• Sign In
  • FAQ
  • Create an Account
  • 866-930-6790
Currency
USD
Toggle Nav
My Cart
Search
Menu
Account
Settings
Currency
USD

MAPK

Shop By
Clear All

Items 51-100 of 600

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Product Citation
  1. A10422
    Gefitinib (Iressa)

    EGFR Inhibitor

    Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
    Quick View
  2. A10425
    Genistein

    EGFR inhibitor

    Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
    Quick View
  3. A10426
    Genistin (Genistoside)

    Genistin is an isoflavone found in a number of dietary plants like soy and kudzu. It was shown to stimulate estrogen-dependent breast cancer cell growth in vivo.
    Quick View
  4. A10440
    GSK1904529A

    IGF-1R inhibitor

    GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively.
    Quick View
  5. A10468
    Imatinib Mesylate

    Bcr-Abl inhibitor

    Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
    Quick View
  6. A10493
    JNJ-38877605

    c-Met inhibitor

    c-Met inhibitor JNJ-38877605 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways.
    Quick View
  7. A10502
    Ki8751

    VEGFR-2 inhibitor

    Ki8751 is a cell-permeable quinolyloxyphenyl-urea compound that acts as a Flk-1 (VEGFR-2)-selective inhibitior in both cell-based and cell-free assays.
    Quick View
  8. A10504
    KRN 633

    VEGFR Inhibitor

    KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ??? 10 μM).
    Quick View
  9. A10508
    KW-2449

    FLT3/FGFR/Bcr-Abl/Aurora Inhibitor

    KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
    Quick View
  10. A10514
    Lapatinib Ditosylate

    HER2 inhibitor

    Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.
    Quick View
  11. A10558
    Masitinib ( AB1010)

    c-Kit inhibitor

    Masitinib (AB1010) is a protein tyrosine kinase inhibitor.
    Quick View
  12. A10587
    MGCD-265 (Glesatinib)

    c-Met inhibitor

    MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs, including the c-Met receptor (HGFR); the Tek/Tie-2 receptor; VEGFR types 1, 2, and 3; and MST1R.
    Quick View
  13. A10608
    Motesanib Diphosphate (AMG-706)

    VEGFR inhibitor

    Motesanib, also known as AMG-706, is an orally administered multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors, and Kit receptors.
    Quick View
  14. A10610
    MP470 (MP-470, Amuvatinib)

    RTK inhibitor

    MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor.
    Quick View
  15. A10612
    Mubritinib (TAK 165)

    HER2/ErbB2 inhibitor

    Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 μM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5.
    Quick View
  16. A10638
    Neratinib (HKI-272)

    HER2 inhibitor

    Neratinib (HKI-272) is a tyrosine kinase inhibitor.
    Quick View
  17. A10658
    NVP-ADW742

    IGF-1R inhibitor

    NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
    Quick View
  18. A10662
    TAE684

    ALK Inhibitor

    TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).
    Quick View
  19. A10678
    OSI-420

    EGFR Inhibitor

    OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by inhibition of the intercellular domain .
    Quick View
  20. A10679
    OSI-930

    c-Kit/VEGFR Inhibitor

    OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.
    Quick View
  21. A10699
    Pazopanib HCl (GW786034)

    VEGFR/PDGFR/FGFR inhibitor

    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
    Quick View
  22. A10702
    PD153035 (HCl salt)

    EGFR inhibitor

    PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.
    Quick View
  23. A10703
    PD173074

    FGFR1/VEGFR2 Inhibitor

    PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
    Quick View
  24. A10706
    Pelitinib (EKB-569)

    EGFR inhibitor

    Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
    Quick View
  25. A10711
    PF-04217903

    c-Met Inhibitor

    PF-04217903 is a novel c-Met/hepatocyte growth factor receptor tyrosine kinase inhibitors.
    Quick View
  26. A10712
    PF-2341066 (Crizotinib)

