c-Met | ||
| A11954 | ZM 323881 HCl | **** | |||
| A11955 | ZM 306416 | * | Src,Abl | ||
| A16342 | BFH772 | **** | |||
| A11558 | SU5402 | ** | FGFR1,PDGFRβ | ||
| A12437 | Semaxanib | * | |||
| A11244 | LY2874455 | *** | FGFR2,FGFR1,FGFR4 | ||
| A13234 | SKLB1002 | ** | |||
| A14156 | AZD2932 | *** | PDGFRβ,Flt3,c-Kit | ||
| A10893 | Taxifolin (Dihydroquercetin) | ||||
| A11772 | CP-547632 | *** | FGFR | ||
| A12693 | BAW2881 (NVP-BAW2881) | * | *** | * | C-Raf-1,B-RAFV599E,c-Abl |
| A13465 | SKLB610 | * | PDGFR, FGFR2 | ||
| A13819 | TG 100801 | **** | *** | FGFR1, Fyn, Src | |
| A13820 | TG 100572 | **** | *** | FGFR1, Fyn, Src | |
| A14387 | ltiratinib (DCC2701) | *** | MET, TIE2, TRK | ||
| A15073 | E-3810 | *** | ** | *** | FGFR-1, FGFR-2 |
| A15287 | ZM323881 | **** | |||
| A15792 | BMS-817378 | *** | c-Met |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Vatalanib free base
Catalog No. A21871 VEGFR2/KDR inhibitorVatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM. Learn More -
TG 100572 HCl
Catalog No. A15260 VEGFR2/Src kinase inhibitorTG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More -
SU14813 double bond Z
Catalog No. A15250 VEGFR InhibitorSU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). Learn More -
N-Desethyl Sunitinib
Catalog No. A15182 VEGFR/PDGFRβ/KIT inhibitorN-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Learn More -
E-3810
Catalog No. A15073 VEGFR/FGFR InhibitorE-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VEGFR-1, VEGFR-2, VEGFR-3, FGFR-1 and FGFR-2, respectively. Learn More -
Ki 20227
Catalog No. A11472 M-CSFR, CSF1R inhibitorKi 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More -
Toceranib (PHA 291639, SU 11654)
Catalog No. A11581 c-Kit, PDGFR, VEGFR inhibitorToceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Learn More -
SU-5402
Catalog No. A11558 VEGFR/FGFR/EGFR inhibitorSU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Learn More -
Motesanib (AMG706)
Catalog No. A11496 VEGFR InhibitorMotesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit). Learn More -
TG 100801 HCl
Catalog No. A15261 VEGFr2 inhibitorTG 100801 is the prodrug of TG 100572 (HY-10184), TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More -
Vandetanib HCl
Catalog No. A15271 VEGFR inhibitorVandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Learn More -
TAS-115
Catalog No. A21533 VEGFR/c-Met/HGFR inhibitorTAS-115 is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively. Learn More -
AG-13958
Catalog No. A21175 VEGFR inhibitorAG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD). Learn More -
ZK-261991
Catalog No. A21140 VEGFR inhibitorZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2. Learn More -
VEGFR-2-IN-5
Catalog No. A20896 VEGFR2 inhibitorVEGFR-2-IN-5 is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 31. Learn More -
Regorafenib Hydrochloride
Catalog No. A11546 VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitorRegorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. Learn More -
Nintedanib esylate
Catalog No. A16197 RTK inhibitorNintedanib is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Learn More -
SU10944
Catalog No. A15760 VEGFR InhibitorSU10944 is a small molecule kinase inhibitor of VEGFR that inhibits neovascularization and permeability, and is distributed to the eye upon systemic delivery. Learn More -
ZM323881
Catalog No. A15287 VEGFR InhibitorZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) with IC50 value of 2 nM. Learn More -
SU 5416 (Semaxinib)
Catalog No. A12437 VEGFR InhibitorSU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Learn More -
(-)-Catechin gallate
Catalog No. A12027 (-)-Catechin gallate is an antioxidant constituent of green tea. At uM concentrations, inhibits VEGF-induced tyrosine phosphorylation. Learn More -
Pazopanib (GW-786034)
Catalog No. A11518 VEGFR inhibitorPazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More -
Cediranib (AZD2171)
Catalog No. A10185 VEGFR inhibitorCediranib (AZD2171) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. Learn More -
Foretinib (GSK1363089, XL880)
Catalog No. A10998 c-MET inhibitorForetinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis. Learn More -
Dovitinib (TKI-258)
Catalog No. A11411 RTK inhibitorDovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Learn More -
XL184 free base (Cabozantinib)
Catalog No. A10996 VEGFR inhibitorXL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Learn More -
Axitinib
Catalog No. A10103 VEGFR inhibitorAxitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117). Learn More -
Sorafenib Tosylate (Nexavar)
Catalog No. A10001 Raf inhibitorSorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Learn More -
Vandetanib (ZD6474)
Catalog No. A10963 VEGFR inhibitorVandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. Learn More -
Regorafenib (BAY 73-4506)
Catalog No. A10250 VEGFR inhibitorRegorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. Learn More -
Tivozanib (AV-951)
Catalog No. A10101 VEGFR InhibitorTivozanib (AV-951) is an oral VEGF receptor tyrosine kinase inhibitor that is designed to inhibit all three VEGF receptors. Learn More -
Bibf1120 (Nintedanib)
Catalog No. A10137 VEGFR inhibitorBIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR. Learn More -
PD173074
Catalog No. A10703 FGFR1/VEGFR2 InhibitorPD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR. Learn More -
Ki8751
Catalog No. A10502 VEGFR-2 inhibitorKi8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays. Learn More -
E7080 (Lenvatinib)
Catalog No. A10340 VEGFR InhibitorE7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases. Learn More -
Sunitinib Malate
Catalog No. A10880 RTK inhibitorSunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Learn More -
Pazopanib HCl (GW786034)
Catalog No. A10699 VEGFR/PDGFR/FGFR inhibitorPazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More -
Apatinib (YN968D1)
Catalog No. A11407 VEGFR inhibitorApatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also known as KDR) that inhibits VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Learn More -
Taxifolin
Catalog No. A10893 VEGFR-2 InhibitorTaxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibitor. Learn More -
Linifanib (ABT-869)
Catalog No. A10025 VEGFR/PDGFR inhibitorLinifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. Learn More -
Brivanib (BMS-540215)
Catalog No. A10254 VEGFR-2 inhibitorBrivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM. Learn More -
TAK-593
Catalog No. A13555 VEGFR/PDGFR inhibitorTAK-593 is an oral formulation containing a small-molecule receptor tyrosine kinase inhibitor of both vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with potential antineoplastic activity. Learn More -
Regorafenib monohydrate
Catalog No. A15218 Tyrosine kinase inhibitorRegorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively. Learn More -
Toceranib phosphate
Catalog No. A15263 Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. Learn More -
Vandetanib trifluoroacetate
Catalog No. A15272 VEGFR/EGFR inhibitorVandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Learn More -
BMS-817378
Catalog No. A15792 MET/VEGFR-2 inhibitorBMS-817378 is a novel prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833. Learn More -
JI-101
Catalog No. A13545 VEGFR2/PDGFRβ/EphB4 inhibitorJI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRβ), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Learn More -
Fruquintinib
Catalog No. A14393 VEGFR inhibitorFruquintinib is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Learn More -
AZD 2932
Catalog No. A14156 mutil-targeted protein tyrosine kinase inhibitorAZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. Learn More -
SKLB610
Catalog No. A13465 VEGFR inhibitorSKLB610 is a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. Learn More
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