    ALK/ c-Met inhibitor

    PF-2341066 (Crizotinib) is an inhibitor of the c-Met kinase and the NPM-ALK. PF-2341066 inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM).
    Quick View
  27. A10713
    PHA-665752

    c-Met Inhibitor

    PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.
    Quick View
  28. A10715
    Danusertib (PHA-739358)

    Aurora inhibitor

    Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
    Quick View
  29. A10766
    Quercetin (Sophoretin)

    MAO-B inhibitor

    Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.
    Quick View
  30. A10769
    R406 besylate

    Syk Inhibitor

    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
    Quick View
  31. A10770
    R406 (Tamatinib)

    Syk Inhibitor

    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
    Quick View
  32. A10827
    SB 525334

    ALK Inhibitor

    SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells
    Quick View
  33. A10839
    SGX-523

    c-Met Inhibitor

    SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
    Quick View
  34. A10869
    SU11274

    c-Met inhibitor

    SU11274 is a Met tyrosine kinase inhibitor.
    Quick View
  35. A10880
    Sunitinib Malate

    RTK inhibitor

    Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
    Quick View
  36. A10887
    Tandutinib (MLN518)

    FLT3 Inhibitor

    Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.
    Quick View
  37. A10893
    Taxifolin

    VEGFR-2 Inhibitor

    Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibitor.
    Quick View
  38. A10903
    Telatinib (BAY 57-9352)

    VEGFR-2 inhibitor

    Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases.
    Quick View
  39. A10932
    Tie2 kinase inhibitor

    Tie2 kinase inhibitor

    Tie2 kinase inhibitor is a potent and selective Tie2 inhibitor with IC50 of 0.25 μM.
    Quick View
  40. A10953
    TSU-68 (Orantinib, SU6668)

    PDFGRβ inhibitor

    Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.
    Quick View
  41. A10963
    Vandetanib (ZD6474)

    VEGFR inhibitor

    Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
    Quick View
  42. A10967
    Vatalanib (PTK787) 2HCl

    VEGFR inhibitor

    Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2. CAS: 212141-51-0 (HCl) 212141-54-3 (Free base)
    Quick View
  43. A10990
    WZ3146

    EGFR Inhibitor

    WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.
    Quick View
  44. A10991
    WZ4002

    EGFR Inhibitor

    WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib.
    Quick View
  45. A10992
    WZ8040

    EGFR Inhibitor

    WZ8040 is a novel EGFR inhibitors that suppress the growth of EGFR-T790M-containing cell lines and inhibit EGFR phosphorylation.
    Quick View
  46. A10996
    XL184 free base (Cabozantinib)

    VEGFR inhibitor

    XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2.
    Quick View
  47. A10998
    Foretinib (GSK1363089, XL880)

    c-MET inhibitor

    Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
    Quick View
  48. A11021
    NVP-AEW541

    IGF-1R inhibitor

    NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
    Quick View
  49. A11022
    AG-1478 (Tyrphostin AG-1478)

    EGFR Inhibitor

    AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
    Quick View
  50. A11027
    Arry-380 analog

    HER2 Inhibitor

    ARRY-380 is an ErbB-2 inhibitor that selectively binds to and inhibits the phosphorylation of ErbB-2, resulting in growth inhibition and death of ErbB-2-expressing tumor cells.
    Quick View

Items 51-100 of 600

Page
per page
Set Descending Direction
Shop By
Now Shopping by
  1. Category
    Protein Tyrosine Kinases
Clear All
Shopping Options
Category
Actions
  1. Inhibitor 544 items
  2. Agonist 3 items
  3. Antagonist 4 items
  4. Activator 3 items
  5. Modulator 2 items
  6. Blocker 1 item
  7. Degrader 3 items
  8. Stimulator 1 item
On sale
  1. Yes 1 item
Price
  1. $0.00 - $1,000.00 596 items
  2. $1,000.00 - $2,000.00 3 items
  3. $5,000.00 - $6,000.00 1 item